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41.
The Y-chromosome haplogroup composition of the population of São Tomé e Príncipe and Cabo Verde Archipelagos was profiled by using 24 biallelic markers, and compared with populations from Europe, Africa and the Middle East. According to the traditional view, these archipelagos colonized by the Portuguese in the 15th century were settled mainly by West African slaves, with the addition of a minor fraction of male colonizers from Europe. Although the major proportion of the founding population of São Tomé e Príncipe cluster in haplogroup E3a (84.2%), very common among sub-Saharans, this lineage was observed at a frequency of only 15.9% in Cabo Verde. Haplogroups I, J and R1, characterized of populations of Europe and the Middle East account for more than half of the paternal lineages of Cabo Verdeans (53.5%). These West Eurasian haplogroups are found at a frequency of only 12.5% in the population of São Tomé e Príncipe. Our findings suggest that despite the sub-Saharan genetic background of these archipelagos, a relevant contribution of European paternal lineages is present in nowadays populations indicating that gene flow from multiple sources have been important in the formation of the diversity of the islanders, nevertheless with a different degree of admixture.  相似文献   
42.
2,5-Dimethoxy-4-bromoamphetamine (DOB) is one of the potent hallucinogenic phenylalkylamines, whose ingestion has already caused several deaths reported all over the world. However, there is unsufficient information on DOB properties based on controlled pharmacokinetic studies available. The aim of this study was to clarify the distribution profile of DOB and its phenolic metabolite 2-methoxy-5-hydroxy-4-bromoamphetamine (2M5H4BA) in blood and biological tissues of experimental rats. The rats were administered a 20 mg/kg dose of DOB·HCl by oral ingestion or subcutaneous injection. Plasma and brain, liver and lung tissues were collected at 0.5, 1, 2, 4, 8, 16, and 32 h after dosing (three animals per time point). The samples were prepared by a liquid–liquid extraction procedure and the extracts were assayed by GC–MS. After per oral application, DOB peak plasma level of 320 ng/mL was reached after one-hour post dosing as well as 2M5H4BA peak concentration of 203 ng/mL. A rapid phase of DOB absorption, 2M5H4BA formation and their tissue distribution during the first two hours after application were followed by a slow decrease rate of the elimination process until 32 h. After subcutaneous application, high plasma levels of the unchanged parent drug and relatively reduced formation of its metabolite 2M5H4BA were observed. DOB maximum plasma concentration of 1143 ng/mL was reached after one-hour post application, whereas its metabolite peak level after 8 h was 213 ng/mL. The concentration profiles of both compounds in plasma after per oral and subcutaneous administration revealed the existence of significant first pass effect after per oral administration that significantly affected DOB bioavailability. DOB tissue concentrations exceeded plasma and the highest values were found in the lungs, where drug accumulation occurred with prolonged retention till 32 h after subcutaneous dose. Although the plasma/tissue transfer was more effective for the lipophilic parent drug than for its hydroxylated metabolite 2M5H4BA, the metabolite tissue levels were significant. The hallucinogenic potential of 2M5H4BA appearing in brain remains unclear as nothing is known about its pharmacological activity at present.  相似文献   
43.
Wiebke Marie Junk 《管理》2019,32(2):313-330
Lobbying access to policy discussions determines how political interests are voiced and potentially exert influence. This article addresses whether access to the national legislature and the media favors umbrella organizations, which represent interests of their member groups. It theorizes that the role of umbrellas goes beyond signaling a large individual membership or constituency of people, but that umbrellas are distinct in transmitting interests from other organizations. This function is expected to be valuable in exchanges with legislators who seek efficiency, input legitimacy, and policy implementation, but less valuable in the media arena. Using a new data set on lobbying by 286 groups on 12 issues in the United Kingdom and Germany, the article serves support for this theory: Umbrellas enjoy higher legislative access, but lower media access than groups without member organizations, irrespective of their individual membership or claimed constituency. The findings have implications for how we understand and study political representation.  相似文献   
44.
The rhetoric of then U.S. President‐elect Donald Trump and Philippines' President Rodrigo Duterte had triggered a shift in global political discourse (Greene, 2016 ). This study examines their responses on three similar crises: disrespectful remarks towards women, associations with controversial political figures, and remarks threatening geopolitical relations. Data from prestige publications, Washington Post (U.S.) and the Philippine Daily Inquirer, were analyzed during the acute stage of each crisis. Findings showed that both men employed confusing strategy combinations in their crisis responses. Despite incoherent application and contradictory strategies, they survived threats to their image as evidenced by poll results. New strategies (diversion and logorrhea) and a strategy amplifier (machismo) were uncovered. These strategies tapped on ambiguity and were found to be successfully employed in a post‐truth landscape. This study builds on Benoit's ( 2006 ) argument that “any attempt by a president to repair a damaged image … clearly merits scholarly attention” (p. 138).  相似文献   
45.
Book reviews     
One World to Share: selected speeches of the Commonwealth Secretary‐General, 1975–9. Shridath Ramphal, London: Hutchinson Benham. 1979. 444 pp. £10.95

The White House Years. Henry Kissinger, London: Weidenfeld and Nicolson &; Michael Joseph. 1979. 1545 pp. £14.95

Kissinger and the Meaning of History. Peter W Dickson, Cambridge University Press. 1978. 207 pp. £8.95

Beyond Kissinger: ways of conservative statecraft. George Liska, London: Johns Hopkins University Press. 1975. 169 pp. $2.95

Where the Grass is Greener. David M Smith, Harmondsworth, England: Penguin. 1979. 386 pp. £2.25

Small‐Scale Irrigation. Peter Stern, London: Intermediate Technology Publications. 1979. 152 pp. np

The Social and Ecological Effects of Water Development in Developing Countries. Edited by Carl Widstrand, Oxford: Pergamon. 1978. 120 pp. £10.00

Water in a Developing World: the management of a critical resource. Edited by Albert E Utton &; Ludwik Teclaff, Boulder, Colorado: Westview Press (distributed in the UK by Ernest Benn). 1978. 282 pp. £13.75

Marx and the End of Orientalism. Bryan S Turner, London: George Allen &; Unwin. 1978. 98 pp. £3.50

Project Planning for Developing Economies. WW Shaner, New York: Praeger. 1979. 235 pp. £14.25

International Development Administration: implementation analysis for development. Edited by G Honadle &; Rudi Klaus, New York: Praeger. 1979. 221 pp. £13.00

Nutrition and National Policy. Edited by Beverly Winikoff, London: MIT Press. 1979. 580pp. £15.75

The Nuclear Question: the United States and nuclear weapons, 1946–76. Michael Mandelbaum, Cambridge University Press. 1979.277 pp £12.50

Force Without War: US armed forces as political instruments. Barry M Blechman &; Stephen S Kaplan, Washington DC: Brookings Institution (distributed in the UK by Blackwells). 1978. 584 pp. £15.00. £6.50 pb

Nuclear Arms in the Third World: US policy dilemma. Ernest W Lefever, Washington DC: Brookings Institution (distributed in the UK by Blackwells). 1979. 154 pp. £8.50. £3.25 pb

The Nonaligned Movement: the origins of a Third World alliance. Peter Willetts, London: Frances Pinter. 1978.310 pp. £12.50

Coups and Earthquakes: reporting the world for America. Mort Rosenblum, New York: Harper &; Row. 1979. 230 pp. £5.95

Nations and States. Hugh Seton‐Watson, London: Methuen. 1979.563 pp. £12.00

Rich World, Poor World. Geoffrey Lean, London: George Allen &; Unwin. 1978.335pp. £4.50 pb

Your Own Pigs You May Not Eat: a comparative study of New Guinea societies. Paula G Rubel and Abraham Rosman University of Chicago Press. 1978.368pp. £14.40

Afterthoughts on Material Civilisation and Capitalism. Fernand Braudel, Baltimore: Johns Hopkins University Press. 1977.120 pp. $7.95

Women in the Muslim World. Edited by Lois Beck &; Nikki Keddie, Harvard University Press. 1979. 698 pp. £18.00

The Economics of Multinational Enterprise. Neil Hood &; Stephen Young, London: Longman Group. 1979. 412 pp. £7.95 pb

The Social and Cultural Impacts of Transnational Enterprises. Krishna Kumar, University of Sydney. Transnational Corporations Research Project (Working Paper No 6). 1979. 183 pp.

A New Stage in International Relations. N I Lebedev, Oxford: Pergamon. 1978. 253 pp. $20.00

The Political and Military Laws of War. J Lider, Farnborough, England: Saxon House. 1979. 266 pp. £10.50.

Becoming Modern. Alex Inkeles &; David H Smith, London: Heinemann Educational. 1974.436 pp. £5.00

The Capitalist World Economy. Immanuel Wallerstein, New York: Cambridge University Press. 1979. 305pp. £15.00

South Africa: the method in the madness. John Kane‐Berman, London: Pluto Press. 1979. 265 pp. £2.95 pb

White Man, We Want to Talk to You. Denis Herbstein, London: Andre Deutsch. 1979. 270 pp. £4.95

Africa Undermined: a history of the mining companies and the underdevelopment of Africa. G Lanning with M Mueller, Harmondsworth, England: Penguin. 1979. 590 pp. £3.50

Africanisation, Nationalisation and Inequality: mining labour and the copper belt in Zambian development. Philip Daniel, Cambridge University Press: 1979.202 pp. £12.50. £5.95 pb

Nasser and His Generation. PJ Vatikiotis, London: Croom Helm. 1978. 375 pp. £11.95

Politics Mainly Indian. W H Morris‐Jones, Bombay: Orient Longman. 1978. 392 pp. Rs 60.00

Papua New Guinea: its economic situation and prospects for development. G W Baldwin et al, London: Johns Hopkins University Press. 1978.223 pp. £4.50 pb

Paradise Postponed: essays on research and development in the South Pacific. Edited by Alexander Mamak &; Grant McCall, Oxford: Pergamon. 1978. 277 pp. £11.25

Urbanisation in Papua New Guinea: a study of ambivalent townsmen. Hal B Levine &; Marlene Wolfzahn Levine, Cambridge University Press. 1979.161 pp. £8.95. £3.95 pb

The Land of Promise: A critique of political Zionism. Abdelwahab M Elmessiri, New Brunswick, New Jersey: North American. 1977.255 pp. $6.95 pb

ASEAN Economies in Perspective: a comparative study of Indonesia, Malaysia, the Philippines, Singapore and Thailand. John Wong, London: Macmillan. 1979.217 pp. £3.95 pb

China's Role in World Affairs. Michael B Yahuda, London: Croom Helm. 1978. 300 pp. £10.95. £4.95 pb

Mao's China: a history of the People's Republic. Maurice Meisner, New York: Free Press. 1977. 416 pp. np

China and the Major Powers in East Asia. A Doak Barnett, Washington, DC: Brookings Institution (distributed in the UK by Blackwells). 1977. 416 pp. np

Chinese Politics After Mao. Edited by Jurgen Domes, Cardiff, Wales: University College Cardiff Press. 1979. 291 pp. np

São Paolo: growth and poverty. A Report from the São Paolo Peace and Justice Commission, with an introduction by Cardinal Arns, Archbishop of Säo Paulo. London: The Bowerdean Press (in association with The Catholic Institute for International Relations). 1978.128 pp. £3.40

Frontier Development Policy in Brazil: a study of Amazônia. Dennis J Mahar, New York: Praeger. 1979.182 pp. £10.50

Arise Ye Starvelings: the Jamaican labour rebellion of 1938 and its aftermath. Ken Post, London: Institute of Social Studies/The Hague: Martinus Nijhoff. 1979.502 pp. np

The Future of the Inter‐American System. Edited by TJ Farer, London: Praeger. 1979. 290 pp. £13.00  相似文献   
46.
The authors previously explored invention licensing from the university's perspective. In this paper we focus on the process from the perspective of firms activity engaged in licensing technology. A survey of industry licensing professionals addresses why some firms license technologies from universities and why others do not. The paper then considers the stage of development of university technologies, the characteristics of their licensing contracts, and sources of information about university technologies, all to better understand how the process works and what advantages and disadvantages it offers to all participants.  相似文献   
47.
48.
The residential aged care industry in Australia will expand rapidly over the next 10 years leading to substantial increases in government expenditure. Recent and future reforms are likely leading to changes in the structure of the industry with a potential impact on quality of care. The purpose of this paper is to stimulate broader public debate, based on the available evidence, about the preferred structure of this important industry. It examines the literature on the impact structure has on the quality of services and compares this with a fresh analysis of current trends. The paper argues that future policy should be evidence based and explicit about the structure of the industry that will emerge from current policy reforms.  相似文献   
49.
Correctional staff job burnout is costly to all involved. As such, it has generated a growing body of research. This study reviewed 53 empirical studies of correctional staff burnout and two review articles published between 1981 and 2014. The majority of studies focused on staff working in a variety of institutional positions, fewer studies focused exclusively on the subgroup of correctional officers, and even fewer focused on a different subgroup. The majority of studies also involved staff at US government-run adult prisons. Most but not all studies utilized Maslach’s Burnout Inventory. Research on the antecedents of job burnout among correctional staff is more common than research on the possible consequences or outcomes of job burnout. Interestingly, despite the empirical emphasis on antecedents of burnout, there has been almost no research on effective interventions designed to deal with correctional staff burnout. Based on this narrative review, significant gaps remain in the research on correctional staff burnout.  相似文献   
50.
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