A fatal interaction of methocarbamol and ethanol in an accidental poisoning

A case is presented of a fatal drug interaction caused by ingestion of methocarbamol (Robaxin) and ethanol. Methocarbamol is a carbamate derivative used as a muscle relaxant with sedative effects. Therapeutic concentrations of methocarbamol are reported to be 24 to 41 micrograms/mL. Biological fluids were screened for ethanol using the Abbott TDx system and quantitated by gas-liquid chromatography (GLC). Determination of methocarbamol concentrations in biological tissue homogenates and fluids were obtained by colorimetric analysis of diazotized methocarbamol. Blood ethanol concentration was 135 mg/dL (0.135% w/v) and urine ethanol was 249 mg/dL (0.249% w/v). Methocarbamol concentrations were: blood, 257 micrograms/mL; bile, 927 micrograms/L; urine, 255 micrograms/L; gastric, 3.7 g; liver, 459 micrograms/g; and kidney, 83 micrograms/g. The combination of ethanol and carbamates is contraindicated since acute alcohol intoxication combined with carbamate usage can lead to combined central nervous system depression as a result of the interactive sedative-hypnotic properties of the compounds.     

Liver histopathology in autopsied drug-addicts

Liver specimens of 150 randomly selected autopsied drug addicts from the province of Milan (Italy) were studied using light microscopy, polarized light and immunohistochemical methods. Simple histological changes and the main diagnoses are described. The main histological diagnoses in order of frequency were: non-specific reactive hepatitis (NSRH) (52%), chronic aggressive hepatitis (CAH) (24%), acute hepatitis (AH) (12%), normal liver (6%), steatosis only (3.3%) and cirrhosis (2%). In 24 cases (16%) one or more viral antigens (HBsAg, HBcAg and Delta Ag) were detected in hepatocytes by immunohistochemical methods. Three liver specimens revealed epithelioid cell granulomas, but in no case was birefringent material identified in the liver. AH and CAH were more frequent in the group of livers with viral antigens. Our histological and immunohistochemical data confirm the current opinion that, in most cases, liver pathology in drug addicts has a viral aetiology, while no significant pathogenic role has been identified for drugs, alcohol or contaminants. Recurrent infections by one or several viruses possibly explain the relatively peculiar histological features of hepatitis in drug addicts.     

Families, murder, and insanity: a psychiatric review of paternal neonaticide

Neonaticide is the killing of a newborn within the first 24 h of life. Although relatively uncommon, numerous cases of maternal neonaticide have been reported. To date, only two cases of paternal neonaticide have appeared in the literature. The authors review neonaticide and present two new case reports of paternal neonaticide. A psychodynamic explanation of paternal neonaticide is formulated. A new definition for neonaticide, more consistent with biological and psychological determinants, is suggested.     

SPECIALIZATION IN JUVENILE COURT CAREERS

The study of specialization in offending careers is relevant to the key theoretical issue of whether different types of offending reject only one underlying theoretical construct (such as delinquent tendency) or several different constructs. This research improves on previous studies of specialization in offending careers in three ways: (1) It is based on the complete juvenile court careers of a very large sample of offenders (nearly 70,000). (2) It uses a fine-grained classification of 21 offense types. (3) It uses a new measure of the strength of specialization, the Forward Specialization Coefficient (FSC). Both transition matrices and offending careers are studied.
The major findings from the transition matrices are (1) there was a small but significant degree of specialization in offending superimposed on a great deal of versatility: (2) the degree of specialization tended to increase with successive referrals, and this was not due to more versatile offenders dropping out: and (3) the relative extent to which offenders specialized in different offenses held for two jurisdictions (Maricopa County, Arizona, and Utah), both sexes, and all ages.
The analyses of offending careers showed that the most specialized offenses were runaway, burglary, motor vehicle theft, liquor violations, incorrigibility, curfew, truancy, and drugs. Nearly 20 percent of the offenders were identified as specialists. The conclusion is that, while offending was versatile to a first approximation, delinquency theories should attempt to explain specialization and specialists in order to yield more accurate quantitative predictions about offending careers.     

The use of monoclonal antibodies in analyzing blood and saliva stains by the mixed agglutination reaction

Possible use of monoclonal antibodies anti-A, anti-B, anti-M and anti-N in mixed agglutination reaction during the analysis of blood and secretion traces of different age is demonstrated. Dependence of antigen A and B detection in salivary traces on secretory type was determined.