Vascular lesions in intestinal ischemia induced by cocaine-alcohol abuse: report of a fatal case due to overdose

Intestinal ischemia induced by cocaine abuse is a rare condition. To this date, only three cases have been described. The diagnosis of bowel ischemia should be suspected whenever a cocaine addict has severe abdominal pain. A pathological examination of the resected bowel segment was performed in one case, and the diagnosis was confirmed microscopically. However, the existence of pathologic alterations of the intestinal vessels was not confirmed. Why the intestinal injury is segmental and whether it is related to the dose ingested, the administration route, or the combination of cocaine with alcohol, caffeine, or marijuana remain unclear. The authors report one fatal case associated with cocaine-alcohol overdose. The postmortem examination demonstrated the existence of segmental intestinal ischemia. Microscopic study failed to demonstrate thrombosis in the mesenteric vessels; however, we found an unusual lesion affecting the arterioles located in the intestinal submucosa of the hemorrhagic areas.     

Are inputs sometimes outcomes? Some thoughts on definition in distributive justice

This paper argues that the central concepts of justice theory (e.g., inputs and outcomes) have not been well defined and that this lack of precision in definition has led to subsequent ostensible inconsistencies in empirical findings. We offer definitions of both inputs and outcomes in a manner that facilitates more formal theoretical formulations and specifies a functional relationship between the two. In addition, the concept of relevance is discussed. This discussion highlights the difference in determinations of what is relevant to an outcome and the moral desirability of the distribution rule producing those outcomes. We suggest that the perception of what is relevant to the production of an outcome and how much it should be weighted is a source of potential conflict and/or disagreement between groups who are allocators or recipients of resource distributions. The potential disjuncture between what is considered relevant and what is considered moral in terms of allocation decisions is a potential source of dissatisfaction and feelings of injustice across groups. The discussion also suggests that it is not simply a difference in rule preference across groups that may lead to negative feelings regarding allocations but even when groups agree on the rule they may not agree on either the factors to be included in the assessment of relevance or on the morality of the distribution resulting from such assessments. Finally we introduce the concept of exchange domain as a mechanism for facilitating theoretical development.     

Isoelectric focusing studies on the PGM1 subtypes in the northern Japanese population

The distribution of the human red cell phosphoglucomutase (PGM1) subtypes in samples from Japanese population (n = 277) living in the Miyagi Prefecture, the northern part of Japan, was investigated by applying the thinlayer polyacrylamide gel isoelectric focusing. In our population sample all the ten common phenotypes were demonstrated, and the estimated allele frequencies for the genes PGM1+1, PGM1-1, PGM2+1, and PGM2-1 were 0.671, 0.107, 0.161, and 0.061, respectively. Family studies (n = 40) indicated an autosomal codominant inheritance and confirmed the four alleles. The new system will increase the probability of exclusion in paternity cases among Japanese to 29.4% compared with 14.3% if the two allele system is used.     

A fatal case of oral ingestion of toluene

A 51-year-old male ingested orally a large quantity of toluene and died about 30 min later. The presence of toluene in body fluids and tissues was confirmed by gas chromatography and gas chromatography/mass spectrometry. Tissue distribution of toluene showed that the liver detected the highest content of toluene (433.5 micrograms/g), except for the stomach contents, followed by pancreas (88.2 micrograms/g), brain (85.3 micrograms/g), heart (62.6 micrograms/g), blood (27.6 micrograms/g), fat (12.2 micrograms/g) and finally cerebrospinal fluid (11.1 micrograms/g).