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51.
Michael T. Truver PhD Michele M. Crosby PhD Alex T. Gillette MS Sara C. Brogan BS Jennifer L. Hoyer MS Chris W. Chronister PhD Wilson A. Broussard MD Russell S. Vega MD Bruce A. Goldberger PhD 《Journal of forensic sciences》2023,68(4):1419-1424
Novel synthetic opioids contribute considerably to the opioid epidemic, especially with the frequent emergence of structurally similar compounds. This case report describes a fatal intoxication involving 2-methyl AP-237. A 54-year-old Caucasian male was found deceased from an apparent drug overdose. A plastic container labeled “2MAP” and a cut straw were found in the decedent's backpack at the scene. A white substance found in the container tested positive for fentanyl by field testing. According to his medical history, the decedent was treated for a drug overdose 3 years prior to his death. With no diagnostic findings at autopsy, the case was submitted for toxicological analysis. An unknown substance was detected in peripheral blood and urine using gas chromatography with nitrogen phosphorous detection (GC-NPD). Further testing was conducted using gas chromatography–mass spectrometry (GC–MS) and liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-QTOF-MS) which confirmed the presence of 2-methyl AP-237 and potential metabolites in blood and urine. Quantitation by GC-NPD revealed concentrations of 2-methyl AP-237 in blood and urine at 480 ng/mL and 4200 ng/mL, respectively. The toxicological analysis also identified and quantitated alprazolam in the blood at 55 ng/mL. Additionally, the metabolism of 2-methyl AP-237 was investigated and three hydroxylated metabolites were identified in peripheral blood and urine. Limited literature is available for the detection and quantitation of 2-methyl AP-237 in postmortem specimens. Given the toxicological findings with unremarkable autopsy findings, this case is an example of a fatal intoxication involving 2-methyl AP-237. 相似文献
52.
Jessica Skinner PhD Natalie Langley PhD Malin Joseph MS James Herrick MSA Robert Brown BS Brian Waletzki BS Peter Goguen Dipl T Loukham Shyamsunder PhD Subramaniam Rajan PhD 《Journal of forensic sciences》2023,68(3):757-767
Forensic fractographic features of bone reliably establish crack propagation in perimortem injuries. We investigated if similar fracture surface features characterize postmortem fractures. Experimentally induced peri- and postmortem fractures were used to assess if fractographic features vary as bone elasticity decreases during the postmortem interval (PMI). Thirty-seven unembalmed, defleshed human femoral shafts from males and females aged 33–81 years were fractured at varying PMIs with a drop test frame using a three-point bending setup and recorded with a high-speed camera. Vital statistics, cause of death, PMI length, temperature, humidity, collagen percentage, water loss, fracture energy, and fractography scores were recorded for each sample. Results showed that fractographic features associated with perimortem fractures were expressed in PMIs up to 40,600 accumulated degree hours (ADH), or 60 warm weather days. Hackle was the most consistently expressed feature, occurring in all fractures regardless of ADH. The most variable characteristics were wake features (78.4%) and arrest ridges (70.3%). Collagen percentage did not correlate strongly with ADH (r = −0.04, p = 0.81); however, there was a strong significant correlation between ADH and water loss (r = 0.74, p < 0.001). Multinomial logistic regression showed no association between fractographic feature expression and ADH or collagen percentage. In conclusion, forensic fractographic features reliably determine initiation and directionality of crack propagation in experimentally induced PMIs up to 40,600 ADH, demonstrating the utility of this method into the recent postmortem interval. This expression of reliable fractographic features throughout the early PMI intimates these characteristics may not be useful standalone features for discerning peri- versus postmortem fractures. 相似文献
53.
Evaluation of cannabinoid concentrations in products from the legal cannabis market has been fraught with uncertainty. The lack of standardized testing methodology and the susceptibility of cannabinoids to degradation under certain storage conditions complicates the efforts to assess total tetrahydrocannabinol (THC) levels across wide geographic areas. There are few peer-reviewed surveys of cannabinoid concentrations in regulated products. Those that have been done have not characterized the effects of differences in analytical methodology, sample population, and storage conditions. Viridis Laboratories, which operates two cannabis safety compliance facilities in Michigan, has analyzed over 34,000 cannabis products throughout 2021 and 2022 before the sale in the regulated market. Fifteen cannabinoids in cannabis flower, concentrates, and infused products were tested using methanolic extraction and analysis by high-performance liquid chromatography with diode-array detection. Methods were validated before use, and the flower analysis procedure was certified by the Association of Analytical Collaboration. All the samples were tested before submission for sale and therefore had not undergone prolonged storage. The results are compared with those seen in other states as well as in the illicit market. Total THC levels in cannabis flower from the regulated market are significantly higher than those seen in illicit products. The distribution of cannabinoid levels is similar in flowers intended for either the medicinal or adult-use markets, with an average potency of 18%–23% of total THC. Total THC in concentrates averages up to 82%. Other cannabinoids are observed at significant levels, mostly in products specifically formulated to contain them. These results may act as a benchmark for potency levels in the regulated market. 相似文献
54.
Christopher J. Katilie BS Lauryn E. DeGreeff PhD Caitlin E. Sharpes MS Eric M. Best PhD Patricia E. Buckley PhD Jenna D. Gadberry BS Michele N. Maughan PhD 《Journal of forensic sciences》2023,68(6):2021-2036
While canines are most commonly trained to detect traditional explosives, such as nitroaromatics and smokeless powders, homemade explosives (HMEs), such as fuel–oxidizer mixtures, are arguably a greater threat. As such, it is imperative that canines are sufficiently trained in the detection of such HMEs. The training aid delivery device (TADD) is a primary containment device that has been used to house HMEs and HME components for canine detection training purposes. This research assesses the odor release from HME components, ammonium nitrate (AN), urea nitrate (UN), and potassium chlorate (PC), housed in TADDs. Canine odor recognition tests (ORTs) were used with analytical data to determine the detectability of TADDs containing AN, UN, or PC. Headspace analysis by gas chromatography/mass spectrometry (GC/MS) with solid-phase microextraction (SPME) or online cryotrapping were used to measure ammonia or chlorine, as well as other unwanted odorants, emanating from bulk AN, UN, and PC in TADDs over 28 weeks. The analytical data showed variation in the amount of ammonia and chlorine over time, with ammonia from AN and UN decreasing slowly over time and the abundance of chlorine from PC TADDs dependent on the frequency of exposure to ambient air. Even with these variations in odor abundance, canines previously trained to detect bulk explosive HME components were able to detect all three targets in glass and plastic TADDs for at least 18 months after loading. Detection proficiency ranged from 64% to 100% and was not found to be dependent on either age of material. 相似文献
55.
Fabiana de Moura MS Mariana C. C. Diniz BS Yuri Machado PhD Cláudia D. R. Ricoy BS Evandro Piccin PhD 《Journal of forensic sciences》2023,68(4):1198-1205
This work presents a data survey regarding the qualitative chemical analysis of drugs seized by the Police in the state of Minas Gerais between July 2017 and June 2022, including an evaluation of labeling of 265 samples of anabolic androgenic steroids (AAS) seized in 2020. The Active Pharmaceutical Ingredients (API) present in the samples were identified through chemical analysis and classified by system Anatomical Therapeutic Chemical (ATC) methods. Analysis of the labeling information for 265 samples of AAS followed the guidance of legislation RDC 71 (2009) from ANVISA. For this study 6355 seized pharmaceuticals underwent qualitative chemical analysis that corresponded to 7739 APIs successfully identified and classified. Among the components studied AAS, psychostimulants, anesthetics, and analgesics were the most commonly examined. AAS seized and tested increased by over 100% and for the majority of the samples analyzed were found to not match the labeling on the packaging. In the meantime, anti-obesity drugs presented a prominent increase of 400% from 2020/1 to 2021/2, during covid-19 quarantine. Seized pharmaceuticals and tests can support information in the planning of public health and safety policies. 相似文献
56.
57.
The heightened threat of terrorism in the West has resulted in more power being granted to police. However, new anti-terror laws and heavy-handed policing practices can stigmatize Muslim communities. Using survey data from 800 Australian Muslims this paper examines whether procedural justice policing in counter-terrorism enhances Muslims’ feelings of social inclusion, and promotes their intentions to report terror threats to police. Of interest is how procedural justice influences Muslims who feel less socially included. Three competing theoretical frameworks differ in the predictions they make about when and why procedural justice influences excluded groups. This paper considers each framework and discusses how each explains the relationships between our variables of interest. Our findings show that procedural justice is positively associated with social inclusion and intentions to report terror threats to police. Findings also show that social inclusion both moderates and partially mediates the effect of procedural justice on reporting intentions. 相似文献
58.
Emma Murphy 《The international spectator : a quarterly journal of the Istituto affari internazionali》2018,53(2):21-37
The securitisation of youth as a social category has been well-documented. For the South and East Mediterranean (SEM) countries, moral panics over demographic youth bulges, Islamist radicalisation and protracted conflicts have placed youth centre-stage as a threat to the security of states and societies. Rejecting such assertions as themselves being what Foucault might have termed ‘technologies of power’ in a neoliberal order, and instead taking a critical approach to security, the spotlight is turned towards youth themselves as the referent object of study. This reveals the multidimensional hyper-precarity and insecuritisation of young peoples’ lives which derive from that same neoliberal economic order and the political structures that sustain it in the SEM countries. The finding resonates with other studies of new, insecure, formats for adulthood in Africa and suggests that we should look at the insecurity of young people today to understand global neoliberal futures in countries beyond the post-industrial ‘core’. 相似文献
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60.
Patricia Murphy 《The Journal of law, medicine & ethics》1997,25(1):65-66
Anne J. Davis et al., Ethical Dilemmas & Nursing Practice (Stamford: Appleton & Lange, 4th ed., 1997): 275 pp., ISBN 0-8385-2283-1 (paper), $34.95. To order call 1-800-423-1359. 相似文献