Chemical fingerprinting of adhesive tapes by GCMS detection of petroleum hydrocarbon products

Pressure-sensitive adhesive tapes often represent key evidence of crimes such as assault, rape or homicide; thus, the development of analytical techniques able to contribute to a detailed characterization of these materials is of forensic importance. The gas chromatography-mass spectrometry (GCMS) analysis of the solvent extractable fractions of a suite of electrical and gaffer adhesive tapes spanning a range of colors and manufacturers identified a number of petroleum-derived hydrocarbons. Molecular and isotopic analyses of hydrocarbon constituents of complex materials have found wide analytical utility including the forensic investigation of oil spills and arson. Here, we investigate the utility of these techniques for characterizing the hydrocarbon composition of pressure-sensitive adhesive tapes for forensic correlation purposes. Subtle distinction of tape samples was evident in the GCMS distribution of several hydrocarbon groups including alkyl-naphthalenes, hopane and sterane biomarkers. Linear discriminant analysis of the abundances of these products provided high level differentiation of tape manufacturer. The distinction of different adhesive tape samples was further extended by measurement of their stable carbon isotopic values. The molecular and isotopic differences of the petroleum content of tapes are consistent with the use of different petroleum materials used in the manufacturing process and demonstrate the benefits of the combined use of complementary oil hydrocarbon characterization approaches. This study reveals the forensic potential of using established petroleum characterization methods for characterizing materials with a petroleum-derived hydrocarbon element.     

Deliberative layering: Explaining diverse interest mobilization across the European Parliament's Policy Cycle

Drawing from work on deliberation and information‐access, this paper conceptually frames why and when different types of interests mobilize across the parliamentary policy cycle. We posit that each policy stage holds its own deliberative purpose and logic, leading to a variation in the type and volume of information demanded. The legitimacy of the expertise interest groups provide is affected by their organizational characteristics. To ensure the smooth flow of the policy process, members of parliament encourage groups that legitimately hold relevant information to mobilize at each policy stage, while lobbyists choose to mobilize when their expertise allows them to better influence policy‐makers' debates. We test our argument in the context of the European Parliament, following a unique survey of the 8th legislature (2014–2019). The responses lend support to our model. In a policy process that contains various stages of deliberation, different organizations hold an information‐expertise key that gives them access at different stages. Significantly, less studied groups, such as think tanks and consultancies, mobilize well ahead of others in the cycle's initial phases; while lobbyists representing public constituencies dominate in the final stages. The paper contributes to broader theoretical discussions on pluralism, bias, and deliberation in policy‐making.     

Prospects for health impact assessment in the United States: new and improved environmental impact assessment or something different?

Health impact assessment (HIA) has been advanced as a means of bringing potential health impacts to the attention of policy makers, particularly in sectors where health impacts may not otherwise be considered. This article examines lessons for HIA in the United States from the related and relatively well-developed field of environmental impact assessment (EIA). We reviewed the EIA literature and conducted twenty phone interviews with EIA professionals. Successes of EIA cited by respondents included integration of environmental goals into decision making, improved planning, and greater transparency and public involvement. Reported shortcomings included the length and complexity of EIA documents, limited and adversarial public participation, and an emphasis on procedure over substance. Presently, EIAs consider few, if any, health outcomes. Respondents differed on the prospects for HIA. Most agreed that HIA could contribute to EIA in several areas, including assessment of cumulative impacts and impacts to environmental justice. Reasons given for not incorporating HIA into EIA were uncertainties about interpreting estimated health impacts, that EIA documents would become even longer and more complicated, and that HIA would gain little from the procedural and legal emphasis in EIA. We conclude that for HIA to advance, whether as part of or separate from EIA, well-formulated methodologies need to be developed and tested in real-world situations. When possible, HIA should build on the methods that have been utilized successfully in EIA. The most fruitful avenue is demonstration projects that test, refine, and demonstrate different methods and models to maximize their utility and acceptance.     

Doping control analysis of selected peptide hormones using LC-MS(/MS)

With the constantly increasing sensitivity and robustness of liquid chromatography-mass spectrometry-based instruments combined with enhanced reproducibility as well as mass accuracy and resolution, LC-MS(/MS) has become an integral part of sports drug testing programs particularly concerning the detection of peptide hormones. Although several of the relevant peptidic drugs such as insulins (Humalog LisPro, Novolog Aspart, etc.), growth hormone releasing peptides (GHRPs, e.g., GHRP-2, GHRP-6, Hexarelin, etc.), and insulin-like growth factors (e.g., IGF-1, IGF-2, long-R(3)-IGF-1) are currently analyzed using dedicated top-down analytical procedures, i.e. employing specifically tailored sample preparation procedures followed by targeted LC-MS(/MS) measurements focusing on intact analytes, first approaches towards multi-analyte methods have been established. These allow the determination of the prohibited substances in blood and urine doping control specimens following therapeutic applications. In addition, the use of new complementary devices such as ion mobility analyzers, e.g., in hybrid mass spectrometers yielded promising data for the differentiation of isobaric insulins, which outlines the potential to further accelerate and multiplex doping control analytical assays to meet the continuously increasing demands of rapid and unambiguous test methods. Moreover, the potential of LC-MS/MS to target recombinant peptide hormones such as human growth hormone using bottom-up approaches has been demonstrated by targeting proteotypic peptides that unambiguously differentiate the recombinant molecule from the naturally occurring and endogenously produced analog.