Developmental validation of RSID™-Semen: a lateral flow immunochromatographic strip test for the forensic detection of human semen

Abstract: Tests for the identification of semen commonly involve the microscopic visualization of spermatozoa or assays for the presence of seminal markers such as acid phosphatase (AP) or prostate‐specific antigen (PSA). Here, we describe the rapid stain identification kit for the identification of semen (RSID?‐Semen), a lateral flow immunochromatographic strip test that uses two antihuman semenogelin monoclonal antibodies to detect the presence of semenogelin. The RSID?‐Semen strip is specific for human semen, detecting <2.5 nL of semen, and does not cross‐react with other human or nonhuman tissues tested. RSID?‐Semen is more sensitive with certain forensic evidence samples containing mixtures of vaginal secretions and semen than either of the commercially available PSA‐based forensic semen detection tests or tests that measure AP activity that were tested in parallel. The RSID?‐Semen kit also allows sampling a fraction of a questioned stain while retaining the majority of the sample for further processing through short tandem repeat analysis.     

Patterns of Onset and Decline Among Terrorist Organizations

Despite considerable speculation among terrorism researchers regarding the conditions leading to organizational desistance from terrorism, quantitative analysis of terrorism frequently focuses on terrorist attacks as the unit of analysis, resulting in a near complete absence of analyses of terrorist organizations themselves. Moreover, research on organizations that engage in terrorism has generally been limited to case studies of individual organizations. Toward a more general understanding of what conditions predict organizational desistance from terrorism, this study uses newly available data from the Global Terrorism Database to analyze the terrorist activity of 557 organizations that were active for at least 365 days between 1970 and 2008. Much like research on conventional crime, prior research on terrorism has focused almost exclusively on the onset of criminal behavior and has neglected determinants of declining activity. Here I use group-based trajectory models to investigate patterns of decline in organization-level terrorist activity. In particular I examine how patterns of onset relate to patterns of decline among these organizations. I first estimate the trajectory models for the organizations’ frequency of attacks, and then calculate the annual ratio of attacks to attacks-at-peak for each organization in order to isolate patterns of decline, independent of the magnitude of activity. I then repeat the trajectory analysis to determine if the relative shape of the organizational trajectory has significance beyond the overall frequency of attacks. I find that the speed and magnitude of an organization’s emergence are correlated with its longevity such that those organizations characterized by rapid onset are two to three times more likely than those characterized by moderate onset to reach moderate or high levels of attacks per year. Likewise, as the rate and overall volume of attacks at onset increase, so does the likelihood that the group will follow a persistent pattern of decline. I conclude with a discussion of the implications of patterns of decline among terrorist organizations for research and policy.     

Balance of Power or the State-to-Nation Balance: Explaining Middle East War-Propensity

The Middle East is one of the most war-prone regions in the international system. What is the most powerful explanation of the war-propensity of this region? I argue that neither realism nor liberalism are able to account for variations in regional war-proneness. Instead, I advance an alternative explanation based on the concept of the state-to-nation balance in the region. This balance refers to the degree of congruence between the division of the region into territorial states and the national aspirations and political identifications of the region's peoples. The balance also refers to the prevalence of strong versus weak states in the region. Thus, I explain the Middle East's high war-proneness by focusing on its relatively low level of state-to-nation balance. This imbalance has led to a powerful combination of revisionist ideologies and state incoherence. While other regions suffer from state incoherence, powerful revisionist nationalist forces, notably pan-nationalist and irredentists (the “Greater State”), aggravate this problem in the Middle East. These revisionist forces are often transborder and are especially powerful in the Middle East because of the high degree of external/transborder incongruence in comparison with all other regions. The combination of nationalist revisionism and state incoherence has made the Middle East more prone to violence than most other regions.     

Incidental findings in human subjects research: what do investigators owe research participants?

The use of brain imaging technology as a common tool of research has spawned concern and debate over how investigators should respond to incidental findings discovered in the course of research. In this article, we argue that investigators have an obligation to respond to incidental findings in view of their entering into a professional relationship with research participants in which they are granted privileged access to private information with potential relevance to participants' health. We discuss the scope and limits of this professional obligation to respond to incidental findings, bearing in mind that the relationship between investigators and research participants differs fundamentally from the doctor-patient relationship.     

Agendas and sincerity: a second response to Schwartz

An Ordeshook-Schwartz agenda tree requires a voting theorist to assign a unique “ostensive alternative” to each node, but under some non-pairwise agendas there is no evident principle by which to do this. Therefore Ordeshook-Schwartz sincere voting is not clearly defined under all types of agendas. Farquharson-style agenda trees sidestep this problem and allow one or more definitions of sincere voting under every type of agenda.