Optimization of extraction parameters for the chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets

The extraction of impurities from illegally produced 3,4-methylenedioxymethamphetamine (MDMA) has been studied in order to optimize the parameters. Two different MDMA samples were used. Particular attention was paid to the influence of the pH, the evaporation step, and the sample storage. The method used was an extraction of impurities by diethyl ether from a buffer solution at pH 11.5, followed by gas chromatography (GC) mass spectrometric (MS) analyses after a dryness concentration under monitored conditions of the ethereal extract. Repeat extractions of the same sample gave an average relative standard deviation (RSD) of less than 8.5% within day and less than 10.5% between days.     

Determination of heroin after embalmment

A 30-year-old male died in Thailand after a scuffle. The corpse was embalmed and repatriated to France where an autopsy was performed. As usual in cases of embalmment, fluids such as blood and urine were unavailable and the toxicological analyses was performed on the bile and the liver. An overdose of heroin was determined as the cause of death. A review of the literature indicates that several drugs can be detected in fluids and tissues that contain formaldehyde. This case demonstrates that in embalmed corpses, toxicological assessment is still possible, e.g. after heroin fatalities.     

Opinion formation in foreign policy: the Swiss experience

Applying John Zaller's model of opinion formation to survey data covering 15 years (1981–95) of direct democracy in Switzerland, this paper provides a contribution to the debate about opinion formation in foreign policy. On the one hand, the Swiss experience contradicts the widespread view that citizens are poorly informed about and little interested in foreign affairs. On the other hand, direct democracy often translates into governmental defeats in this field. We address these mixed results and show that opinion formation in foreign policy is not a special case, and differs from that in domestic policy only with respect to the circumstances under which it occurs. In particular, we highlight the unusual type and level of conflict within the elite on foreign policy issues, which translates into distinct patterns of attitudes among the public.     

Arsenic speciation of two specimens of Napoleon's hair

Since 1960, it has been demonstrated by various analytical procedures that high concentrations of arsenic were present in Napoleon's hair. Various authors, indicating that the detected arsenic levels are a consequence of external contamination, have challenged the results of these examinations. We have tested two strands of hair, referenced as Noverraz and Grand Maréchal Bertrand. Samples were incubated 6 h in water at 90 °C, and arsenic speciation was carried out by HPLC–ICP/MS. The residue was injected on a cation-exchange PRP-X200 column that allows the detection of arsenobetaine and on an anion-exchange PRP-X100 column to test for the mineral forms. In these conditions, the inorganic species As(III), As(V) and their metabolites (DMA and MMA) were separated. Analysis of hair samples highlighted massive amounts of total arsenic (42.1 and 37.4 ng/mg). Arsenical species found in the two samples of analyzed hair are distributed in the following: As(III) 31.1 and 44.7%; As(V) 66.3 and 53.2%; DMA 0.42 and 0.15%. Traces of MMA were detected, and 2% of the species could not be identified. These results prove that more than 97% of the arsenic found in the hair of Napoleon is in inorganic form, which is consistent with a chronic intoxication to arsenic.     

Direct democracy in Switzerland: Do elites matter?

Abstract. Direct democratic institutions, while centrepieces of the Swiss political system, find themselves under attack. In this article, we challenge the widespread criticism that popular rights increasingly limit the political elite's control of the decisionmaking process. Our analysis is based on aggregate data of all acts voted on by the Swiss Parliament since 1947 – those brought about by popular initiatives or those subject to optional and mandatory referendum – and on individual survey data on most federal votes held since 1981. We underline the high support of government and the impact of elite consensus on the destiny of legislative acts in the plebiscitary phase (submitted to a vote or not, subsequently accepted or not). While congruent with the aggregate analysis, results obtained at the individual level are less clearcut. The influence of voting recommendations and information channels on the voter's decision appears rather weak.     

Till Immigration do us Part? Public Opinion and the Dilemma between Immigration Control and Bilateral Agreements

As a result of the initiative against mass immigration (MEI) Switzerland faces a dilemma between control of immigration and the continuation of bilateral agreements. This contribution raises two questions: First, have Swiss citizens' perceptions regarding the incompatibility between immigration control and bilateral agreements evolved since the vote on the MEI in February 2014? Second, what would Swiss citizens decide if they had to choose between the implementation of the MEI and the continuation of the bilateral strategy? We ground our analysis on data from the VOX surveys regarding the MEI and the more recent vote of November 2014 (Ecopop initiative). While Swiss voters still seem to be uncertain about the issue of compatibility, they nevertheless show support for the continuation of the bilateral agreements. Our analyses highlight the importance of age, trust in government and left‐right orientation for individual opinions towards the bilateral way.