Toward purposeful individual capacity strengthening: alternative considerations for Western NGOs

The international donor community continues to emphasise country-led development strategies designed to equitably engage public and civil society agents in managing development assistance. Similarly donors who fund Western NGOs to implement development programmes on their behalf in recipient countries are increasingly pushing for cost-effective programme implementation that actively engages local actors. This article proposes an alternative theoretically grounded model for individual capacity strengthening to responsive and mission-driven Western NGOs that claim to be committed to ideals of capacity strengthening and indigenisation of programme leadership.     

Chemical identification and optimization of the 4-aminophenol colorimetric test for the differentiation between hemp-type and marijuana-type cannabis plant samples

The 4- Aminophenol (4-AP) colorimetric test is a fast, easy-to-use, and cost-effective presumptive assay of cannabis plant material producing different chromophores with THC-rich cannabis (blue color) and with CBD-rich cannabis (pink color). The main drawback of the 4-AP test is a brief observation window where the color rapidly changes to black, limiting the utility of the test. We now report for the first time, the identification of the product chromophores between 4-AP and CBD/THC as well as propose an explanation and a solution for the color degradation of the chromophores. The identification of the chromophores is provided by spectroscopic (UV–Vis), chromatography, and mass spectrometry (TLC and LC-QToF-MS). Oxidation of excess 4-AP (Reagent A) in the presence of NaOH (Reagent B) produces the black color observed for the previously reported 4-AP tests and reported in the literature. The adjustment of reactants concentrations and volumes of 4-AP:THC/CBD to a 1:1 ratio significantly reduces the black oxidation by-product and increases the observation window up to 2 h instead of the previously reported 5–10 min. For the first time, mass spectrometry and chromatography confirmed that the reaction of THC and CBD with 4-AP produced chromophores with m/z (M + H) = 420, consistent with proposed indophenol structures. The TLC method developed confirmed the separation between CBD and THC chromophores. The specificity of the test is also reported, showing false positive results for the presence of THC (blue color) for samples of thyme and oregano. LDA and SIMCA models showed that the optimized 4-AP procedure performs better than the previously reported 4-AP color test.     

Emergence of fentanyl-related deaths in Travis County,Texas and surrounding areas: A retrospective review of postmortem fentanyl-related drug toxicities from 2020 to 2022

The opioid epidemic has affected the United States (US) for decades with fentanyl and its analogs accounting for a recent surge in morbidity and mortality. Currently, there is a relative lack of information characterizing fentanyl-related fatalities specifically in the Southern US. A retrospective study was conducted to examine all postmortem fentanyl-related drug toxicities in Travis County, Texas, encompassing Austin (one of the fastest-growing cities in the US), from 2020 to 2022. Fentanyl contributed to 2.6% and 12.2% of deaths submitted for toxicology between 2020 and 2022, respectively, representing a 375% increase in fentanyl-related deaths over this 3-year period (n = 517). Fentanyl-related fatalities primarily occurred in males in their mid-30s. Fentanyl and norfentanyl concentrations ranged from 0.58 to 320 ng/mL and 0.53 to 140 ng/mL with mean (median) concentrations of 17.2 ± 25.0 (11.0) and 5.6 ± 10.9 (2.9) ng/mL, respectively. Polydrug use was present in 88% of cases, with methamphetamine (or other amphetamines) (25%), benzodiazepines (21%), and cocaine (17%) representing the most frequently identified concurrent substances. Co-positivity rates of various drugs and drug classes widely varied over time. Scene investigations reported illicit powder(s) (n = 141) and/or illicit pill(s) (n = 154) in 48% (n = 247) of fentanyl-related deaths. Illicit oxycodone (44%, n = 67) and illicit “Xanax” (38%, n = 59) pills were frequently reported on scene; however, toxicology only identified oxycodone and alprazolam in 2 and 24 of these cases, respectively. The results of this study provide a better understanding of the fentanyl epidemic in this region creating an opportunity to promote increased awareness, shift focus to harm reduction, and aid in minimizing public health risks.     

Der European Research Council als Ordnungsanspruch des europäischen Projekts im akademischen Feld

The European Union wants the “European Research Area” to become a process with its own competitive dynamics between national academic traditions and the global hegemony of US research. At first glance, such a Europeanization of Higher Education is vertically posited by the EU Research Framework Programmes. In addition and beyond that, the European Research Council (ERC) establishes a genuinely European academic logic fueled by strategies aimed at scientific autonomy. It does so by creating competition in accordance with meritocratic rules of academic legitimacy. As a result, both governance-oriented and critical idealist elites actively relate to the ERC as a European institution and bestow it with the ability of consecrating academic excellence. As a consequence, they contribute to the discursive construction of a European order characterized by a symbolic and material integration of elites, the opening up of national fields and the primacy of economic competition.     

Pandemics,economic freedom,and institutional trade-offs

European Journal of Law and Economics - We argue that institutions are bundles that involve trade-offs in the government’s ability to provide public goods that affect public health. We...     

A New Approach to the Interpretation of the French Constitution in Respect to International Conventions: From Hierarchy of Norms to Conflict of Competence

Netherlands International Law Review -     

The organisational and geographic diversity and innovation potential of EU-funded research networks

The Journal of Technology Transfer - Public funding of research improves the systemic conditions of entrepreneurial ecosystems. It provides early-stage financing to technologies that form the basis...