甲基苯丙胺在豚鼠毛发中分布及转化的初步研究

目的对甲基苯丙胺在豚鼠毛发中分布及转化机制进行初步研究。方法利用GC/MS,GC/NPD法,测定单次及多次给药豚鼠毛发中MAP、AP的含量变化过程,考察给药剂量与毛发中MAP、AP的含量间的关系,并研究毛发颜色对染毒豚鼠毛发中MAP、AP含量的影响。结果单次及多次给药豚鼠毛发中代谢产物AP均高于原体MAP,给药时间及给药剂量与毛发中MAP、AP的含量显著相关,同体豚鼠黑色毛发中的MAP、AP含量均明显高于棕色、白色毛发。结论给药方式、给药剂量及毛发颜色对豚鼠毛发中MAP、AP的含量均有显著影响。     

Y-chromosome haplotype analysis in Antioquia (Colombia)

Allele frequencies and haplotype analysis have been performed for eight Y-chromosome STRs (DYS19, DYS385 I and II, DYS389 I and II, DYS390, DYS391, DYS392, DYS393). Population data was obtained from a sample of 400 unrelated individuals living in Antioquia (Colombia). A total of 270 different haplotypes were found, and the haplotype diversity was 0.989. The first and second most frequent haplotypes where shared by 8 and 6% of the individuals, respectively.     

Identification of firearms holders by the [Fe(PDT)3](+2) complex. Quantitative determination of iron transfer to the hand and its dependence on palmar moisture levels

Quantitative data are reported for the first time on the amounts of iron, which are transferred to the hand upon holding a firearm. Iron levels between 21-315 ng/cm2 were found on volunteers' palms after a single holding of a handgun. Determination of the iron traces was accomplished spectrophotometrically using 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine (PDT) as a complexing agent. The transfer of iron from firearms to the palm was found to be, by and large a chemical (dissolution) rather than mechanical dislodgement. The prime factor that determines the amount of iron transferred from the firearm to the hand is the moisture level on the palm. These findings are likely to be of importance in courts of law, as well as in the war against terrorism and serious crime.     

Mapping the Genome of American Political Subcultures: A Proposed Methodology and Pilot Study

The landmark work of Daniel Elazar spawned a generation of researchsuggesting that regional subcultures produce consequences forpolitical behavior, governance, and representation across theUnited States. However, little attention has been paid to directlymeasuring the degree to which citizens living in particularcommunities actually share particular value orientations thatdiffer markedly from those of citizens living in other communitiesand whether such differences are consistent with Elazar's theory.This article proposes a research program devoted to these questions,offers a methodology designed to address them, and describesa pilot study to that effect. Although Elazar's framework standsup to empirical scrutiny in some important respects, a thoroughreexamination is in order.     

Body Dissatisfaction and Physical Development Among Ethnic Minority Adolescents

The present study examined the association between body dissatisfaction and adjustment, and the role physical development plays in this association, in an ethnically diverse sample of over 1100 urban, ninth grade boys and girls (M age = 14). More similarities than differences were found across ethnic groups: Caucasian, African American, Latino, Asian, and multiethnic boys reported similar areas of body dissatisfaction, levels of body dissatisfaction, and associations between body dissatisfaction and psychosocial maladjustment. For girls, only mean level differences were found with African American girls reporting lower levels of body dissatisfaction than girls from other ethnic backgrounds. Higher levels of body dissatisfaction predicted more psychological and social maladjustment for both boys and girls. For boys, faster development predicted stronger associations between feeling overweight and peer victimization. Feeling too small only predicted victimization if boys were actually low in physical development. For girls, physical development directly predicted less peer victimization, while perceived faster development predicted more victimization. Thus, it appears that physical development can protect both girls (directly) and boys (buffering against the negative effects of body dissatisfaction) from peer victimization, whereas perceived faster timing of development can exacerbate peer victimization.Adrienne Nishina conducted this research as an NIH postdoctoral fellow in the UCLA Department of Education. She is currently an Assistant Professor in the Department of Human and Community Development at UC Davis. She received her PhD in clinical psychology from UCLA. Her major research interests include mental health in schools, adolescent peer relations, and ethnic diversity.Natalie Y. Ammon is a graduate student in the Department of Human Development and Family Sciences at the University of Texas, Austin. Her major research interests are at-risk youth and academic achievement.Amy D. Bellmore is an American Psychological Association/Institute of Educational Sciences Postdoctoral Education Research Training fellow at the University of California, Los Angeles. She received her PhD in developmental psychology from the University of Connecticut. Her research interests include peer-directed aggression, ethnicity and ethnic contexts, and the development of interpersonal perception.Sandra Graham is a Professor in the Department of Education at the University of California, Los Angeles. She received her PhD degree in educational psychology from UCLA. Her major research interests are the academic motivation and social behavior of ethnically diverse adolescents in urban schools.