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Steven Towler BS Marta Concheiro PhD Sue Pearring MS Luke N. Rodda PhD 《Journal of forensic sciences》2021,66(1):375-382
Performing point‐of‐care urine drug screen testing at autopsy by a forensic pathologist may provide an early indication of the presence of analytes of interest during autopsy. An evaluation for the screening of 14 classes of common drugs of abuse in postmortem urine by the point‐of‐care screening device, Alere iCup DX 14, is presented. One hundred ninety postmortem urine samples were screened with the iCup occurring at autopsy by the forensic pathologist. Positive and negative results obtained from the screening kit were evaluated against confirmatory test results obtained using routine forensic toxicology analyses that employed LC‐MS/MS and GC‐MS to detect a combination of over 85 common drugs of abuse and medications. Sensitivity for each respective iCup drug class ranged from 66% (buprenorphine) to 100% (methadone, tricyclic antidepressants). Specificity for each respective iCup drug class ranged from 89% (benzodiazepines) to 100% (amphetamines, barbiturates, buprenorphine, 3,4‐methylenedioxymethamphetamine, methadone). Positive predictive values ranged from 44% (benzodiazepines) to 100% (amphetamines, barbiturates, buprenorphine, methylenedioxymethamphetamine, methadone), while negative predictive values ranged from 96% (methamphetamine) to 100% (barbiturates, methadone, tricyclic antidepressants). A high false‐positive rate was yielded by the benzodiazepine class. The lack of fentanyl screening in the point‐of‐care device is a significant limitation considering its prolific prevalence in forensic casework. The results obtained in the study should be acknowledged when considering the use of the Alere iCup DX 14 in the context of postmortem casework to help indicate potential drug use contemporaneously with autopsy and when requiring such preliminary results prior to the release of a final forensic toxicology report. 相似文献
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Measuring Ethnic Fractionalization in Africa 总被引:3,自引:0,他引:3
Daniel N. Posner 《American journal of political science》2004,48(4):849-863
In most studies of the impact of ethnic diversity on economic growth, diversity is hypothesized to affect growth through its effect on macroeconomic policies. This article shows that most measures of ethnic diversity (including the commonly used ELF measure) are inappropriate for testing this hypothesis. This is because they are constructed from enumerations of ethnic groups that include all of the ethnographically distinct groups in a country irrespective of whether or not they engage in the political competition whose effects on macroeconomic policymaking are being tested. I present a new index of ethnic fractionalization based on an accounting of politically relevant ethnic groups in 42 African countries. I employ this measure (called PREG, for P olitically R elevant E thnic G roups) to replicate Easterly and Levine's influential article on Africa's "growth tragedy." I find that PREG does a much better job of accounting for the policy-mediated effects of ethnic diversity on economic growth in Africa than does ELF. 相似文献
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D N Vieira A E Pinto F O Sá 《The American journal of forensic medicine and pathology》1988,9(4):287-289
We report a case of homicide by hanging of a 29-year-old woman that was committed by her husband, who nearly escaped from justice. We offer some reflections on the rarity of this method of mechanical asphyxia in cases of homicide, and on the difficulties in the diagnosis of the medico-legal etiology of these situations. We also offer a short review of similar cases in the medico-legal literature. 相似文献
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In cases of fragment/broken long bones, it becomes difficult to measure the length of bones for the purpose of calculation of total height (stature) of the individual with the help of magnification factors. An attempt has been made to devise a method of calculating the bones length from fragments on three long bones of the upper extremity. 相似文献
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Sixteen deaths associated with the use of the Taser were examined. All involved young males who had a history of abuse of controlled substances; all but three were under the influence of cocaine, phencyclidine [phenylcyclohexylpiperidine (PCP)], or amphetamine. All were behaving in a bizarre or unusual fashion which necessitated calling the police. The cause of death was an overdose of drugs in eleven, gunshot wounds in three, heart disease and Taser shock in one, and an undetermined cause in one. All were considered to be under the influence of PCP by the police at the time of the incident. All were unarmed, which was the reason a Taser was used instead of a more lethal weapon. The conclusion reached after evaluation of these cases is that the Taser in and of itself does not cause death, although it may have contributed to death in one case. 相似文献
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