Plasma versus bone marrow desipramine: a comparative study

Correlation between plasma and bone marrow tricyclic antidepressants has not been studied before. Two groups of rabbits were given 10 and 20 mg of desipramine/kg body weight, respectively. Desipramine was administered to the animals once daily by mouth for 5 days. On the fifth day the animals were sacrificed and blood and bone marrow samples were collected and analyzed using a high performance liquid chromatographic (HPLC) method. Data showed that a correlation exists between bone marrow and blood desipramine. The bone marrow desipramine concentration increased as its blood levels increased. The average ratio of bone marrow to blood desipramine +/- S.D. (standard deviation) in both dosage groups was 37.2 +/- 4.46 with a range of 30.99-44.82. This investigation is promising and shows that bone marrow could be used as an alternative tissue in the absence of a suitable blood sample.     

Recovery of decomposed and skeletal human remains in the "Green River Murder" Investigation. Implications for medical examiner/coroner and police

The Green River Murder Investigation in King County, Washington, is currently the longest active serial murder investigation in U.S. history. During its course, over 26 separate scenes with from one to five victims each have been processed. The experience of the authors is presented in order to acquaint other agencies with techniques of outdoor scene processing that have evolved during recovery of remains from Green River and other skeletal cases.     

International Patent Law is Obsolete and Copyright is Obsolete

‘A book may be good for nothing; or there may be onlyone thing in it worth knowing; are we to read it all through?’(Samuel Johnson) This section is dedicated to the review ofideas, articles, books, films and other media. It will includereplies (and rejoinders) to articles, the evaluation of newideas or proposals, and reviews of books and articles both directlyand indirectly related to intellectual property law.

International Patent Law is Obsolete By Anna Mancini, 2006,New York: Buenos Books Price: US$35, Paperback, ISBN: 1-932848-17-7E-book Price: US$7, ISBN: 1-932848-16-9 Copyright is ObsoleteBy Anna Mancini, 2006, New York: Buenos Books Price: US$35,Paperback, ISBN: 1-932848-17-7 E-book Price: US$5, ISBN: 1-932848-19-3   In International Patent Law is Obsolete Dr Mancini's openingpremise is     

Teenage suicide in King County, Washington. I. Rates of suicide for 26 years

The population-adjusted rate of teenage suicide in King County, Washington, was reviewed for the 26 years from 1959 to 1984. For the entire period, the rate did not change significantly. An abrupt change did occur during the middle of this period, but, for reasons discussed in the text, this may well represent a change in procedures and philosophy of death certification rather than a real change in rate. Reasons for the apparent discrepancy with national statistics are discussed.     

Duration of the time to reconviction: Evidence from UK prisoner discharge data

Duration models were used to investigate reconviction risks for a sample of 34,126 offenders released from prison in England and Wales during 1998. Different versions of the Cox proportional hazards model were applied to a comprehensive data set covering several offense types. Factors such as age (modelled using bands rather than a linear or quadratic format), gender, convictions-history, and offense type were found to be strongly associated with the risk of reconviction. Interactions between factors were also included and it was shown that the discrepancy between the risk of reconviction for males and females became weaker as the number of previous convictions increased. The study helped identify the subgroups of offenders for whom reconviction risks are greatest and the times when they seem to be most vulnerable to reconviction. Implications are explored for the design of prisoner resettlement programs and the prioritization of offenders for more intensive forms of intervention.     

Spatial variation of refractive index in a pane of float glass.

In the statistical interpretation of forensic glass evidence it is standard practice to make the assumption of homogeneity of the refractive index (RI) of the source glass, or of localized homogeneity. However, the work of Locke and Hayes showed that, for toughened windscreen glass, this assumption might not be true. This work is well cited, but there appears to have been little follow-on published research. Furthermore, the toughening process is something known to affect the refractive index, and is a process that float glass does not undergo. Float glass is a major component of casework in New Zealand and for that reason it would be interesting to know whether the findings of Locke and Hayes apply when dealing with float glass. In this paper we describe an experiment similar to that of Locke and Hayes, systematically examining the variation of RI in a pane of float window glass. It was found that, although there were no systematic differences in refractive index, there were observable differences across the pane.