Forensic STRs as potential disease markers: A study of VWA and von Willebrand's Disease

In recent years it has been established that non-coding variants may be in linkage disequilibrium (LD) with coding variants up to several thousand base pairs away forming haplotype blocks. These non-coding markers may be haplotype specific and, therefore, informative regarding the surrounding coding sequence. In this study, we chose to study the VWA short tandem repeat (STR) as it is targeted in all major commercial kits utilized in routine forensic DNA profiling and is located in the von Willebrand Factor (vWF) gene; a gene associated with von Willebrand's Disease (vWD). We examined the VWA STR together with single nucleotide polymorphisms (SNPs) located throughout the vWF gene to identify haplotype structures and the extent of LD between markers in the region. Several areas exhibiting LD were identified by population data analysis in the 178 kilobase (178kb) vWF gene, which was supported by family studies. However, there appeared to be no evidence of LD blocks surrounding the VWA STR and evidence for recombination within 3 kb of VWA, hence, it is unlikely that VWA STR alleles could be used to predict haplotypes within the vWF gene that are associated with different forms of vWD.     

Protecting the Right to Housing in the Aftermath of Natural Disaster: Standards in International Human Rights Law

In 2006, the United Nations High Commissioner for Refugees reportedthat an average of 211 million people each year were directlyaffected by the accumulated impact of natural disasters.¹ Thisis approximately five times the number of people thought tohave been affected by conflict over the past decade.² It iscommonly expected that, as a result of climate change, populationgrowth and inappropriate urbanisation, the incidence, severityand impact of natural disasters will continue to rise. And yetwhile the obligations of states in situations of armed conflicthave been extensively debated, the applicability of human rightslaw in the aftermath of natural disaster has not been so widelyexamined by regional or international human rights bodies. Thispaper considers the obligations of governments in the aftermathof natural disasters, with a particular focus on the right tohousing. The applicability of human rights law (and specificallyeconomic, social and cultural rights) in the aftermath of naturaldisaster is considered in a general sense, followed by a discussionof the content of the right to housing, and the obligationsof governments to respect, protect and fulfil this right inthe course of responding to disaster. The question of whetherstates have an obligation to provide restitution, compensationor other form of reparation to those who have lost homes, landand property by reason of natural disaster is also discussed.The paper draws on examples from the Indian Ocean tsunami (2004),the Pakistan earthquake (2005) and the South Asian floods (2007),and identifies specific elements of government obligations thatare of particular importance in ensuring the right to adequatehousing in the aftermath of natural disaster.     

Managing Mass Fatalities during COVID-19: Lessons for Promoting Community Resilience during Global Pandemics

In the United States and around the world, COVID-19 represents a mass fatality incident, as there are more bodies than can be handled using existing resources. Although the management and disposition of bodies is distressing and heartrending, it is a task that local, state, and federal governments must plan for and respond to collaboratively with the private sector and faith-based community. When mass fatalities are mismanaged, there are grave emotional and mental health consequences that can delay recovery and undermine community resilience. Using insights from one author's mass fatality management research during the 2010 Haiti earthquake, this Viewpoint essay explores how mass fatalities are being managed in response to COVID-19. Based on the researcher's findings a decade ago, it is apparent that many lessons have not been learned. The essay concludes by providing governments with practical lessons on how to manage mass fatalities to facilitate and promote community resilience.     

A Conversation with Tibetans? Reconsidering the Relationship between Religious Beliefs and Secular Legal Discourse

Over cups of chai, a conversation between U.S. law professors and Tibetan exiles about the formation of a new democratic Tibetan government under the Dalai Lama goes awry. This article investigates why the misunderstandings occurred by presenting the context of the Tibetan and U. S. concepts of sacredness and secularity. The former Tibetan government and legal system are explained in some derail as well as the Tibetan wiew of the sacred and secular spheres in society. The deistic origins of the U.S. Constitution and the pervasive religious cosmology of the Framers are then described. These two similar positions are contrasted with the current modern and postmodern positions of an all-encompassing secular sphere that defines and contains religion. The author argues that "sacred" and "secular" have changed positions, with secularity now having an unmarked positive value and being viewed by U.S. law professors as a necessity for a democratic political and legal system. As the conversation with the Tibetans demonstrates, the richness and power of an integrated sacred perspective is difficult to comprehend from a hegemonic secular public space. Reformulating this "inarticulate debate" will be necessary for a coherent conversation to take place.     

Regulating Marriage and Cohabitation: Changing Family Values and Policies in Europe and North America—An Introductory Critique

The inspiration for this special issue came from our observation that the British and American approaches to family policy in general, and to marriage and cohabitation in particular, set them apart from their closest neighbors in Europe and North America, respectively. While certain demographic trends can be observed across the Western world, the response of Britain and the United States to such trends differs significantly from that of other jurisdictions in terms of family policy.     

The stigma of public programs: Does a separate S‐CHIP program reduce it?

Previous studies suggest access to and satisfaction with care may be different for enrollees in S-CHIP and Medicaid, but it is unclear whether those differences are fully explained by socioeconomic characteristics of the enrollees. We analyze access and satisfaction of three groups of children: Medicaid enrolled, S-CHIP enrolled, and children who are income eligible for Medicaid but carry a card similar to the state's S-CHIP children's card. Both enrollees and providers may believe that these children are enrolled in S-CHIP despite the fact that reimbursement is through the state's Medicaid system. Results indicate that the same network of providers treat, or are perceived by families to treat, the three groups differently. They support the notion that some of the differences in satisfaction between S-CHIP and Medicaid enrollees are related to unmeasured characteristics (for example, income) of the families in the different programs, but that programmatic identity contributes substantially to differential care experience.     

Presidential address: How to improve poverty measurement in the United States

This paper discusses the reasons why the current official U.S. poverty measure is outdated and nonresponsive to many anti‐poverty initiatives. A variety of efforts to update and improve the statistic have failed, for political, technical, and institutional reasons. Meanwhile, the European Union is taking a very different approach to poverty measurement. The paper ends with four recommended steps that would allow the U.S. to improve its measurement of poverty and economic need.     

Lawyers' Pro Bono Service and American-Style Civil Legal Assistance

Lawyers are often criticized for stinting on their responsibilities for public service; nevertheless, their uncompensated provision of legal services to poor people, or pro bono work, provides a substantial part of available civil legal assistance in the United States. Cross-sectional analysis of data from the late 1990s reveals that reliance on pro bono may render assistance vulnerable to market pressures in ways both obvious and subtle. In states where the legal profession takes in more receipts per lawyer, larger proportions of the profession provide uncompensated service to the poor. In states where the profession feels its work jurisdiction is under threat from unauthorized practice by other occupations, larger proportions of the profession participate in pro bono work than in states where there is no concern about unauthorized practice. As federally subsidized legal assistance shrinks in both scope and scale, growing reliance on pro bono leaves American-style civil legal assistance increasingly vulnerable to market forces.