Providing justice and reconciliation: The criminal tribunals for Sierra Leone and Cambodia

The Special Court for Sierra Leone (SCSL) and the Extraordinary Chambers for Cambodia (ECC) represent a departure from the model established by the International Criminal Tribunal for the former Yygoslavia (ICTY) and the International Criminal Tribunal for Rwanda (ICTR). The SCSL and the ECC have often been referred to as “mixed” or “hybrid” tribunals in which there are significant domestic and international components. The tribunals include a combination of domestic and international judges, utilize domestic and international laws and are administered by a prosecutorial team composed of domestic and international lawyers. Many of these institutional changes have been brought about because of criticisms of the ICTY and the ICTR. The fundamental question of this article is whether these mixed tribunals are a more effective mechanism for providing justice and reconciliation than purely international solutions. This is an important question because both the international community and states are moving in the direction of mixed tribunals.     

Central nervous system consequences of an unusual body disposal strategy: case report and brief experimental investigation

The body of a 73-year-old man was dismembered by his female companion for the purpose of covert disposal. The method employed included skillful separation of body parts with hacksaw and knife, piecemeal disposal of fragments, and prolonged boiling of the decapitated head. The latter treatment resulted in marked shrinkage of cranial dura mater, separation of dura mater from skull, and extrusion of brain fragments into the resultant enlarged epidural space through a dural defect due to the disproportionately greater shrinkage of dura mater compared to brain parenchyma. This resulted in curd-like brain fragments filling an enlarged epidural space and overlying a shrunken, leathery dura mater. The cranial dura mater, still adherent to the skull base, resembled a "shrunken brain" in contour but contained only the remnants of brain tissue not already extruded through the dural defect. This unusual thermal artifact is rarely illustrated or mentioned in forensic literature. The development of this postmortem artifact likely requires the presence of a specific combination of conditions which must be, but apparently rarely are, simultaneously present.     

Pharmacogenomics as an aspect of molecular autopsy for forensic pathology/toxicology: does genotyping CYP 2D6 serve as an adjunct for certifying methadone toxicity?

Pharmacogenomics, applied as an aspect of molecular autopsy, may be used as an adjunct for certifying methadone fatalities. Methadone is metabolized by cytochrome P-450 (CYP) 1A2, 3A4, and 2D6. We hypothesized that methadone toxicity may be partially due to CYP 2D6 *3, *4, and *5 variant alleles, resulting in poor drug metabolism. A retrospective analysis was performed on covariables and risk factors of 21 methadone cases from the Milwaukee County Medical Examiner's Office (1998-2000). PCR genotyping showed: one heterozygous for 2D6*3, two homozygous for 2D6*4, five heterozygous for 2D6*4, and one heterozygous for both 2D6*3 and *4. This limited number of cases showed that the prevalence of poor metabolizer was higher but not significantly different from that of a control group (n = 23) (P > 0.05, Fisher Exact Test). Thus, CYP 2D6 mutations may not yet be directly associated with methadone toxicity. However, pharmacogenomics, complementing other case findings, served as an adjunct in interpreting methadone toxicity of poor and intermediate metabolizers.     

The Spatial Patterning of County Homicide Rates: An Application of Exploratory Spatial Data Analysis

The possibility that homicides can spread from one geographic area toanother has been entertained for some time by social scientists, yetsystematic efforts to demonstrate the existence, or estimate the strength,of such a diffusion process are just beginning. This paper uses exploratoryspatial data analysis (ESDA) to examine the distribution of homicides in 78counties in, or around, the St. Louis metropolitan area for two timeperiods: a period of relatively stable homicide (1984–1988) and aperiod of generally increasing homicide (1988–1993). The findingsreveal that homicides are distributed nonrandomly, suggestive of positivespatial autocorrelation. Moreover, changes over time in the distribution ofhomicides suggest the possible diffusion of lethal violence out of onecounty containing a medium-sized city (Macon County) into two nearbycounties (Morgan and Sangamon Counties) located to the west. Althoughtraditional correlates of homicide do not account for its nonrandom spatialdistribution across counties, we find some evidence that more affluentareas, or those more rural or agricultural areas, serve as barriers againstthe diffusion of homicides. The patterns of spatial distribution revealedthrough ESDA provide an empirical foundation for the specification ofmultivariate models which can provide formal tests for diffusion processes.