Testing human hair for cannabis

To validate information on cannabis use, we investigated human hair and pubic hair for cannabinoids (THC and THC-COOH) by gas chromatography/mass spectrometry. Samples (100 mg approximately) were decontaminated with methylene chloride, then pulverized and dissolved in 1 ml 1 N NaOH for 10 min at 95 °C in the presence of 200 ng of deuterated standards. After cooling, samples were extracted by n-hexane/ethyl acetate after acidification with acetic acid. After derivatization of the dry extract by PFPA/PFP-OH, the drugs were separated on a 30-m capillary column and detected using selected-ion monitoring (m/z 377 and 459 for THC and THC-COOH, respectively). Forty-three hair samples were obtained from fatal heroin overdose cases. Among them, 35% tested positive for cannabinoids. Hair concentrations ranged from 0.26 to 2.17 ng/mg (mean, 0.74 ng/mg) and 0.07 to 0.33 ng/mg (mean, 0.16 ng/mg) of THC and THC-COOH, respectively. As is generally the case for other drugs detected in hair, metabolite concentration was always lower when compared to the parent drug concentration. In pubic hair, THC concentrations ranged from 0.34 to 3.91 ng/mg (mean, 1.35 ng/mg) and THC-COOH concentrations from 0.07 to 0.83 ng/mg (mean, 0.28 ng/mg). In most cases, the highest cannabinoid concentration was found in pubic hair, suggesting that this sample may be the more suitable for cannabis testing.     

Simultaneous determination of pethidine (meperidine), phenoperidine, and norpethidine (normeperidine), their common metabolite, by gas chromatography with selective nitrogen detection

This article describes a selective gas chromatographic method for the resolution and quantification of phenoperidine and its two metabolites, pethidine (meperidine) and norpethidine (normeperidine). Drugs and SKF 525 A, the internal standard, are separated from plasma by solvent extraction under alkaline conditions. They are chromatographed on a 3% OV-17 Chromosorb Q glass column and detected with a nitrogen-phosphorous detector. Linearity is observed in the study range (5-200 ng/ml). No interference by endogenous substances is noted.     

Detection of drugs in human hair using Abbott ADx, with confirmation by gas chromatography/mass spectrometry (GC/MS).

The authors suggest use of the fluorescence polarization immunoassay (FPIA) technique in evaluation of chronic drug abuse using human hair. Hair was decontaminated in 5 mL of ethanol for 15 min at 37 degrees C and then incubated in 3 mL of 1M sodium hydroxide (NaOH) for 1 h at 100 degrees C. Afterwards, the aliquots were neutralized and analyzed using Abbott ADx for a negative or positive response for the following drugs: benzodiazepines, barbiturates, antidepressants, opiates, cocaine, amphetamine, and cannabis. All the positive samples were confirmed by gas chromatography/mass spectrometry (GC/MS). Only one false positive was detected (caused by interference of a phenothiazine with the antidepressants kit), clearly demonstrating the capability of ADx for toxicological screening of human hair.     

Detection of nandrolone metabolites in urine after a football game in professional and amateur players: a Bayesian comparison.

Nandrolone (19-nortestosterone) is a widely used anabolic steroid in sports where strength plays an essential role. Once nandrolone has been metabolised, two major metabolites are excreted in urine, 19-norandrosterone (NA) and 19-noretiocholanolone (NE). In 1997, in France, quite a few sportsmen had concentrations of 19-norandrosterone very close to the IOC cut off limit (2ng/ml). At that time, a debate took place about the capability of the human male body to produce by itself these metabolites without any intake of nandrolone or related compounds. The International Football Federation (FIFA) was very concerned with this problematic, especially because the World Cup was about to start in France. In this respect, a statistical study was held with all football players from the first and second divisions of the Swiss Football National League. All players gave a urine sample after effort and around 6% of them showed traces of 19-norandrosterone. These results were compared with amateur football players (control group) and around 6% of them had very small amounts of 19-norandrosterone and/or 19-noretiocholanolone in urine after effort, whereas none of them had detectable traces of one or the other metabolite before effort. The origin of these compounds in urine after a strenuous physical activity is still unknown, but three hypotheses can be put forward. First, an endogenous production of nandrolone metabolites takes place. Second, nandrolone metabolites are released from the fatty tissues after an intake of nandrolone, some related compounds or some contaminated nutritive supplements. Finally, the sportsmen may have taken something during or just before the football game.     

The French population censuses: Purposes and uses during the 17th, 18th and 19th centuries

From the mid-17th until the beginning of the 20th century, French censuses became increasingly more frequent and organized. This article focuses on the purposes of the first censuses (military), how the population was conceived of, and what variables were collected. The main characteristics of included individuals, the data considered important during each period, and the major categories chosen are examined. Also included are the evolution of reasons for knowing the precise age of individuals and how age groups were standardized because these aspects are closely linked to census operations. Finally, we will see how censuses have been used to obtain an overview of the population and, during the 19th century, how they were central to the discussion of the decline in fertility and, more generally, the changes occurring in the French population. How each new question led to the invention of a new variable and how data were presented is also examined.     

Reviews

THE ROOTS OF U.S. POLICY TOWARD LA TIN AMERICA

G. Pope Atkins, Latin America in the International Political System, second edition. (Boulder: Westview Press, 1989. Pp. 421.)

Lars Schoultz: National Security and United States Policy toward Latin America. (New Jersey: Princeton University Press, 1987. Pp. 377.)

Kevin J. Middlebrook and Carlos Rico, eds.: The United States and Latin America in the 1980s (Pittsburgh: University of Pittsburgh Press, 1986. Pp. 648. Second printing 1988.)

GENEROSITY AND SELF‐INTEREST

Teresa Odendahl: Charity Begins at Home: Generosity and Self‐interest among the Philanthropic Elite. (New York: Basic Books, 1990. Pp. 298.)

HOBBES AMONG THE PATRIARCHS

Arnold A. Rogow: Thomas Hobbes: Radical in the Service of Reaction. (New York: W. W. Norton Company, 1986. Pp. 287.)

STRACHEY AND MACLEAN: BRITISH ALTERNA TIVES

Michael Newman: John Strachey. (Manchester: Manchester Press, 1989. Pp. 201.)

B. J. Ripley and J. McHugh: John Maclean. (Manchester: Manchester University Press, 1989. Pp. 201.)     

From Adjudication to Aftermath: Assessing the ICTY’s Goals beyond Prosecution

After more than a dozen years of activity, some 161 indictments, 64 arrests, and 47 surrenders, the International Criminal Tribunal for the former Yugoslavia (ICTY) has accomplished a good deal in terms of its primary task of prosecution. Nonetheless, there is still much debate over the state of transitional justice in the Balkans and what has been accomplished. We cannot forget that the ICTY was created with broad political and social purposes in mind, specifically to contribute to the restoration and maintenance of peace. Using a comparative framework, we develop benchmarks of transitional justice outcomes to examine these vague but important and ambitious goals. Although conventional wisdom says that the ICTY is used instrumentally by Balkan leaders who are fundamentally opposed to the court??s existence, we demonstrate that there is also evidence of broader political and social change throughout the region. Thus, we contend that Balkan countries have indeed moved beyond mere prosecution.     

Intimate Partner Violence Victim and Perpetrator Characteristics Among Couples in the United States

This paper describes the characteristics (sociodemographic, drinking and selected psychological attributes) of victims, perpetrators and those who engage in mutual intimate partner violence (IPV) among couples in the U.S. Subjects constitute a multistage area probability sample representative of married and cohabiting couples from the 48 contiguous United States. Results indicate that age is the only variable that appears to have a consistent effect for men and women and across violence-related statuses: Older individuals are less likely to be victims, perpetrators and less likely to be involved in mutually violent relationships. Other variables such as ethnicity, marital status, drinking, impulsivity, depression and powerlessness are either gender or status-specific in their ability to predict victimization, perpetration or victimization/perpetration. Overall, those involved in violent relationships do not appear to be very different from those not involved in violent relationships. The most likely reason for lack of this difference is the nature of IPV in general population samples, which is in most cases moderate. Work on this paper was supported by a grant (R37-AA10908) from the National Institute on Alcohol Abuse and Alcoholism to the University of Texas School of Public Health.