Hepatic abscess formation and unexpected death: a delayed complication of occult intraabdominal foreign body.

A case of unexpected death in a 65-year-old woman, caused by a migrating foreign body that resulted in multifocal hepatic abscesses, is reported. The foreign body was subsequently identified as a portion of chicken fibula. The prolonged time course of the illness, with relatively nonspecific symptoms and signs, resulted in establishment of the diagnosis only at autopsy.     

Septo-optic dysplasia and unexpected adult death--an autopsy approach.

A 20-year-old woman who suffered from septo-optic dysplasia died unexpectedly following a presumed viral gastroenteritis. Autopsy and neuropathological examination confirmed optic nerve hypoplasia with absence of the septum pellucidum. Marked adrenal gland hypoplasia reflected hypothalamic hypopituitarism. The small and large intestines were dilated and filled with liquid fecal material. This case demonstrates that individuals with septo-optic dysplasia may be at risk of unexpected death at all ages. The complexity of mechanisms of death in rare dysmorphic conditions may be overlooked if relevant clinical information is not available at the time of autopsy and unless specific steps are taken to clearly delineate the underlying features of the condition.     

Short notes on some books received

Africa's Management in the 1990s and Beyond: Reconciling Indigenous and Transplanted Institutions. By Mamadou Dia. Washington, DC: The World Bank, 1996. Pp.xii + 293. NP. ISBN 0 8213 3431 X

A Land Without Gods: Process Theory, Maldevelopment and the Mexican Nahuas. By Jacques M. Chevalier and Daniel Buckles. London: Zed Books, 1995. Pp.x + 374. £55.00/$69.95 and £19.95/$29.95. ISBN 1 85649 325 3 and 326 1

Local Resource Management in Africa. Edited by J.P.M. van den Breemer, C.A. Drijver and L.B. Venema. Chichester: John Wiley, 1995. Pp.xii + 245. £40. ISBN 0 47196004 7

Third World Cities in Global Perspective: The Political Economy of Uneven Urbanization. By David A. Smith. Boulder, CO: Westview Press, 1996. Pp.xiii + 202. £40.95 and £13.50. ISBN 0 8133 8720 5 and 2998 1

Power of Development. Edited by Jonathon Crush. London and New York: Routledge, 1995. Pp.xvi + 324. £35 and £ 14.99. ISBN 0 415 11176 5 and 11177 3

Financial Liberalisation and Investment. By K.L. Gupta and R. Lensink. London: Routledge, 1996. Pp.xii + 183. £40. ISBN 0 415 13879 5

Anthropology of Tourism. By Denison Nash. Oxford, New York and Tokyo: Pergamon, 1996. Pp.ix + 205. £41/US$66. ISBN 0 0804 42398 1

Politics of Technology in Latin America. Edited by Maria Ines Bastos and Charles Cooper. London and New York: Routledge, 1995. Pp.xii + 258. £47.50. ISBN 0 415 12690

Voices from Mutira: Change in the Lives of Rural Gikuyu Women: 1910–1995. By Jean Davison. Boulder, CO and London: Lynne Reinner Publisher, 1996. Pp.vi + 271. £18.95. ISBN 1 55587 602 1

Women and Politics in the Third World. Edited by Haleh Afshar London: Croom Helm, 1996. Pp.xi + 210. £40 and £12.99. ISBN 0 415 13853 1 and 13861

Re‐Presenting the City: Ethnicity, Capital and Culture in the Twenty‐First Century Metropolis. Edited by Anthony D. King. Basingstoke: Macmillan, 1996. Pp.ix + 282. £42.50 and £13.99. ISBN 0 333 60191 2 and 60192 0

Women and Industrialization in Asia Edited by Susan Horton, London and New York: Routledge, 1996. £50. ISBN 0415 12907 9

Enterprise and the State in Korea and Taiwan. By Karl J. Fields. Ithaca, NY and London: Cornell University Press, 1995. Pp.xiv + 269. NP. ISBN 0 8014 3009 7     

Simultaneous analysis of six amphetamines and analogues in hair, blood and urine by LC-ESI-MS/MS. Application to the determination of MDMA after low ecstasy intake

A rapid and sensitive method using LC-MS/MS triple stage quadrupole for the determination of traces of amphetamine (AP), methamphetamine (MA), 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"), 3,4-methylenedioxyethamphetamine (MDEA), and N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB) in hair, blood and urine has been developed and validated. Chromatography was carried out on an Uptisphere ODB C(18) 5 microm, 2.1 mm x 150 mm column (Interchim, France) with a gradient of acetonitrile and formate 2 mM pH 3.0 buffer. Urine and blood were extracted with Toxitube A (Varian, France). Segmented scalp hair was treated by incubation 15 min at 80 degrees C in NaOH 1M before liquid-liquid extraction with hexane/ethyl acetate (2/1, v/v). The limits of quantification (LOQ) in blood and urine were at 0.1 ng/mL for all analytes. In hair, LOQ was <5 pg/mg for MA, MDMA, MDEA and MBDB, at 14.7 pg/mg for AP and 15.7 pg/mg for MDA. Calibration curves were linear in the range 0.1-50 ng/mL in blood and urine; in the range 5-500 pg/mg for MA, MDMA, MDEA and MBDB, and 20-500 pg/mg for AP and MDA. Inter-day precisions were <13% for all analytes in all matrices. Accuracy was <20% in blood and urine at 1 and 50 ng/mL and <10% in hair at 20 and 250 pg/mg. This method was applied to the determination of MDMA in a forensic case of single administration of ecstasy to a 16-year-old female without her knowledge during a party. She suffered from hyperactivity, sweating and agitation. A first sample of urine was collected a few hours after (T+12h) and tested positive to amphetamines by immunoassay by a clinical laboratory. Blood and urine were sampled for forensic purposes at day 8 (D+8) and scalp hair at day 60 (D+60). No MDMA was detected in blood, but urine and hair were tested positive, respectively at 0.42 ng/mL and at 22 pg/mg in hair only in the segment corresponding to the period of the offence, while no MDA was detectable. This method allows the detection of MDMA up to 8 days in urine after single intake.