Identification of more sequence variations in the D8S1179 locus

Routine STR-typing of 10,293 buccal swabs using different multiplex kits presented discordant D8S1179 profiles in four cases. Sequencing analysis identified a G-to-A transition upstream to the repeat, and an A-to-T transversion and a G-to-A transition downstream to the repeat. In the fourth case a four-base pair deletion downstream resulted in altered genotypes using different primer pairs. Current searching algorithms of the German DNA database are not capable of matching profiles that are divergent in only one STR-locus. Thus, to accommodate matching requirements and to avoid errors in individual genetic characterization for D8S1179, as described here, it is suggested that alternative primer pairs be used for routine genotyping as a matter of course.     

School Violence Prevention: Current Status and Policy Recommendations

The purpose of this article is to identify an array of strategies that are available to schools to address concerns school violence and to identify some of the potential school or school district policy options related to those choices. We illustrate that many promising options are available to schools to address violence and other inappropriate behavior of students. The very breadth and diversity of these options may pose a problem in attempting to develop a comprehensive local policy on this topic. While many schools have chosen increasingly punitive zero‐tolerance policies as their primary strategy of violence prevention, there is little or no research evidence documenting that such an approach can contribute to school safety. Rather, effective school violence prevention requires comprehensive planning involving documented best‐practice programs, preventive strategies, and effective responses to any violence that may occur. Since research documenting the effects of violence prevention strategies is inconsistent, it is incumbent upon schools to consider carefully which programs best meet the needs of their local situation, and to monitor the effectiveness of new programs in improving school safety and reducing disruption and incivility.     

A Consequentialist Framework for Prevention

Law and Philosophy - Douglas Husak contends that both criminalization and punishment can serve preventive goals, so long as they respect retributive culpability constraints. This Essay draws on...