There is strong evidence that chronic, systemic inflammation hastens onset of the diseases of old age that ultimately lead to death. Importantly, several studies suggest that childhood adversity predicts chronic inflammation. Unfortunately, this research has been plagued by retrospective reports of childhood adversity, an absence of controls for adult stressors, and a failure to investigate various competing models of the link between childhood adversity and chronic inflammation. The present study was designed to address these limitations. Using 18 years of data collected from 413 African Americans (58% female) included in the Family and Community Health Study, hierarchical regression analyses provided support for a nuanced early life sensitivity explanation for the link between early adversity and adult chronic inflammation. Controlling for health risk behaviors and adult SES, late childhood (ages 10–12) adversity amplified the association between adult adversity (age 29) and chronic inflammation. This interaction operated in a domain-specific fashion. Harsh parenting amplified the relation between intimate partner hostility and inflammation, whereas early discrimination amplified the relation between adult discrimination and inflammation. These findings suggest that individuals may be primed to respond physiologically to adverse adult circumstances that resemble those experienced earlier in life.
Proponents of a wide range of power transition theories suggest that conflict between the United States and China is inevitable. History indicates that is not true and conflict can be deterred. A key element to that deterrence is an effective Alliance strategy. While the Obama Administration has outlined an effective deterrent national strategy, it has not provided any military strategy. Some have proposed Air Sea Battle can be that strategy. For a variety of reasons, ASB will not work. This article proposes the Alliance adopt Offshore Control as a military strategy to deter China and assure allies and friends in the region. It is based on the concept of defending the first island chain, denying China use of the seas inside the first island chain and dominating the seas outside it. Its deterrent power is enhanced because Offshore Control is affordable, politically feasible, and can be executed today. 相似文献