Plasma versus bone marrow desipramine: a comparative study

Correlation between plasma and bone marrow tricyclic antidepressants has not been studied before. Two groups of rabbits were given 10 and 20 mg of desipramine/kg body weight, respectively. Desipramine was administered to the animals once daily by mouth for 5 days. On the fifth day the animals were sacrificed and blood and bone marrow samples were collected and analyzed using a high performance liquid chromatographic (HPLC) method. Data showed that a correlation exists between bone marrow and blood desipramine. The bone marrow desipramine concentration increased as its blood levels increased. The average ratio of bone marrow to blood desipramine +/- S.D. (standard deviation) in both dosage groups was 37.2 +/- 4.46 with a range of 30.99-44.82. This investigation is promising and shows that bone marrow could be used as an alternative tissue in the absence of a suitable blood sample.     

Recovery of decomposed and skeletal human remains in the "Green River Murder" Investigation. Implications for medical examiner/coroner and police

The Green River Murder Investigation in King County, Washington, is currently the longest active serial murder investigation in U.S. history. During its course, over 26 separate scenes with from one to five victims each have been processed. The experience of the authors is presented in order to acquaint other agencies with techniques of outdoor scene processing that have evolved during recovery of remains from Green River and other skeletal cases.     

WHEN TO USE AND WHEN TO AVOID MEDIATION

This article examines voluntary mediation and provides suggested criteria for attorneys in deciding whether or not to use mediation. The author discusses what mediation has to offer, what it takes to make it work, and important cautions for attorneys in deciding about the use of this process.     

Identification of the driver in two-rider motorcycle accidents. Inguinal contusion-laceration as an indication of the driver

In motorcycle accidents involving two riders, medicolegal identification of the driver is necessary when one or both riders die. It is particularly important in the latter case, because the survivor almost always insists that he or she was not driving. One characteristic injury that distinguishes the driver from the passenger is inguinal contusion-laceration (accompanied internally by pelvic fracture). This injury, caused by collision of the pelvis with the fuel tank, identifies the driver.     

Is full better than half? Examining the longitudinal effects of full‐day kindergarten attendance

Kindergarten policy varies widely both across and within states. Over the past decade, a number of states have instituted a full‐day kindergarten requirement and others are considering it as a way to increase educational achievement. Many parents also support full‐day kindergarten as a source of child care. This paper uses the Early Child Longitudinal Study–Kindergarten Class of 1998–1999 to evaluate the efficacy of this policy. In ordinary least squares, probit, county fixed effects, and instrumental variables models, we find that there are initial benefits for students and the mothers of students who attend full‐day kindergarten, but that these differences largely evaporate by third grade. Contrary to claims by some advocates, attending full‐day kindergarten is found to have no additional benefit for students in families with income below the poverty threshold. © 2006 by the Association for Public Policy Analysis and Management     

从“阳春白雪“到“下里巴人“——“易中天现象“析

"易中天现象"的核心是学术大众化的问题,而学术大众化的核心则是以什么方式、内容、目的走向大众的问题.从"易中天现象"中我们发现,学术要走向大众,必须具有大众化的传播和阐释方式、大众化的现实诉求和精神狂欢、大众化的价值多元和"海纳百川".具体到易中天讲座,则主要在于如何把握历史.易中天是通过灵动语言的当代阐释和以小寓大的文化批判来把握三国历史的.这是"易中天现象"火爆的真正原因和价值.     

承认关系的哲学思考

人的生存是需要体悟的,但更需要他者的承认。自我只有在他者的承认中才能把握生活的内涵,体会自身存在的意义和价值。所以,作为属人的社会,需要架构一种承认关系,这种承认关系不单单是认识或情感意义上的内在要求,更是文化积淀的一种生成,是人的生命活动的一种展开和实现。承认关系也体现了对自我的反思与感悟以及对他者的一种定位,对人本质的一种深层的注释,同时也内含有主体从自我生存意志出发对他者生存的一种体验。     

领导干部要保持党同人民群众的血肉联系

领导干部要保持党同人民群众的血肉联系,首先要深怀爱民之心,恪守为民之责。时刻牢记为人民服务的宗旨,开拓进取,为民谋事,才能调动人民群众的积极性,完成新世纪赋予我们的历史重任。     

农民贫困问题的思考

改革开放二十多年来,我国农民的生活确实发生了翻天覆地的变化,但是我们也应看到农民收入少且增长缓慢,社会福利待遇低,社会保障差,税费负担重。解决农民贪困的根本出路在于实现农业产业的转型、农村社会的转型、农民身份的转变和城镇化战略的推进。