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11.
Anders Buchard M.Sc. Kristian Linnet M.D. D.M.Sc. Sys Stybe Johansen Ph.D. Julie Munkholm M.D. Michael Fregerslev M.D. Niels Morling M.D. D.M.Sc. 《Journal of forensic sciences》2010,55(2):457-463
Abstract: We investigated toxicological and pharmacogenetic factors that could influence methadone toxicity using postmortem samples. R‐ and S‐methadone were measured in femoral blood from 90 postmortem cases, mainly drug users. The R‐enantiomer concentrations significantly exceeded that of the S‐enantiomers (Wilcoxon’s test, p < 0.001). The samples were divided into four groups according to other drugs detected (methadone only, methadone and strong analgesics, methadone and benzodiazepines, or methadone and other drugs). There was no significant difference in any of the R‐methadone/total methadone ratios among the four groups. The median R/S ratio was 1.38, which tends to be higher than that reported for the plasma of living subjects. In addition, we investigated whether small nucleotide polymorphisms in the MDR1 gene that encode the drug transporter P‐glycoprotein were associated with the concentrations of R‐ and S‐methadone and its metabolite 2‐ethylidene‐1,5‐dimethyl‐3,3‐diphenylpyrrolidine. No significant association was detected. 相似文献
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Kristian Lasslett 《Crime, Law and Social Change》2010,54(1):1-19
This paper proposes to examine some of the core philosophical issues to have arisen out of the recent calls to move “beyond
criminology”. It will be claimed that the dismissal of crime as a “fictive event” is premature, as crime does indeed have
an “ontological reality”. Nevertheless, it will be asserted that the relation between harm and crime is contingent rather
than necessary. Accordingly, this paper will argue that there is merit to the claim that we should unify research on social
harm through the creation of a new field, a step which would have the added benefit of constructing an alternative venue for
crimes of the powerful scholars who wish to explore the destructive practices of states and corporations unconstrained. This
paper, therefore, will also offer a dialectical definition of social harm based upon classical Marxist strains of ontological
thought. 相似文献
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Kristian Gustafson 《Intelligence & National Security》2013,28(5):589-610
The article deals with the role and benefit added by the use of horizon scanning in intelligence analysis in the UK. It asserts that horizon scanning as a technique, while not entirely akin to the tradecraft of intelligence analysis, has much to contribute to its success. Specifically, is asserts that a horizon scanning function in the JIO and the Cabinet Office should be made permanent, as bureaucratic tumult in the wake of the 2010 SDSR have left the capability un-staffed, though still established. Within the UK intelligence community, such an organization may have positive roles to play in the processes of challenge, the setting of collection priorities, and overall long-term UK intelligence assessment at the national level. 相似文献
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Kristian Berg Harpviken Ananda S Millard Kjell Erling Kjellman Bernt A Ska˚ra 《Third world quarterly》2013,34(5):889-908
The ability to assess the impact of humanitarian interventions is key both for priority-setting and for maximising the quality of projects. Humanitarian mine action (hma) is a young sector, where the application of impact assessment is still in its infancy. In this article we will briefly revisit the history of impact assessment in hma, before reviewing the strengths and weaknesses of three different impact-assessment approaches: 1) the Landmine Impact Survey; 2) economic analysis; and 3) community studies. Each of the approaches has its own merits as well as its own shortcomings and the selection of one approach, or several approaches combined, needs to be informed by the particular conditions in a given setting. We argue that hma should always be based on sound impact-assessment practices, but also that it is important to encourage a general understanding of broader impact issues—as opposed to narrow output definitions—among all relevant stakeholders. In spite of considerable progress over the past few years on this issue, impact in mine action is still largely perceived as an event rather than an integral part of the process and specialised units responsible for impact assessment isolate this activity from day-to-day field management. 相似文献
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Recent discussions in development have moved away from holistic theorisation towards more localised, empirical and inductive approaches. In development practice there has been a parallel move towards local ‘participation’ and ‘empowerment’, which has produced, albeit with very different agendas, a high level of agreement between actors and institutions of the ‘new’ Left and the ‘new’ Right. This paper examines the manifestations of this move in four key political arenas: decentralised service delivery, participatory development, social capital formation and local development, and collective actions for ‘radical democracy’. We argue that, by focusing so heavily on ‘the local’, the see manifestations tend to underplay both local inequalities and power relations as well as national and transnational economic and political forces. Following from this, we advocate a stronger emphasis on the politics of the local, ie on the political use of ‘the local’ by hegemonic and counter-hegemonic interests. 相似文献
16.
Kristian Stokke 《Third world quarterly》2013,34(6):1197-1201
Abstract This paper analyses the Indian government's policy response to the Trade-related Intellectual Property Rights Agreement (trips) and examines the implications of this response for food security and farmers. trips has become one of the most controversial agreements of the wto. This is because of its wide and far-reaching mandate and its complex socioeconomic implications. It is argued that the changes made to the Indian Patents Act in response to trips will compromise the food sector and the rights of small farmers by conferring strong rights on upstream agents who produce proprietary agricultural inputs using biotechnology. Not only are these agents able to exert monopoly price control over agricultural inputs for 20 years, they also have the right to determine the conditions under which farmers and researchers use patented processes and products. The paper outlines policy options available to the Indian government to tighten the scope of patentability in the food sector. 相似文献
17.
Kim Kristian Moeller 《Crime, Law and Social Change》2009,52(4):337-345
A recent change in Danish cannabis control policy has had significant implications for the structure of the retail-level cannabis
market in Copenhagen. A process of restructuring following an crackdown on ‘Pusher Street’ has involved at least four people
getting shot and killed in what police describe as struggles for market shares. Combating the retail cannabis market was a
top three priority for the Copenhagen police. The shift in policy started in 2004 when possession for personal use was up-penalized,
from a discriminatory warning to an obligatory fine of 70 euros which was quadrupled in 2007. The law was immediately followed
by an extensive police crackdown on Christiania’s open retail-market. Christiania has had a cannabis market for 32 years.
As cannabis use rates rose throughout the ‘90’s the market flourished. On a given day it’s estimated turnover was around 20 k,
about twothirds of the total market in Copenhagen. On the 16th of May 2004 police raided ‘Pusher Street’ and arrested 60 dealers
and their helpers along with 20 people accused of forming an organized lookout corps. After the initial raid police implemented
a zero-tolerance zone in the area and targeted users in a deterrent effort issuing a total of 4834 fines in a year. Maintaining
the zero tolerance zone has so far involved 12 big confrontations with the inhabitants of Christiania. 114 police officers
have been injured and 29 formal complaints of police conduct have been lodged with the State Attorney. Following the crackdown
the cannabis market adapted by dispersing and applying new methods for retail dealing. 相似文献
18.
Linnet K Johansen SS Buchard A Munkholm J Morling N 《Forensic science international》2008,179(1):78-82
On the basis of simultaneously sampled postmortem blood specimens from the left and right femoral veins the pre-analytical variation of methadone measurements was evaluated and compared to the analytical variation. The material consisted of a series of 27 duplicate samples from routine autopsy cases comprising mainly drug addicts. A chiral LC-MS/MS method was used for measurement of the R- and S-enantiomers of methadone and its main metabolite 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP). The analytical CV% was determined to be in the range 3-4% for methadone enantiomers and 4-6% for EDDP enantiomers. The total measurement uncertainty (CV(T)) was estimated from the pre-analytical variation (CV(PA)), analytical variation proper (CV(A)), and variation related to calibration (traceability) (CV(Cal)) according to the relationship CV(T) = [CV(2)(PA) + CV(2)(A) + CV(2)(cal)](0.5). Uncertainty related to calibration concerned a component related to the purity of drug reference compound and a contribution from the production of calibrator solutions (CV(Cal)<1%). Pre-analytical sampling variation was estimated from the duplicate measurements of blood samples after subtraction of the analytical component. The pre-analytical variation amounted to a CV% of 19-21% for R- and S-methadone and 30-38% for R- and S-EDDP, i.e. considerably larger than the other components. Due to the squared addition principle, the resulting total uncertainty (CV(T)) became largely identical to the CV(PA), i.e. 19-21% for R- and S-methadone and 31-38% for R- and S-EDDP enantiomers. Accordingly, CV(T) exceeded CV(A) by a factor 5 or more. Dominance of the pre-analytical component of variation may also be likely for other compounds measured in postmortem blood samples. Thus, the width of the 95%-uncertainty interval (+/-2CV(T)) for a postmortem measurement is largely determined by the pre-analytical component of variation. This should be kept in mind when judging on the uncertainty of postmortem measurement results. 相似文献
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