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Darrell O. Ricke Ph.D. Philip Fremont‐Smith M.S. James Watkins B.S. Sara Stankiewicz M.S. Tara Boettcher B.S. Eric Schwoebel Ph.D. 《Journal of forensic sciences》2019,64(5):1468-1474
High‐throughput sequencing (HTS) of large panels of single nucleotide polymorphisms (SNPs) provides an alternative or complimentary approach to short tandem repeats (STRs) panels for the analysis of complex DNA mixture forensic samples. For STRs, methods to estimate individual contribution concentrations compare capillary electrophoresis peak heights, peak areas, or HTS allele read counts within a mixture. This article introduces three approaches (mean, median, and slope methods) for estimating individual DNA contributions to forensic mixtures for HTS/massively parallel sequencing (MPS) SNP panels. For SNPs, the major:minor allele ratios or counts, unique to each contributor, were compared to estimate contributor proportion within the mixture using the mean, median, and slope intercept for these alleles. The estimates for these three methods were typically within 5% of planned experimental contributions for defined mixtures. 相似文献
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In recent years controversy has arisen over whether the rate of women's gun ownership has increased over time. While media reports claimed a rising trend in women's gun ownership, existing scholarly studies found stable rates over time. This paper investigates the issue using the 1973–2002 General Social Survey data. Our bivariate analysis reveals a declining trend in female gun ownership, especially in recent years. The logistic regression results indicate that holding relevant variables constant, the probability of female gun ownership decreases over time. Comparisons are also made with men. Similar results for male gun ownership are obtained. Possible explanations and implications of findings are discussed. 相似文献
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Philip Longworth 《The Journal of peasant studies》2013,40(2):183-205
This paper examines the leadership of the Pugachev revolt, the vast peasant uprising which took place in Russia between 1773 and 1775. It is also concerned with certain general issues, particularly those concerning the raising and subsequent sustaining of large‐scale peasant movements in ‘pre‐industrial’ societies where peasant organisations beyond village level are lacking. The Pugachev revolt had peculiarities which are of intrinsic interest, but it also provides significant parallels and contrasts to other peasant uprisings (not only in seventeenth‐ and eighteenth‐century Russia) and generally serves to highlight the problems of the articulation of rural protest in backward societies. 相似文献
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Jennifer E. Lansford Ley A. Killeya-Jones Shari Miller Philip R. Costanzo 《Journal of youth and adolescence》2009,38(8):1084-1095
Sociometric nominations, social cognitive maps, and self-report questionnaires were completed in consecutive years by 327
students (56% girls) followed longitudinally from grade 7 to grade 8 to examine the stability of social standing in peer groups
and correlates of changes in social standing. Social preference, perceived popularity, network centrality, and leadership
were moderately stable from grade 7 to grade 8. Alcohol use and relational aggression in grade 7 predicted changes in social
preference and centrality, respectively, between grade 7 and grade 8, but these effects were moderated by gender and ethnicity.
Changes in social standing from grade 7 to grade 8 were unrelated to grade 8 physical aggression, relational aggression, and
alcohol use after controlling for the grade 7 corollaries of these behaviors. Results are discussed in terms of their implications
for understanding links between social standing and problem behaviors during adolescence.
相似文献
Jennifer E. LansfordEmail: |
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Welton Chang Elissabeth Berdini David R. Mandel Philip E. Tetlock 《Intelligence & National Security》2018,33(3):337-356
Structured analytic techniques (SATs) are intended to improve intelligence analysis by checking the two canonical sources of error: systematic biases and random noise. Although both goals are achievable, no one knows how close the current generation of SATs comes to achieving either of them. We identify two root problems: (1) SATs treat bipolar biases as unipolar. As a result, we lack metrics for gauging possible over-shooting—and have no way of knowing when SATs that focus on suppressing one bias (e.g., over-confidence) are triggering the opposing bias (e.g., under-confidence); (2) SATs tacitly assume that problem decomposition (e.g., breaking reasoning into rows and columns of matrices corresponding to hypotheses and evidence) is a sound means of reducing noise in assessments. But no one has ever actually tested whether decomposition is adding or subtracting noise from the analytic process—and there are good reasons for suspecting that decomposition will, on balance, degrade the reliability of analytic judgment. The central shortcoming is that SATs have not been subject to sustained scientific of the sort that could reveal when they are helping or harming the cause of delivering accurate assessments of the world to the policy community. 相似文献