Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial

Early interventions are a preferred method for addressing behavioral problems in high‐risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve efficiency. One potential source of such variation is the genome. We conducted a genetic analysis of the Fast Track randomized control trial, a 10‐year‐long intervention to prevent high‐risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior. We tested whether variants of the glucocorticoid receptor gene NR3C1 were associated with differences in response to the Fast Track intervention. We found that in European‐American children, a variant of NR3C1 identified by the single‐nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in control group children and decreased risk for externalizing psychopathology in intervention group children. Variation in NR3C1 measured in this study was not associated with differential intervention response in African‐American children. We discuss implications for efforts to prevent externalizing problems in high‐risk children and for public policy in the genomic era.     

Anti-social behaviour: children,schools and parents

Under Prime Minister Tony Blair's New Labour government, increased criminalisation of previously non-criminal behaviour, anti-social behaviour and greater accountability of children and parents for their behaviour were evident. The article provides an overview of anti-social behaviour legislation and the implications for children, schools and parents. It focuses upon the interconnectedness of families and schools with the intention to better inform educational leaders of the changes to roles and responsibilities under the legislation.     

Location Efficiency and Mortgage Risks for Low-Income Households

Abstract

Household energy expenditures, especially for transportation, are fairly inelastic. Their effects on low-income households may be significant, due to the potential for energy consumption to displace other types of consumption when energy prices rise. Using accessibility as a proxy for lower transportation costs, we test the hypothesis that low- and moderate-income residents are less likely default when they are located in more accessible places. We find that regional accessibility has almost no effect on risks of default, but local job diversity has moderate mitigating effect.     

A Comparison of Defendants with Mental Illness Represented by Public Defenders and Private Attorneys: an Analysis of Court-Ordered Pretrial Psychiatric Evaluations

This study compared the characteristics and court-ordered evaluation questions and responses among 4,430 defendants to determine if differences existed between those represented by public defenders and private attorneys when receiving trial competency or responsibility psychiatric evaluations from a state department of mental health. Defendants represented by public defenders were more likely to be younger, to have less education, to have psychotic disorders, to have a history of inpatient psychiatric treatment, to live in urban or rural counties, and to be jailed at the time of the evaluation. In addition, defendants represented by public defenders were less likely to have a request for a criminal responsibility evaluation and more likely to be evaluated as having a mental illness, to be incompetent to stand trial, and to need hospitalization pending trial. Consideration of whether defendants with public defenders receiving less requests for responsibility evaluations was indicative of a therapeutic jurisprudence approach is discussed. Implications for research on types of legal representation of defendants with mental illness are discussed.     

‘The Message Is in the Book’: What Virago's Sale in 1995 Means for Feminist Publishing

This article examines the UK publisher Virago, the world's largest women's imprint and the best known of the second-wave feminist publishing houses that sprang up during the 1970s and 1980s. Feminist publishing remains a peculiarly unacknowledged and underexamined aspect of feminist history, but one that had real influence and effect. This article gives a historical account of Virago, noting its intention to enact feminist politicking through the act of publishing books. The author looks at the effect Virago had on the industry more widely, on literary culture and on attitudes to women. The author also examines changing formulations of feminism and how these were reflected—or not—through Virago's published output. The author then moves on to her central proposition: that Virago's sale in 1995, rather than marking the death of feminist publishing (as was stated in media comment at the time), was in fact the point at which it was saved. Virago's move into Little, Brown, coinciding with the rise of an increasingly commodified consumer culture, the conglomeration of the book industry and more pluralized expressions of feminism, allowed it to continue to work as a publisher of women's writing while none of its contemporaries survived. The author looks in detail at the changes post-1995 within the book industry, within feminism and in wider culture, as well as at Virago. The author asks whether Virago still has value as a ‘feminist’ imprint and how it has sought to remain vital and relevant.     

Overlooking the front line: Impacts of front-line worker inclusion on implementation and outcomes of collaborative innovation

Policymakers acknowledge the need to drive innovation in health and social care, given the complex, “wicked” problems that such services are tasked with solving and the concept of collaborative innovation is proposed as a tool in which to reach solutions to these problems. Prior case studies have overlooked the element of front-line worker inclusion on processes of collaborative innovation. This research explores this element through a case study of an intermediate care facility in Scotland. This collaboration produced innovation, but the strength of the innovative solution was diluted by the omission of front-line workers in key phases of the innovation process. This paper contributes to the broader public administration literature by operationalizing a novel conceptual framework of collaborative innovation and by exploring the problematic implications of neglecting to include front line worker perspectives throughout the process of collaborative innovation.     

Bank regulatory authority in China

In China the regulation of credit and capital is conducted by the banking system. Originally this system was highly centralized under the direct control the Ministry of Finance. More recently, as the Ministry of Finance has become busier with additional responsibilities such as the management of an increasingly complex tax system, and the banking system has gained its independence.

For the banks, this reorganization not only represents an increase in authority and status, it also makes possible an increased effectiveness in carrying out existing regulatory responsibilities. The need for increased effectiveness becomes evident on review of the role that the banks have played in Chinese society prior to the 1985 reforms. Without the means to enforce their authority, the banks could not be as influential in regulating the economy as had been intended.

Because they have been provided with enforcement regulations, the banks can now influence not only the provision of credit and currency but also the management of group and individual businesses and organizations throughout China. As the communist party stepping back from law and policy enforcement, the banks are partially filling the vacuum.