Acute fatal acetaminophen overdose without liver necrosis

Two unusual cases of suicidal overdose of acetaminophen (paracetamol) without the usual extensive centrilobular necrosis of the liver are reported. Both cases were subjected to comprehensive drug screening by immunoassay, and a combination of gas chromatography with mass spectrometry, nitrogen detection, and electron capture detection. Acetaminophen was detected in both cases. No other drugs were detected in case #1, and only a small amount of olanzapine (<0.1 mg/L) was detected in case #2. No anatomical cause of death was identified in either case. If untreated, the normal outcome of a large acetaminophen overdose would be massive hepatic necrosis with delayed death and low blood and tissue acetaminophen concentrations. In contrast, particularly high postmortem acetaminophen concentrations were measured in both our cases with little hepatic tissue damage. For case #1, femoral blood acetaminophen 1280 mg/L, vitreous 878 mg/L, and liver 729 mg/kg; in case #2, cardiac blood 1220 mg/L, vitreous 779 mg/L, liver 3260 mg/kg, and gastric 11,500 mg/500 g. Acetaminophen was measured using high performance liquid chromatography with UV detection (254 nm) using 3-hydroxyacetanilide as the internal standard. The very high concentrations of acetaminophen is these cases but relatively little hepatic damage suggests an alternative, possibly cardiac, mechanism of death.     

Aspects of Legislative Drafting: Some South African Realities (or Plain Language Is Not Always Plain Sailing)

It seems to me that a sort of hieratic language has developedby which the priests incant the commandments. I seem to seethe ordinary citizen today standing before the law like thelaity in a medieval church: at the far end the lights glow,the priestly figures move to and fro, but it is in an unknowntongue that the great mysteries of right and wrong are proclaimed.¹     

The Social Value of Expressing Personal and General Belief in a Just World in Different Contexts

Research conducted in France and Portugal has consistently found that expressing high versus low Belief in a Personal Just World (BJW-P) is more socially valued. Results concerning the Belief in a General Just World (BJW-G) have been mixed. We propose this reflects a higher resistance of BJW-P social value to contextual changes. Testing this idea was the main goal of three experimental studies conducted in France, Germany and Portugal. In Study 1 (N = 283) participants expressed higher BJW-G when asked to convey a positive versus a negative image in a job application at a bank. The opposite pattern showed up when they applied for a job at a Human Rights NGO, an employment assistance institution and a trade union. Participants expressed higher BJW-P in all contexts, except at the trade union (no significant differences). In Study 2 (N = 489) participants judged bogus candidates who expressed high or low BJW-P/G while applying for a job at the same contexts. The patterns of judgments replicated those of self-presentations in Study 1. In Study 3 (N = 158), participants were asked to judge targets who expressed high versus moderate versus low BJW-P at a trade union. The former target was more socially valued than the other two. High versus low BJW-P expression was associated with higher stamina and less unadjusted self-enhancement. We conclude that in Western societies the expression of BJW-P is more central to the legitimation of the status quo and that of BJW-G is more context sensitive.     

The merits of Neo-Downsian modeling of the alternative vote: A reply to Horowitz

In Professor Horowitz’s rejoinders (2004, 2006) to Fraenkel and Grofman (2004, 2006a), he mischaracterizes our formal results, retreats from previous claims about the conditions for the alternative vote electoral system to generate centripetal outcomes, renders explicit his dubious assumptions about voter behavior in divided societies, and greatly exaggerates the global evidence in support of pro-moderation outcomes under the alternative vote. Here we respond to Horowitz's (2004), criticism in this journal of the formal model of Fraenkel and Grofman (2004) and to the broader defense in Horowitz (2006) of majoritarian vote pooling arrangements as means of mitigating ethnic conflict in deeply divided societies.     

Personality and repeated suicide attempts in dependent adolescents and young adults

This study compared personality characteristics of subjects with dependence disorders who had previously made a suicide attempt. The population, recruited in France, Belgium, and Switzerland, was composed of 570 subjects (225 females, 345 males, mean age = 27.3, SD = 8.5). The subjects' psychological dimensions were investigated by means of several self-report questionnaires including: BDI-13 (Beck), Sensation-Seeking Scale (Zuckerman), Toronto Alexithymia Scale (Taylor), Interpersonal Dependency Inventory (Hirschfeld), MMPI-2, and some additional scales. For most dimensions, repeat attempters, both past and recent, but more specifically the recent repeaters, had a more severe psychological profile compared to the other suicide attempters.