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61.
Ontogeny of Size and Shape Sexual Dimorphism in the Pubis: A Multislice Computed Tomography Study by Geometric Morphometry 下载免费PDF全文
Marie Faruch Bilfeld M.D. Ph.D. Fabrice Dedouit M.D. Ph.D. Nicolas Sans M.D. Ph.D. Hervé Rousseau M.D. Ph.D. Daniel Rougé M.D. Ph.D. Norbert Telmon M.D. Ph.D. 《Journal of forensic sciences》2015,60(5):1121-1128
Few studies have been conducted to determine sex differences in the immature coxal bone and the results were often contradictory. The authors studied sexual dimorphic differences of the pubis using geometric morphometric analysis of five osteometric landmarks recorded by multislice computed tomography (MSCT), based on three‐dimensional reconstructions of 188 children (95 boys, 93 girls) living in the region of Toulouse, southwestern France, ranging in age from 1 to 18 years old. They used geometric morphometric methodology first to test sexual dimorphism in size (centroid size) and shape (Procrustes residuals) and second to examine patterns of shape change with age (development) and size change with age (growth). Based on statistical significance test results, the pubic shape became sexually dimorphic at 13 years old, although visible shape differences were observed as early as 9 years old. This work showed that the trajectories of pubis shape (development) and size (growth) differed throughout ontogeny and between sexes. 相似文献
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Françoise Nicolas 《Economic Change and Restructuring》2008,41(4):345-367
A widely held consensus view claims that East Asia has been shifting recently from a market-led to an institution-based form of regional economic integration, primarily as a result of the 1997–1998 financial crisis. Next to post-crisis financial cooperation schemes under the ASEAN+3, the surge of Regional Trade Agreements (RTAs) involving East Asian countries is thought by some to further substantiate this claim. The objective of the paper is to question the validity of this claim. By examining the current state of play of economic cooperation, in the financial and monetary areas as well as in the trade sphere, the paper highlights the limitations of the formal regional integration movement in East Asia to date, as well as the vastly different dynamics underlying the financial and trade developments. It also explores the changing nature of intra-regional trade and investment linkages and concludes that this new form of interdependence may be instrumental in changing the trade-offs of formal regional economic schemes. 相似文献
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Nicolas Blarel 《India Review》2019,18(5):582-595
ABSTRACTDo Indian regional parties influence foreign policy and under which conditions? Some foreign policy studies have shown that certain coalition-building configurations have facilitated the inclusion of the concerns of small parties in the foreign policy debate. Other works have looked at the role of decentralization and federal power-arrangement in providing more control to political sub-units over the external affairs of a state. Those separate scholarships provide interesting insights to account for the multi-level nature of coalition-building in a federal and pluralistic polity like India. Bridging these two literatures, I argue that the interdependence of regional and national coalition building processes (visible in federal settings) create locked-in alliances between national parties and regional parties which affect foreign policymaking. In these contexts, India’s national parties have to, under certain conditions, take into account the preferences of regional parties when designing foreign policies. This article looks at the hypothesized causal mechanisms and expectations through two illustrative case studies of India’s foreign policy. 相似文献
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Leuenberger N Saugy J Mortensen RB Schatz PJ Giraud S Saugy M 《Forensic science international》2011,213(1-3):15-19
Since the 1990's, cheating athletes have abused substances to increase their oxygen transport capabilities; among these substances, recombinant EPO is the most well known. Currently, other investigational pharmaceutical products are able to produce an effect similar to EPO but without having chemical structures related to EPO; these are the synthetic erythropoiesis stimulating agents (ESAs). Peginesatide (also known as Hematide?) is being developed by Affymax and Takeda and, if approved by regulatory authorities, could soon be released on the international market. To detect potential athletic abuse of this product and deter athletes who consider cheating, we initiated a collaboration to implement a detection test for anti-doping purposes. Peginesatide is a synthetic, PEGylated, investigational, peptide-based erythropoiesis-stimulating agent that is designed and engineered to stimulate specifically the erythropoietin receptor dimer that governs erythropoiesis. It is undetectable using current anti-doping tests due to its lack of sequence homology to EPO. To detect and deter potential abuse of peginesatide, we initiated an industry/antidoping laboratory collaboration to develop and validate screening and confirmation assays so that they would be available before peginesatide reaches the market. We describe a screening ELISA and a confirmation assay consisting of immune-purification followed by separation with SDS-PAGE and revelation with Western double blotting. Both assays can detect 0.5 ng/mL concentrations of peginesatide in blood samples, enabling detection for several days after administration of a physiologically relevant dose. This initial report describes experimental characterization of these assays, including testing with a blinded set of samples from a clinical study conducted in healthy volunteers. 相似文献
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de Sadeleer N 《European journal of health law》2012,19(1):3-28
In the light of new case law development, this article examines whether national restrictions on the online sale of pharmaceuticals and medical devices such as contact lenses are consistent either with EU secondary law, either with Article 34 TFEU that prohibits measures having equivalent effect to quantitative restrictions on imports. In particular, this article focuses on an analysis of two judgments on this important issue delivered by the Court of Justice of the European Union in 2003 and 2010, namely the Deutscher Apothekerverband decision and the Ker-Optika decision. 相似文献
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Franchitto N Minville V Dédouit F Telmon N Rougé D 《Journal of forensic sciences》2012,57(4):1120-1123
Amniotic fluid embolism (AFE) continues to be one of the most feared complications of pregnancy. A healthy 32-year-old woman died during delivery after a normal 39-week third pregnancy. The family filed a complaint with a criminal court as the causes of death appeared unclear. No risk factor associated with AFE was identified. Clinical presentation was typical, including sudden onset of cardiovascular and respiratory symptoms. Autopsy confirmed the histological diagnosis of amniotic embolism and excluded an iatrogenic cause of death or anesthetic malpractice. This article highlights the value of both antemortem records and histological features in establishing the diagnosis of AFE and demonstrates the fundamental importance of autopsy in an unexpected death related directly or indirectly to a medical procedure. 相似文献