Synthesis of 2,3- and 3,4-methylenedioxyphenylalkylamines and their regioisomeric differentiation by mass spectral analysis using GC-MS-MS

3,4-methylenedioxyamphetamine (MDA) derivatives are increasingly abused central nervous system stimulants with neurotoxic properties. In recent years a number of controlled substance analogs (designer drugs) with high structural variety reached the illegal market making their identification an arduous task. The underivatized compounds give very similar or even virtually identical electron impact mass spectra containing mainly intense C(n)H(2n+2)N(+) immonium ions. Using tandem mass spectrometry (MS-MS) the additional structural information contained in the collision induced dissoziation (CID) mass spectra of molecular ions using electron impact (EI) and especially chemical ionization (CI) allowed an unequivocal differentiation of 18 studied regioisomeric 1-(methylenedioxyphenyl)-2-propanamines and 1-(methylenedioxyphenyl)-2-butanamines.Further synthetic methods are presented for 1-(3,4-methylenedioxyphenyl)-N-propyl-2-butanamine, N-isopropyl-1-(3,4-methylenedioxyphenyl)-2-butanamine and four 1-(2, 3-methylenedioxyphenyl)-2-butanamines. N-alkylated 1-(3, 4-methylenedioxyphenyl)-2-butanamine compounds (e.g. MBDB) are also known to be abused psychoactive agents (entactogenes) without the sympatomimetic effects of the 3,4-methylenedioxyamphetamines.     

Black and white identity development: Aspects and perspectives

Empirical definitions of identity formation, and five variants, were constructed using a technique for studying multiple self-images. The method was then applied to a sample of black and white lower socioeconomic class boys. These boys were tested with this technique and given in-depth interviews twice a year, from the start to the finish of high school. The results of these longitudinal studies disclose that the black and white adolescents have emphatically differentpatterns of identity formation. The blacks are characterized by unchanging configurations of self-images. Both the content of their self-definitions and the interrelations for these self-definitions remain strikingly stable over the years. The whites, on the other hand, display a progressive integration of different self-images and stabilization of the content of these images. The more qualitative interview data corroborate these quantitative findings. The patterns displayed by the blacks are consistent with the definition of identity foreclosure, a disruption in ego identity development. The whites' patterns, however, are consistent with progressive identity formation. In addition to discussing these results, the paper goes on to consider ways to understand the findings. Sociocultural as well as cognitive aspects of the racial differences in identity development are explored.This is a revised version of a presentation to the Fall Meeting of the American Psychoanalytical Association, December 16, 1970. The earlier version was also the recipient of the Harry C. Solomon Essay Prize at the Massachusetts Mental Health Center, June 1970.Received M.A. (Social Anthropology) from Harvard University and M.D. from Yale University. Currently studying self-image and cognitive development in populations of normal and psychiatrically impaired adolescents.     

The body global and the body traditional: a digital ethnography of Instagram and nationalism in Kazakhstan and Russia

ABSTRACT

What is the power of social media in defining and policing sexual identities and bodily expressions, and what are their connections to understanding nation, power and self in authoritarian contexts? Through the study of popular Instagram accounts in Kazakhstan and Russia, I argue that these sites serve as spaces of visualization and re-creation of new forms of ‘acceptable’ behaviour and lifestyles, that on the one hand may lead to new globalized visions of sexual identity and the body while on the other promoting localized conflict and resentment online, triggered by online users’ fear of losing their ‘national culture’ in these global trends. While many resort to policing gender norms and heteronormative body images online, influencers and Instagrammers from Russia and Kazakhstan take an active part in resisting these frameworks and categories.     

The determinants of the choice between public and private production of a publicly funded service

The public choice literature contains little formal analysis of the bureaucratic choice of production modes — public or private — of publicly funded services. An important question to be addressed is why some governmental bodies choose to provide a publicly funded service with publicly owned and operated production units whereas other governmental bodies contract with private firms to provide the same publicly funded service. This paper is the first formal attempt to remedy this gap in the literature. We develop a theoretical explanation of the government decision maker's choice between public and private production modes based on utility maximizing behavior. We then examine empirically this choice employing logit analysis. The empirical results, which include several tests for robustness, confirm our theoretical explanation. The results are significant and suggest that non-monetary constraints are an important factor affecting this choice of production modes and that monetary constraints are less influential.