Incidental findings in human subjects research: what do investigators owe research participants?

The use of brain imaging technology as a common tool of research has spawned concern and debate over how investigators should respond to incidental findings discovered in the course of research. In this article, we argue that investigators have an obligation to respond to incidental findings in view of their entering into a professional relationship with research participants in which they are granted privileged access to private information with potential relevance to participants' health. We discuss the scope and limits of this professional obligation to respond to incidental findings, bearing in mind that the relationship between investigators and research participants differs fundamentally from the doctor-patient relationship.     

A critical review of recent literature on crime and criminal justice in China: research findings,challenges, and prospects (Introduction)

Crime, Law and Social Change -     

Adolescent males with urogenital anomalies: Their body image and psychosexual development

Three midadolescent males with major congenital urogenital anomalies and multiple surgical repairs are described. Each patient had suffered repeated profound insults to body image concepts and gender identity from infancy onward, now clearly reflected in his psychosocial behavior and in figure drawings. Of major importance is the total lack at any time of counseling and emotional support as a part of comprehensive management. A plea is made for awareness of the psychological effects of such disorders and the need for long-range therapeutic planning from early childhood through adolescence to develop sound compensatory modes of coping with this stress.Formerly fellow in adolescent medicine, New York University Medical Center, at the time the material for this report was collected. Received his M.D. and pediatric training at Boston University School of Medicine and Boston City Hospital. Research interests include comprehensive health care for adolescents and the effects of illness on adolescent psychological development.Received his Ph.D. in psychology from Heed University, Miami, Florida, and training in psychology and child development at New York University. Research interests include the psychological effects of hospitalization on children and youth, minimal brain dysfunction, and developmental assessment in infancy.Received her M.D. from the University of Rochester, pediatric training at University of Minnesota Hospitals and Babies Hospital, New York City, and training in adolescent medicine at Beth Israel Hospital, New York. Research interests include psychological effects of illness and hospitalization in adolescents, legal rights of minors, and adolescent sexuality.     

Trade Secrets, Firm-Specific Human Capital, and Optimal Contracting

Trade secrets are innovations jointly produced by firms and employees that are generally not protected by patents. They are commonly protected within the framework of labor contracts, where an obligation of confidentiality is imposed upon the employee. Specifically this obligation applies to the employee even after he has left the employer for a period of time determined in the contract, known as a cooling off period. Often employees are prohibited not only from revealing trade secrets, but also from utilizing their specific human capital developed at the original place of employment in competitor firms during this period. Their specific human capital is in effect inseparable from the trade secret. Failure to protect the trade secret will result in its revelation and its becoming public and hence worthless for the innovator. The inability of an employee to reveal trade secrets and utilize his specific human capital after leaving his place of employment imposes costs and losses upon him. Some form of compensation will be paid for these contingent losses within the employment contract. Employers know that the longer the cooling off period imposed upon employees, the greater employees must be compensated for this in the contract. Longer cooling off periods thus cost the employer more, but also enable him to earn greater rents from the innovation itself. In this paper profit-maximizing periods of trade secret protection are derived, based on these two countervailing factors, and comparative statics exercises are performed. How the selection of profit-maximizing periods of trade secret protection when the incidence of resignation is itself affected by contract parameters and incentives is explored.     

A Competing Risks Model of Supreme Court Vacancies, 1789–1992

We hypothesize that Supreme Court justices will consider the likely ideological disposition of their successor in their decision to retire or remain on the Court. Furthermore, because a justice's decision to remain on the Court places him or her at risk of dying in office, it is necessary to consider a model of both voluntary and involuntary vacancies. Our study examines three broad classes of factors influential to Supreme Court vacancies: personal considerations, institutional context, and political influences. We assess the factors that affect the probability of a vacancy on the U.S. Supreme Court due to mortality and retirement at the individual level from 1789 to 1992, using a competing risk duration model and incorporating time-varying covariates. We find significant differences in the hazards of vacancy due to these two causes, and a number of factors are shown to influence the probability of a vacancy, including a general propensity to retire near the beginning of presidents' second terms. However, we find little evidence of the influence of political factors in either retirement-or death-related vacancies, suggesting that justices who retire do not generally do so for expressly political reasons and those who die in office rarely do so as a result of holding out for a like-minded replacement.