Using STR analysis to detect human DNA from exploded pipe bomb devices

This study investigated the possibility of recovering a bomb assembler's DNA from an exploded pipe bomb device. Metal and polyvinyl chloride (PVC) pipes were examined to determine if one surface type would allow better DNA recovery than the other. Ten subjects each handled components of one metal and one PVC pipe bomb. The bombs were exploded, the fragments were collected and swabbed using the double swab technique, and the samples were extracted, quantified, amplified, and genotyped using polymerase chain reaction/short tandem repeat (PCR/STR). Of the 20 bombs handled by the subjects, four bombs gave reportable results that matched the subject's known DNA profiles. An additional eight profiles, also matching the subject's known DNA profiles, were generated but were below the reportable threshold. There was no difference in the success rate of obtaining DNA profiles related to the use of either PVC or metal in the manufacture of the pipe bomb. The variables that appeared to have the greatest influence on the success of generating a DNA profile were the amount of fragmentation and subsequent recovery of the bomb fragments. It is suspected that successful DNA profiling could also be dependent upon the bomb assembler's propensity to slough skin cells on objects they handled.     

Allocating resources among AIDS research strategies

One of the central questions facing policy-makers is how to allocate limited federal funds among alternative AIDS research strategies. A rational answer requires judgments about both the prospects of scientific progress and the societal value of research outcomes. Using a decision-analytic approach, this paper examines the marginal returns from additional funding of basic biology, epidemiology and mathematical modeling, vaccine development and testing, treatment development and testing, and behavioral and social science. A survey of a recent Institute of Medicine Committee on AIDS was conducted to elicit scientific judgments on the prospects for scientific progress in each of the five areas. The scientists were quite capable of transcending their disciplinary orientation as reflected in the dominant sentiment in favor of more behavioral and social science research. A comparison of the actual FY 1987 AIDS research budget with the budgets recommended by the scientific experts also suggests that basic biological research deserves greater emphasis.This research was supported by the Andrew W. Mellon Foundation in the form of a grant to the Health Science Policy Working Group of the Harvard Division on Health Policy, Research and Education.     

Injury patterns in motor vehicle fatalities

A retrospective pilot study of motor vehicle incident fatalities was conducted to determine what relationships exist between injuries received by deceased drivers, passengers, and a control population of pedestrians, and some of the environmental factors existing at the time of the incident. A number of correlations were established between the types and locations of injuries received, seat belt use, position of the injured party, and so forth. A study of this type, if performed on a large enough population, could lead to predictive models for the determination of position of the victims within a motor vehicle at the time of a fatal crash, based on a unique clustering of injuries.     

Factors that impede and facilitate management careers of women in the Malaysian civil service

Female and male managers of the Malaysian civil service were surveyed in an attempt to elucidate the factors that have facilitated and hindered their careers. The emphasis in this article is on career differences between women and men. Many of the conditions which inhibit the careers of female managers elsewhere in the world were also reported by those sampled. Family requirements and resulting role conflict were evident. Many women have not married. There was some evidence of sexual harassment. There is a suggestion that women may suffer from low self-esteem and attribute their career progress primarily to luck. On the positive side, and despite a government policy that has resulted in more public resources for higher education being awarded to men than to women, women managers have achieved career success. This is largely because of the socioeconomic status of their parents and the apparent willingness of parents to educate female offspring who were not necessarily the first-born.     

Individualism,etatism, and the ACLU

Fred Siegel teaches at The Cooper Union in New York. Last year he served as Visiting Fellow at The Institute for Advanced Study in Princeton. He is working on a book about the decline of American imperialism and is editing a special issue of Dissenton social breakdown.     

Does ink age inside of a pen cartridge?

In questioned document examination and ink dating, it has been assumed that the ink inside of a pen cartridge does not begin aging until the ink is dispensed onto paper. Positive ion laser desorption (LD) mass spectra were obtained of ink-on-paper samples containing methyl violet, from new and old pens. Mass spectral studies with methyl violet have established the mechanism for how the dye degrades over time, and have provided structural information concerning the dye's degradation products. This information was used as an indication of the relative age of ink on paper. The LD mass spectrum of the ink from a new pen was indicative of "new" ink, whereas the spectra of the ink found in some older pens may appear to be either new or old. The ink from most of the old pens studied appears not to have aged, supporting the common assumption, whereas other ink samples produced "aged" ink spectra, suggesting otherwise.