Behavior of animal blood in blood typing systems. Isoelectric focusing of erythrocyte acid phosphatase and phosphoglucomutase

Isoenzyme band patterns of animal blood erythrocyte acid phosphatase (EAP) and phosphoglucomutase-1 (PGM) were studied by isoelectric focusing on ultrathin polyacrylamide gels. For blood from all animals tested (dog, cat, cow, sheep, and goat), the overall band patterns for both isoenzymes were different from those of the most common human types of these enzymes, although some animal EAP and PGM bands appeared in the human band areas. When mixtures of human and animal red blood cells were studied, it was found that misinterpretation of human types was possible only if the overall band pattern of the mixtures was ignored. For the animal blood tested, the strong PGM bands appearing outside the human band areas could be used as "markers" for the possible presence of animal blood in the samples tested.     

Complications following cell therapy

So far, the law in the Federal Republic of Germany still allows the injection of fresh-cell preparations from animals as a roborant to increase the vitality of the organism and to strengthen the body's immune defense system. The use of "sicca-cell" preparations was provisionally forbidden in 1987 by the Federal Health Organization (Bundesgesundheitsamt; BGA). Prohibition of fresh-cell injections would have exceeded the authority of this office, although the same serious reservations also applied in the case of this treatment method. Several publications that have appeared since 1955 have reported serious complications of this therapy, some life-threatening and some even lethal. Two further cases are now added: (1) A woman aged 69 had been receiving treatment with cell injections for 9 years. Immediately after an injection of sicca cells she collapsed and was hospitalized; 7 days thereafter she developed an ascending paralysis with increasing inability to swallow or breathe. She died 25 days after the injection as a consequence of central and peripheral respiratory failure. Autopsy revealed the alterations typical for acute Landry-Guillain-Barré-Strohl syndrome. (2) A 76-year-old healthy woman had been receiving treatment with fresh-cell preparations for several years. After an injection of cell suspensions a painful local swelling was observed. The symptoms were interpreted as the consequence of an iatrogenic local hematoma, and repeated punctures were performed to obtain blood. The patient was transferred to a surgical department for further therapy. Two days after the injection she suddenly died with signs of acute cardiovascular failure. Autopsy revealed the signs of a fulminating clostridial infection and also the characteristic signs of Landry-Guillain-Barré syndrome with involvement of the autonomic nervous system. In both cases the development of an inflammatory process in the peripheral nervous system could be interpreted as an immune-mediated allergic disease, related to the repeated injection of heterologous antigenic material containing nervous tissues. This hypothesis would also explain the two other cases already published and would be consistent with the observed perivenous leukoencephalopathy of the central nervous system. The human disease pictures correspond to the well-established animal models of EAEM (experimental allergic encephalomyelitis) and EAN (experimental allergic neuritis). The pathogenesis is discussed; the major role of the central and peripheral nervous system is stressed, with special reference to the risk of acute autonomic failure. The need for specific autopsy techniques for the investigation of the entire nervous system, including spinal cord, roots, spinal ganglia and peripheral nerves with sympathetic chains, is raised.     

The "utility" principle within the scope of forensic determination of blood kinship using serostatistics

A "realistic" prior probability is always based on case experience (Akten-a-priori). In serological opinions pertaining to parentage, the realistic prior probability is only one piece of information in the whole body of evidence before the judge and does not have any special significance per se. There is no such thing as a "neutral" prior probability. It either implies "ignorance," in which case it cannot be "information," or it must be taken in connection with the utility principle, in which case it is not a "probability." The utility principle is defined in law and cannot be expressed in figures. The utility principle takes effect only when the judge reaches a decision (on the basis of all the evidence before him). It determines the relative importance of the participant's objects of legal protection which are at issue in the case. The expert is bound to apply a neutral utility component, i.e., in a two-hypothesis case (the normal situation) the significance of both the null and the counter hypothesis must carry the same weight. A null and/or a counter hypothesis can combine several single hypotheses; the mean value of their frequencies is taken. As a rule, one should avoid using a "prior case probability" ("Akten-a-priori") when calculating a W value. An "expectation of error" should be as realistic as possible and hence be obtained using a "prior case probability."     

The cutaneous ink sign: a tipoff to suicide or suicide notes

The presence of smeared or unsmeared ink on the skin resulting from the writing process has been observed in a number of suicide victims who have left suicide notes. The authors report a case of a palmar "cutaneous ink sign" and discuss its forensic science import.     

Deaths allegedly caused by the use of "choke holds" (shime-waza)

Shime-waza or the "choke hold", when properly applied, should not cause death; therefore, its primary purpose should be to subdue violent suspects. When properly applied, the choke hold causes unconsciousness in 10 to 20 s. No fatalities as a result of shime-waza have been reported in the sport of judo since its inception in 1882. Among the methods of "control holds" taught to law enforcement officers is the choke hold similar or identical to shime-waza used in judo. Using the choke hold, officers may afford themselves maximum safety while subjecting the suspect to a minimum possibility of injury. The author has reviewed 14 fatalities with autopsy findings where death was allegedly caused by the use of choke holds.     

Reviews

Alexander Yanov, The drama of the Soviet 1960s: a lost reform. Institute of International Studies, University of California, Berkeley, 1984, 141 pp. $8.50.

Karen Dawisha, The Kremlin and the Prague Spring. Berkeley: University of California Press, 1984, xiv + 426 pp. £22.50.

Christer Jônsson, Superpower: Comparing American and Soviet Foreign Policy. London: Francis Pinter, 1984, viii + 248 pp. £18.50.

Joseph Nye, The Making of America's Soviet Policy. Yale University Press, 1984, £20.00.

Alexander Dallin, Black Box: KAL 007 and the superpowers. Berkeley and Los Angeles: University of California Press, 1985, xii + 130 pp. £14.25.

Alex Kozulin, Psychology in Utopia. Toward a Social History of Soviet Psychology, Cambridge Massachusetts, London: The MIT Press, 1984, xi + 179 pp. £16.65.

Timothy Edward O'Connor, The Politics of Soviet Culture. Anatolii Lunacharskii. Ann Arbor: UMI Research Press, and London: Bowker Publishing Company, 1984,193 pp. £35.50.

Alexander Vucinich, Empire of Knowledge. The Academy of Sciences of the USSR (1917–1970). Berkeley and London: University of California Press, 1984, x + 484 pp. £23.95

Lawrence Badash, Kapitza, Rutherford, and the Kremlin. New Haven and London: Yale University Press, 1985, xi + 129 pp. £20.00.

Mark Popovsky, The Vavilov Affair. Archon, Hamden, Connecticut, 1984, viii + 216 pp. £21.40.

Timothy Dunmore, Soviet Politics 1945–53 London: Macmillan Press Ltd., 1984, vi + 167 pp. £20.00.

George Ginsburgs, The Citizenship Law of the USSR, Law in Eastern Europe No. 25 (general editor F. J. M. Feldbrugge). The Hague, Boston, Lancaster: Martinus Nijhoff Publishers, 1983, 406 pp. £50.00.

R. F. Miller and F. Féhér (eds.), Khrushchev and the Communist World. London and Canberra: Croom Helm and Totowa, New Jersey: Barnes and Noble Books, 1984, 243 pp. £15.95.

Michael Haynes, Nikolai Bukharin and the Transition from Capitalism to Socialism, Beckenham, Kent: Croom Helm Ltd., 1985, vii + 136 pp. £14.95.

Bernd Bonwetsch (ed.), Zeitgeschichte Osteuropas als Methoden‐ und Forschungsprob‐lem. Osteuropaforschung: Schriftenreihe der Deutschen Gesellschaft fur Osteuropa‐kunde, Band 13. Berlin: Verlag Arno Spitz, 1985, 192 pp. DM 28,00.

Marie Lavigne, Economie Internationale des pays Socialistes, Paris: Armand Colin, 1985, 255 pp.

Marcel Drach, La crise dans tes pays de l'Est, Paris: Editions La Découverte, 1984, 127 pp. FF. 31.

L. Csaba, Kelet‐Europa a Világgazdaságban. (Eastern Europe in the World Economy), Budapest: Közgazdasági és Jogi Könyvkiadö, 1984, 316 pp., bibliography but no index.

Michael Shafir, Romania: Politics, Society and Economics, London: Frances Pinter, 1985, xvii + 232 pp. h/b £18–50, p/b £6.95.

Nicholas G. Andrews, Poland 1980–81. Solidarity versus the Party, Washington: National Defense University Press, 1985, xii + 351 pp.

Peter Raina, Poland 1981. Towards Socialist Renewal, London: George Allen & Unwin, 1985, vii + 472 pp. £20.00.

Stephen D. Kertesz, Between Russia and the West: Hungary and the Illusions of Peacemaking 1945–1947, London and Notre Dame: University of Notre Dame Press, 1985, xix + 299 pp. £18.95.

Mårta‐Lisa Magnusson (ed.), Bogen i Sovjet. Fra forfatter til laeser, Esbjerg: Sydjysk Universitetsforlag, 1985, 106 pp. p/b, 74–75 DK Kr.

Margit Nielsen, Udenrigsøkonomi i Østeuropa—tilpasning eller krise? Esbjerg: Sydjysk Universitetsforlag, 1985, 99 pp. p/b, 65–00 DK Kr.