Simultaneous analysis of d-3-methoxy-17-methylmorphinan and l-3-methoxy-17-methylmorphinan by high pressure liquid chromatography equipped with PDA

d-3-Methoxy-17-methylmorphinan (Dextromethorphan, DXM), which is a structural analog of morphine and codeine, has been widely used as a non-narcotic antitussive agent. It is a safe drug in therapeutic dose and does not produce analgesic effects, while its enantiomer, l-3-methoxy-17-methylmorphinan called levomethorphan (LXM) is a potent narcotic analgesic. DXM has been widely abused in Korea due to its hallucinogenic effect in large doses; therefore, the health authorities have regulated its use as a psychotropic agent since 2003. As its abuse has been serious, a possibility that DXM would be smuggled into Korea has also increased. Moreover, it has been suspected that there was the possibility of the adulteration or substitution of DXM with LXM due to their chemical similarities. Therefore, it was necessary for us to establish the enantiomeric separation of DXM and LXM. In this study, a liquid chromatographic method using a chiral column capable of separating stereoisomers of DXM as well as analyzing the major metabolites of DXM, 3-methoxymorphinan, 3-hydroxymorphinan, and 17-hydroxymethylmorphinan was developed. The validation of a method was studied through repeatability of retention times. Using this method, 32 confiscated DXM samples were analyzed to identify the enantiomers of DXM. As a result, DXM was detected in all samples and there was no evidence of the adulteration or substitution of DXM with LXM. Nevertheless, the stereochemical analysis of DXM and LXM is important not only to identify starting materials for illegal drug manufacture but also to understand the trends of abused drugs.     

Hyaluronidase as a liquefying agent for chemical analysis of vitreous fluid

Vitreous humor is a suitable specimen for postmortem clinical chemistry because the analytes remain relatively stable after death and they closely reflect blood levels immediately prior to death. The viscous nature of vitreous fluid, however, presents analytical problems including imprecision and inaccuracy. Various preanalytical treatments, such as boiling, high speed centrifugation, microfiltration and dilution have been used. These techniques are labor intensive and add to imprecision and inaccuracy. Because glycosaminoglycans contribute significantly to the viscosity of vitreous humor, we used hyaluronidase as a liquefying agent. We compared the results of analyses in 33 vitreous humor specimens after hyaluronidase treatment with the results after either no treatment or specimen dilution. Seventeen of the 33 specimens could not be analyzed without dilution. Even after dilution, several analytes still could not be measured. Hyaluronidase treatment negated the need for sample dilution and had no significant effect on the analyses.     

Barriers to competition and the effect on political shirking: 1953–1992

Economists and political scientists have offered a variety of explanations for why legislators might rationally choose to ignore the preferences of their constituents, political parties, and presidents. The broad conclusion of this literature is that there is an element of “shirking” in congressional voting. The objective of this paper is to suggest that the effects of shirking in congressional voting may have increased over time, largely in response to the raising of barriers to competition in congressional elections, thereby enabling legislators to vote their own preferences without fear of losing reelection. We use a quasi-experimental design that controls for the effects of party, region, electoral safety, presidential control of the White House, and constituency factors, in isolating the causal effects of barriers to entry on a continuous series of roll-calls regarding the raising of the debt limit between 1953 and 1992. We find that “shirking” in legislative voting on debt limit legislation is a post-1970s phenomenon.     

Justice, Democracy, and Hazardous Siting

In this essay we examine some issues of justice associated with the siting of hazardous industrial facilities. Utilitarian justifications of siting decisions are inadequate because they fail to address questions of fairness. Approaches that consider questions of distributive equity provide a better framework for siting justice, but are still incomplete. Limiting questions of justice to the distribution of benefits and burdens fails to examine the justice of procedures for deciding such issues of distribution. We argue that justice requires a participatory communicative democratic process for siting hazardous facilities, in two respects. It is prima facie unjust to impose a risk on citizens without their having participated in the siting process. Participatory communicative democratic procedures in facility siting, moreover, when structured according to specific norms of discussion and inclusion, are likely to yield the most just outcomes. We propose procedural as well as substantive conditions for such democratic procedures, and briefly apply these conditions to evaluate the siting of a landfill in Switzerland.     

18世纪的财产与刑罚:贝卡里亚及其批判者

贝卡里亚否认将财产视为自然或绝对的权利,但未正式提倡废除一切私有权。他指出个体欲望能促使每个人积极奋斗,并使财富在此过程中得以扩张,因此认为资源不平等在某种程度上是能够接受的。这种观点与《犯罪与刑罚》的主旨存在着潜在冲突：更为平等的财富和权力对他提倡的刑事司法制度形成至关重要。他的观点受到当时比他保守和激进的人的质疑和批评。保守主义者费尔迪南多·法基内认为等级社会中土地所有者的家族式统治应当得到刑法的维护和支撑。早期社会主义者艾伯·马布利则对贝卡里亚倡导的改革在充满竞争和不平等的资本主义社会的可行性表示怀疑。