A simplified clustering method for novice narcotic chemists

Statistical classification remains the most useful statistical tool for forensic chemists to assess the relationships between samples. Many clustering techniques such as principal component analysis and hierarchical cluster analysis have been employed to analyze chemical data for pattern recognition. Due to the feeble foundation of this statistics knowledge among novice drug chemists, a tetrahedron method was designed to simulate how advanced chemometrics operates. In this paper, the development of the graphical tetrahedron and computational matrices derived from the possible tetrahedrons are discussed. The tetrahedron method was applied to four selected parameters obtained from nine illicit heroin samples. Pattern analysis and mathematical computation of the differences in areas for assessing the dissimilarity between the nine tetrahedrons were found to be user-convenient and straightforward for novice cluster analysts.     

Gas chromatographic method validation for the analysis of major components in illicit heroin seized in Malaysia

Apart from routine analysis of total morphine content required by the criminal justice system, quantification of other major components in illicit heroin has not been considered by the Malaysian enforcement laboratory. In order to quantify various other cutting agents in addition to alkaloids, a gas chromatographic (GC) method was developed to facilitate simultaneous quantification of eight target analytes commonly found in illicit heroin seized in Malaysia within a 12 min run time. The validation results demonstrated high selectivity with the use of an HP Ultra 2 capillary column. Different solvents were studied and methanol:chloroform (1:9) proved best for sample dissolution. The method was repeatable and reproducible. The study ranges covering 50-150% of the preferred concentrations of the eight analytes obtained r(2)>0.9997. Limits of detection up to 6μg/mL were also obtained and the method achieved 99-102% recovery. The capability of the method in heroin profiling was verified using samples from ten case samples.     

Concentrations of zolpidem and zopiclone in venous blood samples from impaired drivers compared with femoral blood from forensic autopsies

The concentrations of zolpidem and zopiclone were determined in peripheral blood samples in two forensic materials collected over a 10-year period (2001-2010). The z-hypnotics were determined in venous blood from living subjects (impaired drivers) and in femoral blood from deceased persons (forensic autopsies), with the latter classified as intoxication or other causes of death. The z-hypnotics were determined in blood by capillary column gas chromatography (GC) with a nitrogen-phosphorous (N-P) detector after solvent extraction with n-butyl acetate. The analytical limit of quantitation (LOQ) was 0.02mg/L for zopiclone and 0.05mg/L for zolpidem and these have remained unchanged throughout the study. When death was attributed to drug intoxication (N=918), the median concentration of zopiclone in blood was 0.20mg/L compared with 0.06mg/L for other causes of death (N=1215) and 0.07mg/L in traffic offenders (N=691) (p<0.001). Likewise, a higher median concentration (0.30mg/L) was found in intoxication deaths involving zolpidem (N=357) compared with 0.13mg/L for other causes of death (N=397) or 0.19mg/L in impaired drivers (N=837) (p<0.001). Median concentration in blood of both z-hypnotics were appreciably higher in intoxication deaths when no other substances were identified; 0 70mg/L (N=12) for zopiclone and 1.35mg/L (N=12) for zolpidem. The median concentrations of z-hypnotics in blood decreased as the number of co-ingested substances increased for intoxication deaths but not other causes of death. The most prevalent co-ingested substances were ethanol in autopsy cases and diazepam in the motorists. This large compilation of forensic cases should prove useful when toxicologists are required to interpret concentrations of z-hypnotics in blood samples in relation to cause of death.     

Power through trade: opportunities and constraints of the European Union’s norm entrepreneurship—the case of Hong Kong

Asia Europe Journal - The economic, trade, and cultural relations between the European Union (EU) and Hong Kong are widely recognized in the existing literature to be the most beneficial and...     

Governing the Economic Transition: How Taiwan Transformed its Industrial System to Attain Virtuous Cycle Development

This study explores the transitional processes of Taiwan's innovation system over the past half century, evolving from being rooted in traditional industries to attaining development in a virtuous cycle of development. Our approach is inspired by the Arena of Development theory and acknowledges the system of transformation failures, in which we highlighted the types of failures that might impede economic progress and how they were overcome in the evolutionary targeting of Taiwan's industrial development. Our findings demonstrate that the success of Taiwan's economic transition is targeted on, and evolves with, a series of macrolevel policies in the early phase of development; mesolevel institutional mechanisms to attain the industrial emergence settings; and, in pursuit of the virtuous cycle of development, the microlevel collaboration platform. We attribute the success of Taiwan's industrial system to this series of systematic government interventions. This study provides novel and salient normative principles that guide transformational policymakers in governing transitional processes of innovation system.     

No More “Local” Insurrection or Terrorism: The Dark Side of the Cobweb

World Society was the leitmotif of John Groom. It was a pluralist vision of International Relations set against Realism and state hegemonies. In this, it sought to establish an enhanced pluralism, citizen organisation and action, as a norm. It was a prescient forerunner of what we now commonly recognise as international civil society. Groom’s other resonant work on third-party and Track II mediation—citizen agency and intervention on behalf of norms of shared needs and equality—was an expression of that. However, all this took place within the context of an interlinked world system described as a cobweb. Not only did this model fail to predict the spiders and slaughter in today’s cobweb, it shared an Enlightenment view of civil society as secular. This paper talks about religious spiders and the sort of atrocious but anti-hegemonic pluralism that is now vexatiously glued to all we do internationally. However, the paper recognises that, reconfigured, Groom’s work laid first foundations for today’s International Relations.     

Taking Action to Stop Violence: A Study on Readiness to Change Among Male Batterers

The Transtheoretical Model of Change (TTM) predicts that matching interventions with a person’s readiness to change should improve treatment outcomes. This cross-sectional correlational study examined characteristics that affected self-reported readiness to change abusive behavior among a sample of 109 men in a 52-week batterer treatment program. Participants completed measures of anger/hostility, readiness to change, manipulative parenting, and self-esteem. Results indicated that contemplation of the impact of abuse has the highest unique relationship with self-reported taking action to stop violence. Moreover, physical aggression and manipulative parenting account for significant variance in the scores associated with self-reported taking action to stop violence as well. These findings suggest that interventions aimed at moving clients into contemplation, and reducing physical aggression and manipulative parenting styles, may increase the likelihood that batterers will take action to stop violence.