AN IMPACT IDENTIFICATION METHOD FOR DEVELOPMENT PROGRAM EVALUATION

Evaluation is essential to planning and implementing effective develop- ment programs. The resource limitations, multidimensionality of develop- ment program impacts, cultural barriers between evaluators and those impacted, and the diversity of settings in which evaluations must be con- ducted arc serious constraints on the use of traditional research methods to evaluate development programs. Similar constraints are faced in con- ducting most social impact assessments. We suggest that a method of impact identification that makes use of experts, including the people ef- fected by a project, can be used in development project evaluation. The method, which is based on the noniinal group technique, is described, as are some of its applications in Latin America and the Caribbean. We conclude iiy considering directions for future development and the relationship be- tween planning, evaluation, and impact assessment.     

Stability of plasma total cholesterol, triglycerides, and apolipoproteins B and A-I during the early postmortem period

The stability of plasma lipids and apolipoproteins during the early postmortem period was studied by taking four duplicate blood samples from eight cadavers 2, 6, 12, and 24 h after death. The bodies were kept at +4 degrees C. The plasma samples were analyzed for total cholesterol (TC), triglycerides (TG), apolipoprotein B (apo B), and apolipoprotein A-I (apo A-I). In TC, values rose by 6 and 11% in two cases, and in six cases diminished 3 to 15% during the first 6 h compared to values obtained 2 h postmortem. The greatest changes were a continuing rise in one case by 33% and a fall by 21% in another case during 24 h. In TG values marked changes took place including one case with a rise of 67% within 24 h. The concentrations of apo B rose by 9 to 11% in three cases and fell by 3 and 4% in two cases during 6 h, but during the whole study period a rise up to 78% occurred. In the concentrations of apo A-I, cases fell by as much as 42% in 6 h, and in one case rose by 20% during 6 h. The results indicate that unpredictable fluctuations occur in plasma lipid and apolipoprotein values within 24 h after death, and they should be interpreted cautiously if the samples have been taken after a prolonged postmortem period.     

Isoelectric focusing studies on the PGM1 subtypes in the northern Japanese population

The distribution of the human red cell phosphoglucomutase (PGM1) subtypes in samples from Japanese population (n = 277) living in the Miyagi Prefecture, the northern part of Japan, was investigated by applying the thinlayer polyacrylamide gel isoelectric focusing. In our population sample all the ten common phenotypes were demonstrated, and the estimated allele frequencies for the genes PGM1+1, PGM1-1, PGM2+1, and PGM2-1 were 0.671, 0.107, 0.161, and 0.061, respectively. Family studies (n = 40) indicated an autosomal codominant inheritance and confirmed the four alleles. The new system will increase the probability of exclusion in paternity cases among Japanese to 29.4% compared with 14.3% if the two allele system is used.     

State support under the new federalism

The new federalism will reduce total intergovernmental revenues to local governments. The reduction will be due to both the transfer to the states of much of the federal aid which previously flowed directly to local governments and reductions in total federal aid levels. Pass-through requirements on the shifted aid will not affect this general result but may soften the impact in many states. Because of differences in the extent to which state governments substitute federal pass-through aid for state aid from own-source revenues and in the degree to which different sources of revenues are treated differently by the states, local revenue reductions will vary greatly from state to state. The losses for local governments will range from 100% of the shifted aid in some states to as little as 15–20% in others.     

The investigation of the density of human hair in the forensic medical expert assessment of its similarity

Principally new, simple and objective method for investigation of human hair density is suggested. Hair identity in relation to a concrete person can be confirmed or excluded by statistical processing of the results obtained.     

Hepatotoxicity of dichloromethane

We studied hepatotoxicity of dichloromethane using primary cultures of parenchymal cells (hepatocyte) from adult rat livers. The production of carbon monoxide from dichloromethane increased with time, the increased cell number, and the concentration of dichloromethane. However, the carbon monoxide production per hepatocyte decreased with increasing cell density. When dichloromethane was in a high concentration, the metabolism of dichloromethane to carbon monoxide was extensively depressed, total glutamic-oxaloacetic transaminase (GOT) and mitochondrial GOT (m-GOT) levels in the cultured medium were extensively elevated, and the cultured hepatocytes were destroyed by dichloromethane. A case of accidental exposure to dichloromethane which occurred in Japan was also considered, and it is suspected that the inhalation of dichloromethane vapors in a high concentration for many hours may cause hepatotoxicity.