生物试样中巴比妥类药物固相提取柱上衍生化GC/MS分析

建立生物试样中常见巴比妥类药物的固相提取和柱上衍生化GC／MS分析法。将预制的血或肝分别在pH6．0和pH2.2的条件下过预活化的GDX－403吸附小柱，再用缓冲浪和蒸馏水各4ml顺序洗柱。最后用4ml丙酮／氯仿（1：1）溶剂洗脱样品，离心弃除水相，80℃挥至近干，用50μl乙醇定溶、取净化的样品2～4μl挥至近干，加20μl0．2molTMAH衍生化试剂，直接进样0.5μl，柱上衍生化GC／MS（GC）分析。在试验条件下，当血和肝分别添加2．0μg和5．0μg混合药物，回收率≥80％，相对标准差（RSD）优于±10％，检测限优于5ng（信／噪比≥2）。该法能有效地排除类脂物和组胺的干扰，可用于治疗量级药物分析和婴幼儿中毒案检验。     

Organizational Process,Rulemaking Pace,and the Shadow of Judicial Review

Scholars have long understood that structuring internal work processes into more hierarchical or team‐based arrangements has consequences for organizational outputs. Building on this insight, this research examines the relationship between how agencies organize their rulemaking routines and the resulting rules. Tracking the job functions of rule contacts for economically significant rules proposed over a four‐year period, the analysis demonstrates that expanding the breadth of personnel types closely involved in a rulemaking is associated with a reduction in the time it takes to promulgate the rule. However, increasing the pace at which rules are finalized is not without cost, as those completed faster appear more likely to be overturned when challenged in court. The article not only adds another dimension to empirical scholarship studying rulemaking, which has largely focused on how forces originating outside the agency affect rules, but also suggests the importance of considering competing priorities in designing rulemaking processes.     

Social and Political Cultural Effects on the Outcomes of Mediation in Militarized Interstate Disputes

The article investigates the relationship between cultural similarities and differences on the part of the representatives of contending states and mediators, and outcomes of mediation efforts in militarized disputes. A distinction is made between social culture, defined primarily in terms of religious identity, and political culture, defined according to the state's political system. Analysis of 752 mediation attempts in militarized disputes occurring between 1945 and 1995 yields support for the hypothesis that mediation is more likely to succeed when the parties are from similar social cultures. The results, however, suggest that the relationship is more complex than that suggested by a simple categorization of states based on Huntington's "clash of civilizations" thesis. We also find that mediation is more likely to succeed when the parties share democratic political cultures, a finding that is consistent with the cultural/normative explanation for the democratic peace.     

The Continuing Relevance of Marxism to Critical Criminology

Since the early 1990s, the ``new directions' in Critical Criminology have consciously excluded Marxism as being out-dated. This article critically assesses the fundamental theoretical shifts within critical criminology. It argues that Marxism remains as relevant as ever for analysing crime, criminal justice, and the role of the state. There is a great need for critical criminologists to redirect their attention back to Marxist theory by developing and extending its tools of critical theoretical analysis. This revised version was published online in July 2006 with corrections to the Cover Date.     

The failure of postmodern criminology

Postmodernism has recently washed up on the shores of criminology, and is the subject of considerable theoretical debate. This essay critically assesses some of the most trenchant and relevant components of the theoretical bases for postmodernism, and sketches out their applicability to criminology. It argues that postmodernism can be of little assistance to intellectuals committed to critique and fundamental social change. While postmodernists look down so severely at ‘old-fashioned’ ‘meta-narratives’ like Marxism, it is now they who are falling off the contemporary agenda, because they are dated and theoretically flawed. My main argument is that the theoretical imporverishment of postmodernism creates an obstacle to the development of a truly critical criminology. One of the current challenges of critical criminology is to amplify the critique of postmodern criminology and to reorient the trajectory of critical criminology away from the postmodern detour. The essay explores the historical context of the emergence of postmodernism, the modernist/ postmodernist era, deconstructionism, ‘meta-narratives’, idealism, form and content, fragmentation/pluralism/relativism, absence of progressive praxis, conservatism and Marxism.