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Darrell O. Ricke Ph.D. Philip Fremont‐Smith M.S. James Watkins B.S. Sara Stankiewicz M.S. Tara Boettcher B.S. Eric Schwoebel Ph.D. 《Journal of forensic sciences》2019,64(5):1468-1474
High‐throughput sequencing (HTS) of large panels of single nucleotide polymorphisms (SNPs) provides an alternative or complimentary approach to short tandem repeats (STRs) panels for the analysis of complex DNA mixture forensic samples. For STRs, methods to estimate individual contribution concentrations compare capillary electrophoresis peak heights, peak areas, or HTS allele read counts within a mixture. This article introduces three approaches (mean, median, and slope methods) for estimating individual DNA contributions to forensic mixtures for HTS/massively parallel sequencing (MPS) SNP panels. For SNPs, the major:minor allele ratios or counts, unique to each contributor, were compared to estimate contributor proportion within the mixture using the mean, median, and slope intercept for these alleles. The estimates for these three methods were typically within 5% of planned experimental contributions for defined mixtures. 相似文献
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In recent years controversy has arisen over whether the rate of women's gun ownership has increased over time. While media reports claimed a rising trend in women's gun ownership, existing scholarly studies found stable rates over time. This paper investigates the issue using the 1973–2002 General Social Survey data. Our bivariate analysis reveals a declining trend in female gun ownership, especially in recent years. The logistic regression results indicate that holding relevant variables constant, the probability of female gun ownership decreases over time. Comparisons are also made with men. Similar results for male gun ownership are obtained. Possible explanations and implications of findings are discussed. 相似文献
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Philip Longworth 《The Journal of peasant studies》2013,40(2):183-205
This paper examines the leadership of the Pugachev revolt, the vast peasant uprising which took place in Russia between 1773 and 1775. It is also concerned with certain general issues, particularly those concerning the raising and subsequent sustaining of large‐scale peasant movements in ‘pre‐industrial’ societies where peasant organisations beyond village level are lacking. The Pugachev revolt had peculiarities which are of intrinsic interest, but it also provides significant parallels and contrasts to other peasant uprisings (not only in seventeenth‐ and eighteenth‐century Russia) and generally serves to highlight the problems of the articulation of rural protest in backward societies. 相似文献
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Anderson L 《Time》2008,171(19):88-89
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Trade has again emerged as a controversial issue in America, yet we know little about the ideas that guide American thinking on these questions. By combining traditional survey methods with experimental manipulation of problem content, this study explores the ideational landscape among elite Americans and pays particular attention to how elite Americans combine their ideas about commerce with their ideas about national security and social justice. We find that most American leaders think like intuitive neoclassical economists and that only a minority think along intuitive neorealist or Rawlsian lines. Among the mass public, in contrast, a majority make judgments like intuitive neorealists and intuitive Rawlsians. Although elite respondents see international institutions as promising vehicles in principle, in practice they favor exploiting America's advantage in bilateral bargaining power over granting authority to the World Trade Organization. The distribution of these ideas in America is not arrayed neatly along traditional ideological divisions. To understand the ideational landscape, it is necessary to identify how distinctive mentaal models—mercantilist, neorealist, egalitarian, and neoclassical economic—sensitize or desensitize people to particular aspects of geopolitical problems, an approach we call cognitive interactionism. 相似文献