Bacterial Degradation of Risperidone and Paliperidone in Decomposing Blood

The stability of two benzisoxazole antipsychotics was determined in vitro in decomposing porcine blood inoculated with bacteria, utilizing a high‐performance liquid chromatography with ultraviolet and fluorescence detection method for drug quantitation. Stability experiments for risperidone and paliperidone were conducted at 7, 20 and 37°C for 4 days using sterile and bacterially inoculated porcine blood. The drugs were stable in sterile blood at each temperature and in inoculated blood at 7°C, but degraded significantly in inoculated blood at 20 and 37°C. Complete loss occurred within 2 days when incubated at 37°C. The benzisoxazole‐cleaved degradation products for both drugs were identified as 2‐hydroxybenzoyl‐risperidone and 2‐hydroxybenzoyl‐paliperidone utilizing liquid chromatography quadrupole‐time‐of‐flight mass spectrometry and accurate mass measurements. The degradation products have been found in postmortem case studies, including one case where risperidone and paliperidone were not detected, indicating complete conversion can occur in situ.     

Analyzing Forensic Evidence Based on Density with Magnetic Levitation

This paper describes a method for determining the density of contact trace objects with magnetic levitation (MagLev). MagLev measurements accurately determine the density (±0.0002 g/cm³) of a diamagnetic object and are compatible with objects that are nonuniform in shape and size. The MagLev device (composed of two permanent magnets with like poles facing) and the method described provide a means of accurately determining the density of trace objects. This method is inexpensive, rapid, and verifiable and provides numerical values—independent of the specific apparatus or analyst—that correspond to the absolute density of the sample that may be entered into a searchable database. We discuss the feasibility of MagLev as a possible means of characterizing forensic‐related evidence and demonstrate the ability of MagLev to (i) determine the density of samples of glitter and gunpowder, (ii) separate glitter particles of different densities, and (iii) determine the density of a glitter sample that was removed from a complex sample matrix.     

Sentence disparity in the federal courts and the adoption of sentencing guidelines

Pressure in the 1970's to reform the sentencing process can be attributed to a change in perceived public sentiment regarding the utility of treatment and to the belief that sentencing disparity was a severe problem in the sentencing process. Primary reform occurred in the federal judicial system with the development and implementation of rigorous sentencing guidelines. An evaluation of sentencing patterns for one federal judicial district indicates that sentencing disparity was not severe. Most federal offenders are relatively mild and consistently receive relatively mild sentences.     

Repositioning American Public Administration? Citizen Estrangement,Administrative Reform,and the Disarticulated State

Levels of citizen estrangement from government in the United States have risen rather consistently since the late 1960s and have reached all‐time highs in recent years. Evidence is accumulating in political science research to suggest that public administrative theory may have contributed to this trend since the Progressive Era in the early 1900s. The authors develop this thesis by arguing that administrative theory in the United States has persistently portrayed public managers as “bridge builders” who link an expertise‐challenged citizenry to government in ways that emphasize bureaucratic over democratic administration. Moreover, despite claims of yet another “new” paradigmatic shift for the field, collaborative governance scholarship to date exhibits similar tendencies. To support this argument, the authors assess the common citizen‐marginalizing tendencies of three sets of administrative reforms in American public administration: the progressive, associationalist, and polycentric heritages. They offer counterarguments to this thesis and call for critical self‐reflection by the field and a more empirically robust research agenda on this topic.     

The Better Angels of Our Nature: How the Antiprejudice Norm Affects Policy and Party Preferences in Great Britain and Germany

Existing research on public opinion related to race and immigration politics emphasizes the role of prejudice or bias against minority groups. We argue that the social norm against prejudice, and individual motivations to comply with it, are crucial elements omitted from prior analyses. In contemporary Western societies, most citizens receive strong signals that prejudice is not normatively acceptable. We demonstrate that many majority‐group individuals have internalized a motivation to control prejudiced thoughts and actions and that this motivation influences their political behavior in predictable ways. We introduce measures capturing this motivation, develop hypotheses about its influence, and test these hypotheses in three separate experimental and nonexperimental survey studies conducted in Britain and Germany. Our findings support a dual‐process model of political behavior suggesting that while many voters harbor negative stereotypes, they also—particularly when certain contextual signals are present—strive to act in accordance with the “better angels of their natures.”     

Portfolio Saliency and Ministerial Turnover: Dynamics in Scandinavian Postwar Cabinets

Why do certain ministers remain in their post for years while others have their time in office cut short? Drawing on the broader literature on portfolio allocation, this article argues that the saliency of individual portfolios shapes ministerial turnover. The main argument is that ministerial dismissals are less likely to occur the higher the saliency attributed to the ministerial portfolio since ministers appointed to important posts are more likely to have been through extensive screening before appointment. Importantly, it is also posited in the article that the effect of portfolio salience is conditioned by government approval ratings: when government ratings are on the decline, prime ministers are less likely to reshuffle or fire important ministers than when approval ratings are improving. To test these claims, Cox proportional hazards models are applied to a new dataset on ministerial turnover in Scandinavia during the postwar period. The results strongly support the proposition that portfolio saliency matters for ministerial survival, and that this effect is moderated by government popularity.     

National Political Parties and European Governance: The Consequences of ‘Missing in Action’

This article first summarises the findings of a three-year research project on the Europeanisation of national party organisation, then proceeds to a critical analysis of the consequences for national as well as EU governance. The account begins with the general finding that mainstream centre-left and centre-right parties have not created new procedures to make their leaders more accountable for their actions in EU decision-making, nor expanded to any appreciable degree the number and/or influence of party personnel responsible in the area of EU matters. It then identifies three clusters of impact: a) public opinion and partisan discourse; b) the legitimacy of both MEPs and transnational party federations; and c) the dynamics of party government at the national level. The article concludes with discussion of the ‘democratic deficit’ inside parties and the merits of politicising the EU without taking into consideration the role of national parties.     

Party Change and Europeanisation: Elements of an Integrated Approach

The literature on party organisational change emphasises environmental factors as well as internal circumstances. The literature on Europeanisation and political parties privileges the EU as a key environmental factor in terms of change. This article combines insights from the party organisation and Europeanisation literatures in order to more precisely conceptualise the EU as a stimulus and therefore causal factor in party organisational change. Two types of party change are analysed, new party positions (MEPs and specialised EU party staff) and party leaderships' responses to internal dissent over the EU. Linking a specific form of EU stimulus to a particular party goal helps to explain certain types of change, while inter-governmental bargaining may produce uncertainty for domestic political actors thereby inducing defensive reactions.     

Accounting for the survival of minority governments: An examination of the French case, 1988–1991

This article examines the post‐electoral conditions under which minority governments operate. It is argued that a minority government will remain in office for so long as it enjoys the support of either a commitment to relations, to behaviour, or to outcomes. If no such commitments are forthcoming, then it will only continue to survive if there is a specific constitutional device upon which it can rely. This hypothesis is tested upon the situation in France during 1988–91. Here, Michel Rocard's minority government survived because it enjoyed a commitment to outcomes. On the occasions when this commitment was absent, the government resorted to the use of Article 49–3 of the Constitution in order to remain in office.