Performance of the SNPforID 52 SNP-plex assay in paternity testing

The performance of a multiplex assay with 52 autosomal single nucleotide polymorphisms (SNPs) developed for human identification was tested on 124 mother–child–father trios. The typical paternity indices (PIs) were 10⁵–10⁶ for the trios and 10³–10⁴ for the child–father duos. Using the SNP profiles from the randomly selected trios and 700 previously typed individuals, a total of 83,096 comparisons between mother, child and an unrelated man were performed. On average, 9–10 mismatches per comparison were detected. Four mismatches were genetic inconsistencies and 5–6 mismatches were opposite homozygosities. In only two of the 83,096 comparisons did an unrelated man match perfectly to a mother–child duo, and in both cases the PI of the true father was much higher than the PI of the unrelated man. The trios were also typed for 15 short tandem repeats (STRs) and seven variable number of tandem repeats (VNTRs). The typical PIs based on 15 STRs or seven VNTRs were 5–50 times higher than the typical PIs based on 52 SNPs. Six mutations in tandem repeats were detected among the randomly selected trios. In contrast, there was not found any mutations in the SNP loci. The results showed that the 52 SNP-plex assay is a very useful alternative to currently used methods in relationship testing. The usefulness of SNP markers with low mutation rates in paternity and immigration casework is discussed.     

The weight of history: child protection and parenting with a disability in 20th Century Iceland

ABSTRACT

This contribution focuses on four periods in Iceland, from the early twentieth century until the time of writing, in order to document and analyse the struggles of people with intellectual disabilities to marry, have a family and maintain custody of their children. Each period is linked to specific pieces of legislation that governed the bodies and lives of disabled people and reflected larger social norms concerning issues of family life and parenthood. An emphasis is placed upon the perspective of contemporary critical disability studies in analysing the historical development of this struggle, and the voices of those who experienced this struggle first-hand, drawn from a number of research projects conducted in Iceland. Our main contention is that the weight of history still comes to bear upon matters of parenting and family life, even in the most recent shift toward a human rights approach to disability. There remains a strong socio-cultural resistance toward parenting with an intellectual disability, rooted in the ideology of early twentieth-century eugenics. Our goal is to document the development of these phases throughout the twentieth century in Iceland in order to illustrate how older ideas and prejudices still inform contemporary child protection practices concerning parents with disabilities.     

Understanding the next act

Abstract

This essay argues that the practical difficulties of dealing effectively with terrorism reveal a basic problem in the terms of conventional moral understanding. Specifically, current moral principles permit us to condemn any act of terrorism as categorically unjustifiable only in terms which impose crippling restrictions upon the range of justifiable counterterrorist measures. This problem arises from an abstract individualism which pervades current moral and political thought. If this abstract individualism is rejected, then it is possible to construe acts of terrorism as savage in a special sense, insofar as they rejct the prior moral authority of the community to determine its own standards. On this basis, such acts may be condemned as inherently incapable of moral justification, and in terms which license vigorous counterterrorist measures.     

Partisanship,Ministers, and Biotechnology Policy

Research in public policy and political economy has provided many insights in the evolution of public resistance against genetically modified organisms (GMOs) in the last two decades. But how does the partisan composition of a government, its programmatic orientation and the allocation of cabinet offices affect policy making in this specific area? We argue that the regulation of GMOs is determined by the ideological orientation of governments and the presence of parties with a specific ideological background in the cabinet. In addition, we hypothesize that the parties' control over relevant cabinet posts matter for GMO regulation. We test our hypotheses by using an innovative dataset that contains information on biotechnology regulation outputs of European governments in the time period from 1996 until 2013, the partisan composition and policy‐area specific positions of governments, and the party affiliation of key cabinet actors. The results show that the presence of a Christian democratic party in a cabinet increases the chances of a ban on biotech crops, in particular if it controls the Ministry of the Environment.     

Law, Diagram, Film: Critique Exhausted

What potential can be found in the work of Deleuze and Guattari for critical legal scholarship? The authors argue that their work can be deployed to re-think ??critique?? by directly addressing the place and role of the ??critic??. It is argued that the continued commitment to a stance of ??resistance?? in CLS is underpinned by never-ending dualisms which, if not confronted and replaced, can only make CLS ever more redundant. The authors ask: ??what is critique beyond the dualism of power and resistance, of state and nomad??? This question arises from a belief that critique is still capable of being effective, but only if there is the courage to experiment, and to think creatively. In this sense, the ??exhaustion?? of critique is framed as an opportunity to re-think and re-engage with the politics of law. The paper diagrams, through image and film, a critical thought: the potential of the artisan. Film is utilised not as representation, nor as illustration, but as a thinking mind in its own right, through which questions relating to the state, political action, and creative thinking can be (re)framed. Such a re-framing is essential, it is argued, for an engagement with the emergence of societies of control.     

Improving eyewitness identification accuracy by screening out those who say they don't know

Improving eyewitness identification evidence remains a key priority for research. Basic laboratory research has consistently demonstrated that allowing participants to withhold answers about which they are unsure leads to improved accuracy. Surprisingly, this approach has not been the subject of comprehensive investigation in the eyewitness identification literature. In this article, we explored the utility of allowing uncertain witnesses to opt out of an identification decision, by providing an explicit don't know option. Further, we contrasted the rate of use of this explicit option with the frequency that participants spontaneously withheld a decision when asked to respond in their own words. Four hundred and twenty participants witnessed a mock crime video before being presented with a showup of the perpetrator or an innocent suspect. Participants were tested either immediately or after a 3-week delay, with one of the three report options: Participants either made their choice in their own words (spontaneous report), chose between identifying and rejecting the showup (forced-report), or chose between identification, rejection and don't know (free-report). Only 2.2% of witnesses spontaneously used a don't know response, compared to 19.3% who used it when the option was explicit. Compared with the forced-report decisions, free-report decisions were more accurate, more diagnostic of the suspect's guilt or innocence, and came at no cost to the number of correct decisions rendered. These data suggest that utilisation of an explicit don't know option may be of practical value.