Screening postmortem whole blood for oxycodone by ELISA response ratios

The objective of this study was to investigate the accuracy of screening postmortem whole blood for oxycodone using the ratio of the oxycodone immunoassay response to the response for the specimen obtained with a general opiate-class immunoassay. Fifty eight specimens which were negative for opiates and 158 postmortem whole blood specimens positive for opiates including 66 specimens known to contain oxycodone were assayed. Specimens were diluted 1:5 with assay buffer and analyzed by both the Neogen Oxymorphone/Oxycodone ELISA and the Neogen Opiate Group ELISA (Neogen Corporation, Lexington KY). The oxycodone equivalents in ng/mL from the Oxymorphone/Oxycodone ELISA were divided by the morphine equivalents in ng/mL from the Opiates ELISA to obtain an Oxycodone/Opiates Response Ratio. This ratio was compared with the GC/MS data for all specimens and for opiate positive specimens. Receiver Operating Characteristic (ROC) analysis suggested that optimum relative response ratio was 2.0. The sensitivity of the ELISA response ratio for the presence of oxycodone at a response ratio cutoff of 2.0 was 89.4% +/- 3.8% and the specificity was 88.1% +/- 3.2%. Specimens with a ratio of 2.0 or higher had a greater than 50% probability (positive predictive value) of containing oxycodone in a population with a greater than 15% prevalence of oxycodone.     

The use of quantitative light-induced fluorescence (QLF) to identify composite restorations in forensic examinations

There has been a large increase in the number of tooth colored restorations "white fillings" placed in recent years. An increased demand from the public for more aesthetic dental restorations causes a potential problem for forensic dentists who may find the fillings difficult to identify and hence include in postmortem odontograms. This has implications for the accuracy of dental identifications, particularly in situations where limited time is available for postmortem identification, e.g., mass casualty incidents. A new method for the detection of composite restorations is presented. Quantitative Light-induced Fluorescence (QLF) is a technique currently employed to detect small changes in enamel mineral content. An experiment was conducted to determine if the technique would afford a greater degree of contrast between composite and enamel and thus enable the accuracy of composite identification in enamel. Twenty-four previously extracted human premolars were gently cleaned with pumice and wet-and-dry paper. Twelve were subsequently randomly selected and restored on their buccal surfaces with Spectrum (a composite) following manufacturer's instructions. No attempt was made to color match the teeth and all were filled with shade B3. Twelve teeth were left unrestored. QLF and normal white light images were taken of both restored and non-restored surfaces with teeth wet and then dried. Ten forensic dentists were asked on two separate occasions (one month between each attempt) to indicate whether or not they thought the surface was: a) restored or b) unrestored. Results indicate that forensic dentists detected a significantly higher proportion (p<0.005) of filled surfaces with QLF.     

Introduction: Reflections on Two Decades of Congressional Budgeting

Even casual observers of federal policy making cannot help but notice the increasing preeminence of the Congressional budget process. The Congressional Budget and Impoundment Control Act of 1974, which created this process, brought forth profound changes in budgeting practices, both within Congress and between Congress and the president. In addition, the last decade has seen numerous attempts to use the process for deficit control. The goal of this special symposium is how congressional procedures-adapted over time-have affected the federal budgeting process. Each article examines the original purpose of the 1974 statute and analyzes the statute's impact over more than two decades.     

Allocution b I'occasion de la parution du Rapport de la Commission royale sur les peuples autochtones

Sommaire: Dans cette allocution, les co-présidents de la Commission royale sur les peuples autochtones présentent quelques-uns des principaux thèmes et conclusions du rapport final de la Commission. D'entrée de jeu, ils insistent sur l'urgence de changer la relation entre Autochtones et non-Autochtones au Canada. Dans sa forme actuelle, cette relation entraine un gigantesque gaspillage de potentiel, d'argent et de vies humaines, lequel est confirmé par les statistiques sur les taux de suicide, sur l'alcoolisme et la toxicomanie, sur l'incarcération, sur le chômage, sur la dépendance à l'égard de l'aide sociale, sur l'abandon scolaire préoce, sur le mauvais état de santé et sur les piètres conditions de logement. Le rapport propose une stratégie détaillée sur 20 ans pour restaurer la santé sociale, économique et politique des peuples autochtones et redéfinir leur relation avec l'ensemble des Canadiens. Cette stratégie comporte un double cheminement vers le changement: un nouvel équilibre des pouvoirs politiques et des ressources économiques, complété par un effort en we de restaurer la santé et l'efficacité des individus, des familles, des collectivités et des nations. Les co-présidents croient que le Canada devrait s'engager à réduire de 50% l'écart des conditions sociales et économiques entre Autochtones et non-Autochtones au cours des vingt prochaines années. Ils font valoir que le Canada ne peut plus se permettre de maintenir l'actuel régime de dépendance, de productivité perdue et de dépenses sociales sans cesse croissantes. En effet, on estime à un peu plus de 13 milliards de dollars la somme que tous les gouvernements vont dépenser en 1996 rela-tivement aux Autochtones. Cette wmme pourrait passer à plus de 17 milliards annuellement dans 20 ans, du seul fait de la croissance démographique. Abstract: In this article, the co-chairs of the Royal Commission on Aboriginal Peoples present some of the major themes and conclusions of the final report of the commission. From the outset, they insist on the urgency of altering the relationship between aboriginal and non aboriginal people in Canada. As it now stands, that relationship is one of waste: wasted potential, wasted money, wasted lives. It is measured in statistic after statistic: in the rates of suicide, of substance abuse, of incarceration, of welfare dependance, of low educational attainment, of poor health and poor housing. The report proposes a comprehensive strategy over 20 years to restore the social, economic and political health to aboriginal peoples and rebuild their relationship with all Canadians. It entails the pursuit of two mutually reinforcing paths to change: rebalancing political authority and economic resources; and a reinforcing effort to restore health and effectiveness to individuals, families, communities and nations. It is the co-chairs' belief that Canada should commit to reducing by fifty per cent the gap between the social and economic condition of aboriginal and non aboriginal people over the next twenty years. They point out that Canada can no longer afford to maintain the current regime of dependency, lost productivity and ever-growing social expenditures. Indeed, the amount all governments will spend in 1996 in relation to aboriginal peoples is estimated at just over $13 billion. This could rise to over $17 billion annually in twenty years as a result of demographic pressure alone.     

Was erklärt politische Patronage in den Ländern Westeuropas? Defizite des politischen Wettbewerbs oder historisch-formative Phasen der Massendemokratisierung

Every major paradigm in the social sciences since the 1950s has offered its own explanation for the varying incidence of party patronage and political clientelism in modern democracies. Today the two main contenders are (RC-based) positive political economy and historical institutionalism. Positive political economy emphasizes the crucial importance of effective political competition as a control device against the ever present temptation for politicians to use ‘improper political practices’ like patronage or clientelism. Historical institutionalism highlights the importance of formative moments in the history of democratic mass mobilization and party formation. The article argues that both approaches suffer from considerable weaknesses. The article proposes a modified historical-institutionalist explanation, which emphasizes the importance of state formation rather than party formation and which explains varying degrees and different forms of political patronage in Europe with different paths of modern state-building.