Diagnosis of sudden unexplained death in epilepsy by immunohistochemical staining for prolactin in cerebral vessels

Sudden unexplained death in epilepsy occurs when epilepsy patients die suddenly and unexpectedly in the absence of recent tonic-clonic seizure activity. There is currently no known reliable indicator of acutely lethal seizure activity. Clinical studies record a relationship between recent (within 10-40 minutes) seizure activity and elevated serum prolactin levels, and postictal elevation of prolactin within peripheral vessels has proved clinically useful in determining recent seizure activity. The authors hypothesized that elevated prolactin could be detected in cerebral vessels by immunohistochemical stains, serving as a marker for sudden unexplained death in epilepsy. They conducted a retrospective study of individuals who died in their jurisdiction during the 14 years from 1986 through 1999. The study contained one group of individuals who died of sudden unexplained death in epilepsy, a group with epilepsy who died of some other cause, and a control group whose members died rapidly of a gunshot wound of the torso. Sections of hippocampus and neocortex were obtained and stained with a polyclonal prolactin antibody. No significant difference in the level of immunostaining for prolactin in cerebral vessels was found between the experimental and control groups. A review of the protocols used indicates that revision of certain aspects may provide better immunostaining and more conclusive results.     

Government support of technical progress: Lessons from history

In the past, the U.S. government has been involved in various programs to support technical progress. The record of such programs in seven industries offers important guidelines. The economist's usual presumption that government support for such activities should be concentrated on those cases in which there is palpable market failure proves much too simple. Programs that stand the best chance of success are those in which the government itself is a dominant customer for the product concerned, those that do not require the government to determine what the commercial market wants, and those that do not directly threaten the relative position of competing firms in the industry. Some of the most successful programs have been positioned between basic research on the one hand and commercial application on the other.     

Bureaucratizing Democracy, Democratizing Bureaucracy

This article analyzes the relationship between how rationality is conceived and how democracy is practiced in the Bureau of Reclamation, a water development agency in the Department of Interior. The efforts of some inside the agency to institutionalize rational decision-making models, partly in response to new environmental law, expanded the number and range of interest groups that participated in its decisions fry incorporating their preferences into their models for evaluating plans. But the terms under which people could express their values and interests were strictly controlled in ways that some felt misrepresented their concerns. How we conceive of rationality has important implications for how and which people are included in bureaucratic decision making.     

Are IMF lending programs good or bad for democracy?

Have IMF lending programs undermined political democracy in borrowing countries? Building on the extensive literature on conditional lending, we outline several pathways through which IMF program participation might affect the levels of democracy in borrowing countries - including a new variant that suggests the possibility of a positive association between lending program participation and democracy scores. In order to test the argument we assemble annual data from 120 low- and middle-income countries observed (at maximum) in each year between 1971 and 2007. We use three strategies - genetic matching, instrumental variables, and difference-in-differences estimation - to better estimate the direction and size of the statistical association between participation in IMF lending programs and the level of democracy. We find evidence for modest but definitively positive conditional differences in the democracy scores of participating and non-participating countries.     

Evaluating the economic impact of a special credit programme: KIK/KMKP in Indonesia

This article discusses a study of the economic impact of Indonesia's KIK/KMKP programme of special credits for small‐scale enterprises. Our major focus is on how to measure economic impact. It discusses the concept of ‘impact’, the survey design, the statistical framework, and the practical problems of implementation, and briefly summarises the findings. We believe that our methodology generated reasonably reliable data and fundamentally sound estimates of the credit programme's direct impact on employment, output and income.     

A Governance Reform Proposal: Improving Bus Transit Operations in Los Angeles

This article examines key governing issues related to Los Angeles transit operations. The study uses empirical data from the National Transit Database and personal interviews conducted with transit agency officials. Based on technical analysis and evaluation, the authors call for empowering council of governments and small cities to address interagency/intersector coordination and political equity issues, downsizing the Los Angeles County Metropolitan Transportation Authority Headquarters and strengthening autonomy of the “Service Sectors” to better streamline transit operation issues, abolishing small municipal transit operators to refine bus fleet size distribution, and enhancing transit service privatization to yield a better cost efficiency.