Postmortem redistribution of fentanyl in the rabbit blood

Postmortem redistribution of fentanyl in the rabbit was investigated after application of the 50-μg/h Durogesic pain patch. Patches were applied for 48 hours. Two cycles of patch administration were used before characterization of the postmortem redistribution. Fentanyl showed marked redistribution into the femoral and pulmonary veins of the rabbit through 48 hours after the animals were humanely killed and the pain patches removed. The plasma concentration of 2.34 ng/mL in the femoral blood before killing the animals increased 5.6-fold by 48 hours after patch removal to 13.2 ng/mL. This postmortem concentration is approximately 3-fold the C(max) determined during antemortem pharmacokinetic analysis, 4 ng/mL, which was achieved 24 hours after the application of the second 50-μg/h Durogesic pain patch. After blood sampling for 48 hours after animal termination with patch removal compared with sampling for 48 hours from animals not terminated and with patch removal, the exposure ratios in the terminated animals were approximately 30-fold, indicating that between the postmortem redistribution of fentanyl and the cessation of hepatic clearance of fentanyl in the rabbit, the postmortem redistribution of fentanyl leads to an elevated measures of postmortem blood concentrations relative to antemortem blood concentrations.     

Psychopathy and predatory violence in homicide,violent, and sexual offences: Factor and facet relations

Purpose. Evidence has been found pointing to a relationship between psychopathy and predatory violence. The present study investigated the violence mode and its relationship with psychopathy on factor as well as on facet levels. It was hypothesized that predatory violence would be related to the affective and/or interpersonal facets of psychopathy. A subsidiary hypothesis was that sexual offences could also be differentiated by means of violence mode. Methods. Participants were 82 male inmates convicted of a violent crime, a sexual crime, or a homicide. Psychopathy was assessed with the Hare PCL‐R2 and the violence mode was assessed by means of Cornell's Aggressive Incident Coding Sheet, based on interviews with the offenders and a review of the official record. Results. On the psychopathy subcomponent level, only the interpersonal facet was positively related with predatory violence. This association makes sense considering that psychopaths' interactions with others are defined by gradients of power and control and narcissistic gratification, rather than by attachment patterns. By contrast, the antisocial facet was associated negatively with predatory violence. Our subsidiary hypothesis concerning the possibility of differentiating sexual violence on the basis of the two violence modes was not confirmed. Conclusions. The present results add to the growing evidence that predatory violence is related to the personality traits of psychopathy rather than to its life‐style and antisocial characteristics. Therefore, a risk analysis of future predatory violent behaviour might benefit from the inclusion of the assessment of the personality facets of psychopathy instead of focusing solely on the antisocial behaviour.     

Suicide with a manipulated hand grenade

Explosion injuries in civilians are rare. An uncommon case of suicide with a manipulated hand grenade is presented. The findings at the scene and on the body (i.a. massive soot blackening of the skin, singeing, size and number of splinters) gave reason to doubt the use of trinitrotoluene (TNT), the usual explosive charge in hand grenades. Further investigations showed that parts of several hand grenades and black powder from standard fire-crackers commercially available without legal restriction had been used as propelling charge. The victim, who was in a sitting position, held the hand grenade in the left hand and triggered it with the right. He bled to death due to a fracture of the right femur and lacerations of the liver. The chronological course and total circumstances of the case suggested suicide in a strongly intoxicated condition (BAC 2.5 per mille). In the flat, a larger number of unlicensed weapons and weapon parts were found.     

Trotz Art 6 MRK keine mündliche Verhandlung bei Aufhebung einer einstweiligen Verfügung, wenn nur Rechtsfragen und "technische Fragen" zu klären sind

Ist Verfahrensgegenstand eine einstweilige Verfügung nach § 382b EO, liegt eine Entscheidung über "civil rights" vor. Somit ist Art 6 MRK auch im Provisorialverfahren anwendbar. Die Aufhebung einer einstweiligen Verfügung erfordert trotz Art 6 MRK keine mündliche Verhandlung, wenn bei unstrittigem Sachverhalt lediglich Rechtsfragen oder in hohem Ma? technische Fragen zu kl?ren sind. Die blo?e ?nderung der Beweislage bildet keinen Grund für die Aufhebung einer einstweiligen Verfügung. Die analoge Anwendung der Vorschriften der ZPO über die Wiederaufnahmsklage ist im Provisorialverfahren nicht vorgesehen.     

Swedish legal scholarship concerning protection of vulnerable groups: Therapeutic and proactive dimensions

This paper presents a brief overview of the legal theoretical problems that arise in connection with the societal ambition of protecting vulnerable groups. One of the central difficulties in legislation with proactive and therapeutic ambitions arises from the link between law and philosophy of science, i.e., the relationship between facts and norms. It is shown that Therapeutic Jurisprudence differs in several aspects from Swedish legal scholarship that follows Scandinavian Legal Realism. It is also demonstrated that Therapeutic Jurisprudence has several similarities with the so-called Proactive Approach. This paper suggests that Therapeutic Jurisprudence may serve as a useful legal theoretical perspective in Swedish legal scholarship, especially when studying complex and vague regulations with a future focus. Two examples from Swedish legislation are examined: (a) Laws regulating compulsory care of abused or neglected children, and (b) laws related to the mentally ill. This paper illustrates the complexity in these acts, and poses the question of whether the regulations serve their purpose of providing adequate care for and protection of those in need.     

Explaining health care system change: problem pressure and the emergence of "hybrid" health care systems

In this article, we will further the explanation of the state's changing role in health care systems belonging to the Organisation for Economic Cooperation and Development (OECD). We build on our analysis of twenty-three OECD countries, which reveals broad trends regarding governments' role in financing, service provision, and regulation. In particular, we identified increasing similarities between the three system types we delineate as National Health Service (NHS), social health insurance, and private health insurance systems. We argue that the specific health care system type is an essential contributor to these changes. We highlight that health care systems tend to feature specific, type-related deficiencies, which cannot be solved by routine mechanisms. As a consequence, non-system-specific elements and innovative policies are implemented, which leads to the emergence of "hybrid" systems and indicates a trend toward convergence, or increasing similarities. We elaborate this hypothesis in two steps. First, we describe system-specific deficits of each health care system type and provide an overview of major adaptive responses to these deficits. The adaptive responses can be considered as non-system-specific interventions that broaden the portfolio of regulatory policies. Second, we examine diagnosis-related groups (DRGs) as a common approach for financing hospitals efficiently, which are nevertheless shaped by type-specific deficiencies and reform requirements. In the United States' private insurance system, DRGs are mainly used as a means of hierarchical cost control, while their implementation in the English NHS system is to increase productivity of hospital services. In the German social health insurance system, DRGs support competition as a means to control self-regulated providers. Thus, DRGs contribute to the hybridization of health care systems because they tend to strengthen coordination mechanisms that were less developed in the existing health care systems.     

Regional parliaments questioning EU affairs

ABSTRACT

Since the Treaty of Lisbon, the desire of parliaments to adapt to their new powers has led to a new wave of Europeanisation. However, the early warning system (EWS) and the political dialogue with the Commission constitute only a small part of parliamentary scrutiny for regional parliaments, which still largely rely on traditional tools such as mandates, debates and questions. Therefore, this paper studies a traditional mechanism of scrutiny, parliamentary questions, in order to understand how they can be used in an EU context. The study shows that Europeanisation is progressing slowly. Interestingly, the vast majority of MPs who ask EU-related questions are not members of the European Affairs Committee. In addition, questions focus primarily on the implementation stage rather than the policy-making stage. Finally, the content of parliamentary questions shows that regional parliaments have a distinctive territorial approach to EU affairs.     

Conclusion: regional parliaments – a distinct role in the EU?

ABSTRACT

Regional parliaments can shape EU policy-making via a range of domestic and European channels. In the context of a renewed interest in the subnational level, this article aims to address three core questions: have regional parliaments really been empowered by the early warning system provisions? Which factors explain differences in strength and mobilisation? Finally, what kind of a role do regional parliaments play in EU policy-making today, now that they have had several years to react to the trend towards multilevel parliamentarism? The authors argue that regional parliaments do indeed have the potential to contribute a distinct perspective to EU policy-making, even if their current level of activity is still low. Their distinctive territorial focus sets them apart from national parliaments. Their level of activity still varies greatly between parliaments depending on a number of factors.     

Governing Morality Issues through Procedural Policies

Abstract: Morality issues such as the death penalty, drug consumption, gambling, and same‐sex‐marriage often constitute intractable policy controversies. Classical “morality politics” scholars predict two types of governmental responses to such public problems: either a substantive policy design if there is a broad consensus among electoral constituencies or a non‐decision if there is a fundamental clash of values. We argue that the adoption of a procedural policy design represents a third option. Providing empirical evidence on the plausibility of this hypothesis, we compare the Swiss regulation of four morality issues in the medical field: reproductive medicine and embryo‐related research; abortion; euthanasia; and organ transplant. In fact, “moral values” frames are not always dominant, as the multi‐dimensionality of each morality issue allows for concurrent policy frames promoted by various policy actors.