Bile analysis of drugs in postmortem cases

Bile is, in certain cases, collected together with blood from different sites (heart, brain, femoral), urine and other organs or matrices. This study reports comparative results obtained from the analysis of blood and bile for different drugs found: acetaminophen, amphetamine and related compounds, several antidepressants, several benzodiazepines, cocaine and its metabolites, dextropropoxyphene and its metabolite, hydroxyzine, methadone and metabolite, morphine and codeine, levomepromazine, thioridazine, propranolol, tramadol and its metabolite. Several findings are presented: (1) There were no significant differences in the levels of the compounds among the samples of blood obtained from different sites. (2) Levels in bile are generally several fold higher than those in blood. The mean bile to blood ratios vary from about 1 (for acetaminophen, amphetamine) to about 2000 (for desmethylclobazam). (3) In certain cases (16 over 44), although the drug or its metabolite was not detected in blood from different sites, it was detected in bile. As other authors had advocated, it is very useful to ask the pathologist to take the gall bladder with its contents together with the other samples, in order that the sample of bile can be used in the comprehensive toxicological analysis and therefore be complementary to the other fluids or matrices. An additional advantage for using bile is that the concentrations of drugs or their metabolites are generally several fold higher than their blood concentrations.     

Polymorphism at fifteen hypervariable microsatellite loci in four populations of Maharashtra,India

Polymorphism at 15 microsatellite loci was studied in four predominant, endogamous populations of Maharashtra state in India. The studied population included Marathas, Desasth Brahmins, Chitpavan Brahmins and Dhangars; all of whom belong to Marathi speaking linguistic group of India. The distribution of the allele pattern at 13 tetranucleotide repeat and two pentanucleotide repeat of Powerplex 16 System portrays that these markers are highly polymorphic and thus, informative in human identification and understanding diversity in the addressed populations.     

Genetic variation at 15 autosomal microsatellite loci in the three highly endogamous tribal populations of Orissa,India

Although microsatellite diversity in autosomal chromosomes has been extensively described for many of the Indian populations, there is still a lacuna left on information about the genetic diversity of tribal populations. This paper reports the genetic data on the three tribal populations belonging to the Austroloid ethnic group from Orissa (Juang, Paroja and Saora). The 15 STR (D3S1358, THO1, D21S11, D18S51, PentaE, D5S818, D13S317, D7S820, D16S539, CSF1PO, PentaD, vWA, D8S1179, TPOX, FGA) polymorphism would help to accentuate the STR database for better understanding of population genetics and forensic applications. The microsatellites included in the system are found to be highly polymorphic, with the combined power of exclusion being greater than 0.999, in all the three investigated populations.     

Collaboration over Adaptation: The Case for Interoperable Communications in Homeland Security

Analogizing the U.S. Department of Homeland Security to a corporate conglomerate consisting of multiple, formerly independent operating units with little in common and even less history of cooperation, this response to Professor Charles Wise prescribes the "bitter medicine" of interoperable communications. The critical function of assuring homeland security and disaster preparedness cannot depend on the uncertain trajectory of adaptive response.     

Voting strength in the European Parliament: The influence of national and of partisan actors

Abstract. Most decisions by the European Parliament are taken by an absolute majority of its members. Some decisions however – such as the approval of the budget of the European Union – require a two-thirds majority. The paper analyzes the a priori voting strength of the member states when their representatives vote coherently. It is shown that the increase in votes for Germany in the 1994 reallocation enhanced its position. A less favourable effect, however, can be seen for the other large members (France, Italy, the United Kingdom, and Spain). However, since votes in the EP tend to be cast according to partisan rather than national affiliation, the relative voting power of the political groups with respect to the two quotas is also analyzed. The tool to measure this is the (normalized) Banzhaf power index, partially extended to account for connected coalitions. The paper demonstrates that the distribution of votes between the present EU member states as allocated in proportion to their population size indeed roughly corresponds to their a priori voting power. However, the relative influence of the largest political groups, the European Socialists and the European People's Party, tends to be overestimated by their share of seats in the framework of the simple majority rule, but it is considerable if the quota is two-thirds. Finally, under the two-thirds majority rule, the European Liberal, Democratic and Reformist Party as well as the small groups appear to be almost powerless. The more the EP gains political leverage – a further increase in its institutional powers is to be expected in the framework of the ongoing Intergovernmental Conference – the more the distribution of voting power between the member states and between the political groups will be a crucial factor in the shaping of EU policies.     

Popularity functions based on the partisan theory

This paper presents popularity function estimates for U.S. presidents which are based on a model in which voters' evaluations reflect an understanding of partisan reputations for differing policies.I am indebted to J.C. Siebrand, F.A.A.M. van Winden and an anonymous referee for many useful suggestions.