THE WILENSKI REVIEW

Since the early 1950s a spate of large-scale inquests on government administration has swept the English-speaking world, under governments of all political complexions. The phenomenon has received no general explanation, but its continuity has had certain practical advantages. It has added to the stock of techniques for conducting inquiries. It has suggested that linking investigation with implementation may reduce the risk of "pigeonholing". It has revealed the importance of political support for essays in reform. The experience also invites, by now, some reflections upon the role of vested interests in the reform process, the impermanence and relativity of particular recipes for reform, and the constant emergence of new perspectives for appraisal of administration. Although Professor Wilenski's Interim Report * is well over a year old, his Review is still in full swing, and is worth discussing not only on its own merits but also for the way it illustrates some of these points.
* Directions for Change: An Interim Report , by Professor Peter Wilenski, Commissioner, Review of N.S.W. Government Administration, Sydney, D. West, N.S.W. Government Printer, November 1977. Pp. ix + 353. Illustrations by Patrick Cook.     

Cardiac glycosides and metabolites--problems of recovery in tissue extracts. Separation of visible substance spots in the nanogram range (author's transl)]

The recovery measurements in rat tissues performed via i.p. injected radioactive digoxin derivates (3H-digoxin, 125J-digoxin derivative) showed that approximately 50% of the total glycoside content will be extracted. Thus, an addition of digoxin standards to drug-free tissues may lead to false negative determinations. By comparison of the radioactivity before and after extraction the following results were obtained: Recovery from tissues 3H-digoxin 50% 125J-digoxin 40% from serum 3H-digoxin 60% added to drug free tissue homogenates 3H-digoxin 85% After i.p. application of 15 mg/kg of beta-methyldigoxin to BD9 (Berlin)-rats the resulting tissue concentrations were extracted by Amberlite XAD-2. beta-Methyldigoxin and its metabolites digoxin and digoxinbisdigitoxide could be separated and distinguished from artifacts by fluorescence detection on HPTLC-plates with a detection limit of 60 ng/spot. Concentration determined by radioimmunoassay are in satisfactory agreement with HPTLC results.