Overview of the seized and examined pharmaceutical in the state of Minas Gerais-Brazil by the Civil Police from 2017 to 2022: A fundamental analysis of the recent impact over the drugs market

This work presents a data survey regarding the qualitative chemical analysis of drugs seized by the Police in the state of Minas Gerais between July 2017 and June 2022, including an evaluation of labeling of 265 samples of anabolic androgenic steroids (AAS) seized in 2020. The Active Pharmaceutical Ingredients (API) present in the samples were identified through chemical analysis and classified by system Anatomical Therapeutic Chemical (ATC) methods. Analysis of the labeling information for 265 samples of AAS followed the guidance of legislation RDC 71 (2009) from ANVISA. For this study 6355 seized pharmaceuticals underwent qualitative chemical analysis that corresponded to 7739 APIs successfully identified and classified. Among the components studied AAS, psychostimulants, anesthetics, and analgesics were the most commonly examined. AAS seized and tested increased by over 100% and for the majority of the samples analyzed were found to not match the labeling on the packaging. In the meantime, anti-obesity drugs presented a prominent increase of 400% from 2020/1 to 2021/2, during covid-19 quarantine. Seized pharmaceuticals and tests can support information in the planning of public health and safety policies.     

Evaluating the discriminating power of amino acid ratios on distinguishing dark colored hair samples

Human hairs are one of the most commonly encountered items of trace evidence. Currently, conventional methods for hair analysis include microscopic comparison and DNA analysis (nuclear and mitochondrial). Each approach has its own drawbacks. Hair proteins are stable and offer an alternative to DNA testing, as demonstrated with proteomics for distinguishing humans. However, proteomics is complicated and requires identifying peptides to remain intact following harsh sample preparation methods. Alternatively, the actual amino acid content of a hair sample may also offer important identifying information and actually requires proteins and peptides to be broken down completely rather than remaining intact. This study evaluated the discriminating power of using hair amino acid ratios to differentiate hair samples from 10 unrelated individuals with dark colored hair. Hair proteins were digested, derivatized, and analyzed using gas chromatography–mass spectrometry. Amino acid ratios were calculated for each individual and comparisons using ANOVA and post-hoc pairwise t-test with Bonferroni correction were made with amino acid ratios for individuals. Overall, out of the 45 possible pairwise comparisons between all hair samples, 38 (84%) were differentiable. Out of the 36 possible pairwise comparisons between brown haired individuals, 32 (89%) were considered differentiable using univariate statistics. Multivariate statistics were also attempted but, overall, univariate models were sufficient for exclusionary purposes. These results indicate that amino acid ratio analysis can potentially be used as an exclusionary method using hair if DNA analysis cannot be performed, or to corroborate conclusions made following microscopic analysis.     

Evaluating the sensitivity,stability, and cross-reactivity of commercial fentanyl immunoassay test strips

Illicit fentanyl has flooded the United States' drug market, increasing the risk of overdose and poisonings throughout the general population and accidental exposure among law enforcement officers confiscating the increasing number of seizures. Fentanyl test strips (FTS) are used to obtain presumptive information about the presence of fentanyl in a suspected sample. However, their adoption by law enforcement personnel and seized-drug analysts has been limited because most products are advertised for urine testing, not for assays using water solutions. This study presents an evaluation of four commercial FTS: Rapid Response from BTNX, Inc.; T-Dip Fentanyl (FTY) Urine Dip Cards obtained from Amazon.com ; Premier BioDip FYL10 from Premier Biotech Inc.; and MobileDetect Fentanyl strips from DetectaChem, Inc. Performance characteristics curves were used to compare the products' sensitivity, showing that all can reliably detect fentanyl in aqueous solutions at concentrations below 1 μg/mL, with some of the tests able to reliably detect the drug at 200 ng/mL. A stability study demonstrates the performance of all four FTS brands was only slightly affected after 30 days of storage at two extreme environmental conditions. Fentanyl-related substances are also evaluated using the Rapid Response FTS, which showed high cross-reactivity with para-fluorofentanyl and acetylfentanyl, but lower with ortho-chlorofentanyl, carfentanil, and 4-ANPP. Users should be aware that FTS may give false-negative results even when potentially dangerous levels of carfentanil are present. When testing other common drugs, adulterants, and diluents frequently encountered in seized tablets, concentration-dependent results were obtained and multiple instances of false positives were recorded.     

Unlikely relations: Israel,Romania and the Egyptian–Israeli peace accord

The history of Israel's turbulent relations with the Eastern bloc nations during the Cold War has one exception, Romania. Unlike other Warsaw Pact members, Romania did not sever relations with Israel following the 1967 war. Central to these relations was Romanian Communist leader Nicolai Ceausescu, who managed to establish himself as an important figure among both Arabs and Israelis. This article will examine Romanian–Israeli relations during the 1970s and especially Ceausescu's role in the Egyptian–Israeli peace negotiations. Recent Israeli and some Romanian documents released from the Israeli State Archive and the Begin Centre reveal much about Israel's attitude towards Romania and Ceausescu's involvement in the Middle East, and serve to shed light on a heretofore neglected aspect of Israeli foreign policy. Some of the main issues to be addressed are Ceausescu's influence on Egyptian and Israeli decision makers, Israel's prime motives in maintaining a close relationship with Romania, the importance of Romanian Jewry's position to Israel's policy vis-à-vis Romania and the extent to which these relations represented a back channel that facilitated some contact with the Kremlin. All these will be examined against the larger backdrop of the Cold War and the Arab–Israeli conflict.     

Hide and seek? Israeli–Turkish relations and the Baghdad pact

The aim of this article is to address the impact of the Baghdad Pact and the Anglo-American defense system and its collapse on the Turkish–Israeli relationship from 1954 to 1958, a discussion that is absent from scholarly studies. The article will highlight the different approaches and views of the two parties and their impact on the cold war alliances and the Arab–Israeli conflict. Examining this from the perspectives of both Ankara and Jerusalem will contribute to a comprehensive study of the bilateral relations during the 1950s. Some of the main questions to be addressed are: to what extent, if at all, did the Baghdad Pact change bilateral relations between Turkey and Israel? What were Israel's main concerns? Were its suspicions of Turkey's changing policy founded? How much was Turkey influenced by Iraq's membership of the Pact and its hostile attitude toward Israel? Was Turkey's attempt to maintain reasonable relations with both Israel and Iraq a realistic aim? All these will be assessed against regional upheavals and the cold war politics with current implications.     

体系、社会和国家:理解《美韩自由贸易协定》

2007年6月,美韩双方签署了《美韩自由贸易协定》。美韩之间为什么要签署该协定?该协定对两国国内分别产生了哪些影响?该协定为何至今没能获得美国国会的通过?针对上述问题,本文结合美国贸易政策理论,从体系、国家和社会三个层面对其进行了分析。《美韩自由贸易协定》的签署及其实施,在体系层面上将会为双方带来经济、政治和战略上的多重收益,而在社会层面上却产生了不同的反应。尽管由于国内经济困难和利益集团的掣制使得协定的通过还面临不小的阻力,但基于协定所蕴含的重要价值和两国政府对此认识的高度一致,协定获得通过只是时间上的问题。     

东亚-北美经济失衡与再平衡分析

本文从国别结构和产品结构分析了20世纪90年代以来东亚—北美经济失衡的变化,认为美国贸易逆差不断扩大是其对外产业转移的结果,东亚地区贸易顺差与日俱增是其承接产业转移的结果。其中,东亚内部再次产业转移导致中国顺差迅速膨胀。为了实现东亚—北美经济再平衡,美国需要采取一些措施扩大出口,控制过度的信贷消费,并对美元采取更加负责的政策;东亚地区需要努力实现由外需驱动型向内需驱动型增长方式的转变,加快产业调整与升级,并把产业链向其他地区延伸。     

浅析韩国的绿色增长战略

绿色增长正在成为世界谋求经济社会可持续发展的重要经济模式,各国都在寻求实现绿色增长的发展战略。1997亚洲金融风暴、2008年以来的世界性经济衰退促使积极探索经济转型新路的韩国加快了战略转型的步伐。韩国政府为此提出并开始实施“低碳绿色增长战略”,制订并发表了“绿色增长国家战略与五年计划”以及相关的法规,详细阐述了韩国推进这一战略计划的长远规划、战略目标、实施计划、政策措施等,并建立了从中央到地方的组织实施机构。韩国积极推动的绿色增长战略充分揭示了其未来经济发展的基本方向,意在谋求实现经济增长方式的转变、构建未来经济长期稳定发展的新增长模式和动力。     

What the ICJ did not say about the Duty to Punish Genocide: The Missing Pieces in a Puzzle

The article focuses on the legal implications of the constructionof the International Court of Justice (ICJ or the Court) ofthe duty to punish genocide under Article VI of the Conventionon the Prevention and Punishment of the Crime of Genocide inthe Bosnia and Herzegovina v. Serbia and Montenegro judgment.It posits that the Court's discussion of the duty to punishis satisfying in terms of what it says and less satisfying interms of what it is silent about. It is satisfying in the sensethat the Court's construction of the duty to cooperate withinternational tribunals prosecuting genocide as including aduty of extradition, seems to extend beyond the plain languageof the Convention and indeed beyond the parties’ originalintent. It is not fully satisfying because the duty to prosecuteremains quite limited. It is further argued that the obligationto punish genocide as established in Article I and the obligationto prosecute genocide as established in Article VI should beunderstood as two distinct obligations. Article VI merely setsthe institutional arrangements for prosecution. Other normativesources support the conclusion that a general duty to prosecuteperpetrators of genocide or extradite them for prosecution elsewhereapplies even in those cases where the offence was not committedin the territory of a contracting state or when the offenderis prosecuted by an international court that has jurisdictionover the state where the alleged perpetrator is found.