Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial

Early interventions are a preferred method for addressing behavioral problems in high‐risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve efficiency. One potential source of such variation is the genome. We conducted a genetic analysis of the Fast Track randomized control trial, a 10‐year‐long intervention to prevent high‐risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior. We tested whether variants of the glucocorticoid receptor gene NR3C1 were associated with differences in response to the Fast Track intervention. We found that in European‐American children, a variant of NR3C1 identified by the single‐nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in control group children and decreased risk for externalizing psychopathology in intervention group children. Variation in NR3C1 measured in this study was not associated with differential intervention response in African‐American children. We discuss implications for efforts to prevent externalizing problems in high‐risk children and for public policy in the genomic era.     

The relationship between physical and sexual abuse and drug use in a sample of juvenile detainees in Florida and a sample of committed youthful offenders in Colorado

The relationships between child physical and sexual abuse and illicit drug use are little understood and underinvestigated. Data gathered from a study of youths located in two different institutions for detained (Florida) and committed (Colorado) youthful offenders permitted an examination of this issue. The results indicate the youths' physical and sexual abuse experiences are significantly and positively related to their use of illicit drugs. The implications of these findings for further research are drawn.     

Further data on the development of red blood cell antigens Lua,Lub, and Cob

One hundred and fifty-five cord cells were tested for the red blood cell antigens Lu^a, Lu^b and Co^b in order to collect data on the early postnatal expression of these markers. Additionally, dosage studies were carried out in 8–10-month-old heterozygous children. Antigens Lu^a and Lu^b revealed to be significantly less expressed in children of both ages compared with those of their mothers, whereas no such differences could be demonstrated in the expression of the antigen Co^b.     

Die Bundesrepublik Deutschland nach der Bundestagswahl 2002 — Überlegungen eines Wahlsoziologen

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