Usefulness of DNA quantification in diagnosis of hypertrophic cardiomyopathies A preliminary study

Hypertrophic cardiomyopathies (HCM) are a frequent cause of sudden death in both young people and adults. Different cardiomyopathies can be distinguished according to the etiological agent and, although there are morphological differences too, alterations in the quantity of DNA in the cardiomyocytes may play an important role in their pathogenesis and evolution. To understand the characteristics and the behaviour of the DNA index in hypertrophic cardiomyopathies, we have studied thirty cases (10 primaries or essential, 10 hypertensives and 10 toxic) and compared the results with those obtained for 10 macroscopically normal hearts. The results showed that the different cardiomyopathies were statistically related with age, heart weight and ventricle thickness. The normal hearts showing a diploid DNA index, hypertensive cardiomyopathies (CM) hearts a tetraploid index and both toxic CM (1.1-1.9) and essential CM (>2) heart showing an aneuploid index. Statistically significant associations (p < 0.001) were observed when the DNA values were compared with the type of CM, the age, the thickness of both ventricles and the heart weight. Therefore, we think that the technique described may be of great help in the differential diagnosis of hypertrophic cardiomyopathies.     

The Adaptation of the FSLN: Daniel Ortega's Leadership and Democracy in Nicaragua

This article explores the capacity of the Frente Sandinista de Liberación Nacional (FSLN) to adapt to a changing Nicaraguan political environment over the last three decades. It focuses on the FSLN's transformation from the 1980s until its recent return to power. The analysis uses the tools offered by studies on the transformation and adaptation of political parties in adverse contexts. It concentrates on the four key stages of the FSLN's transformation: the 1980s, the five‐year period following the FSLN's defeat in the elections (1990–1995), the following decade in opposition (1996–2006), and the return to government. The key elements of the FSLN's adaptation relate to the centralization of party resources around the undisputed leadership of Daniel Ortega.     

Topological Variability of Fingerprint Ridge Density in a Sub‐Saharan Population Sample for Application in Personal Identification

Variability in ridge density in a sub‐Saharan population sample was studied by counting ridges in three fingerprint areas (two distal regions, radial and ulnar, and one proximal region) on the epidermal surface of the distal phalanx. Study material was obtained from the fingerprint impressions of 100 male sub‐Saharan subjects aged between 18‐ and 48‐years old. The results were compared with those obtained from a Spanish population sample. Sub‐Saharan males presented lower ridge density than Spanish males in the distal regions (radial and ulnar) of all fingers, whereas differences in the proximal region were only observed on some fingers. Using the differences observed between these populations, the likelihood ratio for inferring membership of one of the populations from a fingerprint of unknown origin was calculated; therefore, a ridge density of 14 or less for both areas (ulnar and radial), support an origin sub‐Saharan versus Spanish population.     

The Australian Experience of Municipal Amalgamation: Asking the Citizenry and Exploring the Implications

Debate over municipal amalgamations in Australian continues to dominate local government reform agendas, with the putative need to achieve economies of scale and scope consistently set against anti‐amalgamation arguments designed to preserve extant communities. Following from an examination of recent episodes of consolidation in Australia, this paper reports on citizens' attitudes to amalgamation garnered from a national survey of 2,006 individuals. We found that generally, citizens are ambivalent toward amalgamation, although attitudes were influenced by particular demographic characteristics and attitudes to representation, belonging, service delivery requirements and the costs thereof. The results suggest that, away from the local government sector itself, structural reform may not be the vexatious issue it is often portrayed as. The implications of this are explored here.     

Participatory communication for development in practice: the case of community media

Since it emerged, the field of communication for development has undergone a constant process of redefinition. Since the 1990s, the importance of participation in social and communicative processes has been stressed, and studies carried out during those years focused on participation as an important component to be considered. The so-called community media are privileged forces driving the participatory communication for development approach. Since their emergence and up to the recent studies, community media have been characterised by the centrality of citizenship participation in the creation of widespread messages, and in the processes of social change that they promote.

Communication participative pour le développement dans la pratique : le cas des médias communautaires

Depuis son apparition, le domaine de la communication pour le développement a traversé un processus constant de redéfinition. Depuis les années 1990, l'importance de la participation aux processus sociaux et de communication a été soulignée, et des études effectuées durant cette période-là se sont concentrées sur la participation comme élément important à prendre en compte. Ces « médias communautaires » sont des forces privilégiées qui impulsent l'approche participative pour la communication pour le développement. Depuis leur naissance et jusqu'aux récentes études effectuées, les médias communautaires se sont caractérisés par la position centrale de la participation citoyenne à la création de messages généralisés, et aux processus de changement social qu'ils promeuvent.

Comunicación participativa para el desarrollo en la práctica: el caso de los medios comunitarios

Desde que inició, el ámbito de la comunicación para el desarrollo ha experimentado un proceso constante de redefinición. A partir de los años noventa, ha comenzado a insistirse en la importancia de participar en los procesos sociales y comunicacionales. Los estudios realizados durante esa década, se centraron en la participación como componente primordial que debía ser tenido en cuenta. Los llamados medios comunitarios constituyen fuerzas privilegiadas que impulsan el enfoque de la comunicación participativa para el desarrollo. Desde que iniciaron sus actividades y hasta las últimas investigaciones realizadas al respecto, los medios comunitarios se caracterizaron por la significación otorgada a la participación ciudadana en la creación de mensajes de amplia difusión y en el proceso de cambio social promovido por dichos mensajes.

Comunicação participativa para o desenvolvimento na prática: o caso da mídia comunitária

Desde que surgiu, a área de comunicação para o desenvolvimento tem passado por um processo constante de redefinição. Desde a década de 1990, a importância da participação em processos sociais e comunicativos tem sido ressaltada e estudos têm sido realizados durante estes anos tendo como foco a participação como componente importante a ser considerado. A chamada mídia comunitária constitui-se em forças privilegiadas que dirigem a comunicação participativa para a abordagem de desenvolvimento. Desde o seu surgimento até estudos recentes, a mídia comunitária tem se caracterizado pela ênfase na participação dos cidadãos na criação de mensagens disseminadas e nos processos de mudança social que elas promovem.     

Distribution of the minutiae in palmprints: Topological and sexual variability

Palmprints have been systematically less studied than fingerprints, despite being of great use in the identification process. In Spain, they were not included in Automated Fingerprint Identification Systems (AFIS) until 2009. Very few investigations performed within the field of palmprints have assessed the sexual and population variability of the number and distribution of minutiae on its surface, despite the fact that these particularities are the basis for personal identification in forensic science. That is why a study was conducted to assess total, bimanual, and sexual density per morphological regions (superior or distal, thenar, and hypothenar) and per counting areas of 1 cm² on 120 palmprints obtained from 30 male and 30 female individuals of Spanish nationality. Also, the frequency in the location of each type of delta or triradius (a, b, c, d, and t) per count area was calculated. Results have shown a topological variability in the distribution of the density of minutiae, which is similar between sexes and a specular effect between both hands. The most frequent locations of the deltas coincide with areas of high minutiae density. It has also been shown that there are sexual differences in the total number of minutiae, which cannot be due to sexual dimorphism in adult hand size, since minutiae are established at an early stage of fetal development and their number will not change during later postnatal growth. These differences can only be attributed to genetic factors related to sexual determination.     

How do we provide the digital footprint with eternal rest? Some criteria for legislation regulating digital wills

This article analyses the implications of the death of digital service users on their digital footprint and assesses some of the solutions—contractual and legislative—that have been posited to date by digital service providers and by Parliaments of a few countries. In view of the different initiatives analysed, and the experience gained in their implementation, the paper presents legal certainty, effectiveness and transparency as criteria that should guide the regulation of the digital footprint in the case of death. These criteria must allow for the adoption or regulation of mechanisms for managing the digital footprint of digital service users to be clear and trustworthy for them and efficient and easily recognized and adopted by digital service providers.