The determination of lysergide (LSD) in urine by high-performance liquid chromatography-isotope dilution mass spectrometry (IDMS)

The use of isotope dilution mass spectrometry (IDMS) has been investigated for the forensic confirmation of lysergic acid diethylamide (LSD) in urine by LC-MS. The advantages of using a deuterated analog of LSD as an internal standard over methysergide are discussed. This study includes a comparison of the electrospray mass spectra of LSD, LSD-d3 and methysergide, and discusses the choice of suitable ions for use in selected ion monitoring (SIM) mode. An IDMS method is presented for the LC-MS confirmation of LSD in urine, with a limit of quantification (LOQ) of 0.5 ng/mL, reflecting the forensic requirement at this laboratory. Under some circumstances the LOQ can be improved to 0.1 ng/mL. This method is linear in the range tested (up to 10 ng/mL LSD in urine) and has been validated in terms of accuracy and precision.     

The dominant male [letter

I must agree with Ms. Taylor's conclusion that "a couple's equality in bed is likely to reflect their social and economic equality" (Sex and the 3rd world woman, June issue). My discomfort with the article arose partly from being among the mass of male sexual oppressors, but mainly from the shallowness of her report (more rhetoric than reporting). It may satisfy an appetite for feminist literature but let us think more clearly. What % of 3rd world women actually have their sexual organs tampered with? Female circumcision in Kenya, for instance, traditionally had nothing to do with this. Opportunities for women are fewest in strict Muslim societies. Ms. Taylor narrow-mindedly expects us to believe that this is entirely due to the dominant male. New Internationalist should reconsider publishing articles with so little substance as they will not aid in any real understanding of the fate of women in the 3rd world.     

Policy reforms in sub-Saharan Africa: Conditions for establishing a dialogue

Third World debt continues to be a critical and intractable issue. A particularly interesting aspect of the story is the effort by external donors and lenders to promote specific policy changes in exchange for assistance in dealing with indebtedness and promoting economic development. This study looks at the interactions between donors and decision-makers in sub-Saharan African countries, an area where donors rather than private banks play a dominant role. Donors have been learning from the uneven response to the reforms and are attempting to tailor the reforms somewhat to different contexts and to encourage more consultations. To succeed in these efforts they need to reexamine their view of analysis as a purely technocratic exercise among experts. They can learn from recent changes in the policy sciences, here called an interactive approach to policy analysis. It makes three assumptions: policy relevant knowledge includes time and space information and is diffused; participants can reason together and learn from each other; and there is a need for procedures and institutions to facilitate interaction and learning. The study explores the assumptions implicit in donor actions and proposes that an interactive approach, with its more open-ended perspective on knowledge, can stimulate greater dialogue and expand the kinds of information that are fed into the process. Louise G. White is associate professor in the department of public affairs at George Mason University, Fairfax VA 22030–4444. Her research is in the general areas of development management and policy analysis. Her most recent books areCreating Opportunities for Change: Approaches for Managing Development Programs, andPolitical Analysis: Technique and Practice. She has recently published articles inPublic Administration Review andWorld Development.