Fatal intoxication involving 2-methyl AP-237

Novel synthetic opioids contribute considerably to the opioid epidemic, especially with the frequent emergence of structurally similar compounds. This case report describes a fatal intoxication involving 2-methyl AP-237. A 54-year-old Caucasian male was found deceased from an apparent drug overdose. A plastic container labeled “2MAP” and a cut straw were found in the decedent's backpack at the scene. A white substance found in the container tested positive for fentanyl by field testing. According to his medical history, the decedent was treated for a drug overdose 3 years prior to his death. With no diagnostic findings at autopsy, the case was submitted for toxicological analysis. An unknown substance was detected in peripheral blood and urine using gas chromatography with nitrogen phosphorous detection (GC-NPD). Further testing was conducted using gas chromatography–mass spectrometry (GC–MS) and liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-QTOF-MS) which confirmed the presence of 2-methyl AP-237 and potential metabolites in blood and urine. Quantitation by GC-NPD revealed concentrations of 2-methyl AP-237 in blood and urine at 480 ng/mL and 4200 ng/mL, respectively. The toxicological analysis also identified and quantitated alprazolam in the blood at 55 ng/mL. Additionally, the metabolism of 2-methyl AP-237 was investigated and three hydroxylated metabolites were identified in peripheral blood and urine. Limited literature is available for the detection and quantitation of 2-methyl AP-237 in postmortem specimens. Given the toxicological findings with unremarkable autopsy findings, this case is an example of a fatal intoxication involving 2-methyl AP-237.     

Competition and solidarity: union members and immigration in Europe

This article addresses an understudied question in the comparative political economy of migration. How have trade unions shaped the attitudes of their members toward immigration? Unions are at the core of left-wing politics in most European countries, and support for immigration is usually a left-wing position. However, many of the core constituents of unions are those whose interests are most likely to be adversely affected by an increase in the supply of labour. The article shows that the pattern of European trade union leaders becoming supportive of open immigration policies has solidified over the past decade. It then provides evidence that this rhetoric has shaped the attitudes of union members and that the effect has become stronger over time. Finally, it shows that the effect is robust to the exclusion of countries where self-selection into unions on the basis of ideology is likely to be strongest.     

Unresponsive and Unpersuaded: The Unintended Consequences of a Voter Persuasion Effort

To date, field experiments on campaign tactics have focused overwhelmingly on mobilization and voter turnout, with far more limited attention to persuasion and vote choice. In this paper, we analyze a field experiment with 56,000 Wisconsin voters designed to measure the persuasive effects of canvassing, phone calls, and mailings during the 2008 presidential election. Focusing on the canvassing treatment, we find that persuasive appeals had two unintended consequences. First, they reduced responsiveness to a follow-up survey among infrequent voters, a substantively meaningful behavioral response that has the potential to induce bias in estimates of persuasion effects as well. Second, the persuasive appeals possibly reduced candidate support and almost certainly did not increase it. This counterintuitive finding is reinforced by multiple statistical methods and suggests that contact by a political campaign may engender a backlash.     

Endogenous Credible Commitment and Party Competition over Redistribution under Alternative Electoral Institutions

Political parties competing in elections for the power to set public policy face the problem of making credible their policy promises to voters. I argue that this commitment problem crucially shapes party competition over redistribution. The model I develop shows that under majoritarian electoral rules, parties' efforts to achieve endogenous commitment to policies preferred by the middle class lead to different behavior and outcomes than suggested by existing theories, which either assume commitment or rule out endogenous commitment. Thus, left parties can have incentives to respond to rising income inequality by moving to the right in majoritarian systems but not under proportional representation. The model also generates new insights about the anti‐left electoral bias often attributed to majoritarian electoral rules, and the strategic use of parliamentary candidates as a commitment device. I find evidence for key implications of this logic using panel data on party positions in 16 parliamentary democracies.     

Can Social Media Predict Election Results? Evidence From New Zealand

The importance of social media for election campaigning has received a lot of attention recently. Using data from the 2011 New Zealand general election and the size of candidates’ social media networks on Facebook and Twitter, we investigate whether social media is associated with election votes and probability of election success. Overall, our results suggest that there is a statistically significant relationship between the size of online social networks and election voting and election results. However, the size of the effect is small and it appears that social media presence is therefore only predictive in closely contested elections.     

How Language Can Influence Political Marketing Strategy and a Candidate's Image: Effect of Presidential Candidates' Language Intensity and Experience on College Students' Ratings of Source Credibility

The present study examines the effects of language intensity on presidential candidates' credibility. We manipulated language intensity levels and experience levels for hypothetical candidates for president of the United States. Manipulation checks confirmed the effectiveness of the experimental conditions. The dimensions of source credibility, character, and authoritativeness were confirmed using confirmatory factor analysis. Analysis of variance indicated that candidates using low-intensity language received higher scores on character than did candidates using high-intensity language. Experienced candidates received higher scores on authoritativeness than did inexperienced candidates. Implications for political marketing of candidates are discussed.     

Three Decades of Policy Layering and Politically Sustainable Reform in the European Union's Agricultural Policy

The study of policy reform has tended to focus on single‐stage reforms taking place over a relatively short period. Recent research has drawn attention to gradual policy changes unfolding over extended periods. One strategy of gradual change is layering, in which new policy dimensions are introduced by adding new policy instruments or by redesigning existing ones to address new concerns. The limited research on single‐stage policy reforms highlights that these may not endure in the postenactment phase when circumstances change. We argue that gradual policy layering may create sustainability dynamics that can result in lasting reform trajectories. The European Union's Common Agricultural Policy (CAP) has changed substantially over the last three decades in response to emerging policy concerns by adding new layers. This succession of reforms proved durable and resilient to reversal in the lead‐up to the 2013 CAP reform when institutional and political circumstances changed.