SMART:自主研发的混合STR图谱分析系统

目的混合STR图谱的分析是法医遗传学领域的一个难题。目前国内大多数法医DNA实验室依靠人工方法分析混合STR图谱,费时费力,且拆分效果也多有主观性,难以满足日益增长的混合STR图谱分析的需求。本文介绍一套自主研发的混合STR图谱分析系统——SMART(STR Mixture Analysis and Resolution Tools),其能够实现对混合STR图谱的自动化分析,包括拆分混合STR图谱和计算似然比。方法SMART使用的STR峰高的概率模型,考虑了影子峰、降解、基因座特异性扩增效率、峰高变异、插入峰、峰丢失等因素。模型通过比较各个基因型集合拟合当前混合STR图谱的似然值大小来推断最有可能的基因型集合,采用了马尔可夫链蒙特卡洛(MCMC)算法进行求解。结果SMART可应用于不同试剂盒和遗传分析仪产生的数据。经使用ABI-3500XL遗传分析仪和Global Filer试剂盒测试,SMART能够实现对2~5人的混合STR图谱的分析,输出包括混合比例、混合图谱质量、各个贡献者单人的STR基因分型、似然比等多项结果。结论SMART作为一款自主研发的混合STR图谱分析系统,其基本涵盖了国外同类分析系统所具有的功能,技术性能指标达到国际先进水平,能够满足一线法医工作者对于混合STR图谱分析的多样化需求,提高混合STR图谱结果的利用率。     

全过程人民民主:时代价值、制度基础与实践空间

全过程人民民主是党的十八大以来我国社会主义民主政治发展的全新理论命题。全过程人民民主是中国共产党在百年未有之大变局下对人类政治文明新形态的实践探索,是推进国家治理现代化的现实逻辑,体现了中华民族伟大复兴中国梦的内在要求。在中国共产党的百年探索历程中,全过程人民民主有坚实的制度支撑、规范的运作机制、具体的程序设计,是最广泛、最真实、最管用的民主形态,既突出了中国社会主义民主政治发展的显著特色,也彰显了具体民主形式中所蕴含的人类共同价值。在新的历史起点推进全过程人民民主,要坚持党的领导、人民当家作主和依法治国的有机统一,在理想与现实、普遍性与特殊性、制度与实践的平衡中,适应人民群众对美好政治生活向往的需要,有目标、有步骤、有重点地积极推进。     

Is there a long‐run relationship between population growth and living standards? The case of India

This note examines the existence of a long‐run, cointegrating relationship between population and per capita GDP in India for 1950–93. Unit root tests show that per capita GDP is integrated of order one while population is integrated of order zero; further, estimation of the bi‐variate relationship using the cointegration procedure of Johansen shows that no long‐run relationship exists. Thus, population growth neither causes per capita income growth nor is caused by it. A corollary is that population growth neither stimulates per capita income growth nor detracts from it.     

Non‐tariff measures and United States' imports of CBERA‐eligible products

Trade coverage ratios are calculated to assess the 1991 incidence of non‐tariff measures (NTMs) on imports of products eligible for duty‐free treatment under the United States’ Caribbean Basin Economic Recovery Act (CBERA). Overall, 16 per cent of all CBERA‐eligible products were found to be covered by one or more NTM. Corresponding figures for all eligible products exported from individual beneficiaries range up to 40 per cent. Much higher trade coverage ratios are found for individual product groups. NTMs constitute important deterrents to US imports of CBERA‐eligible products. Heavy reliance on NTMs counters the intent of the CBERA, namely to extend preferential treatment to exports from Caribbean Basin countries.     

A critique of bourgeois theories of economic development

Festival expenditures amount to over 15 per cent of a household's annual expenditures in rural India. Yet they have never been studied by economists. This article uses both qualitative and quantitative data from a case study of three South Indian villages to show that festivals are important public goods in the village, but neither a pure entertainment motive nor an altruistic desire to contribute to a public event seems to explain their size. Households which spend money on festivals, everything else held equal, are able, however, to generate tangible rewards - lower prices on food, higher social status and more invitations to meals from other families. This indicates that active participation in festivals generates private economic and social returns which help resolve a potential free-rider problem. The evidence is consistent with the notion that festivals serve as mechanisms by which communities build social networks.     

The Things They Learned: Aspiration,Uncertainty, and Schooling in Rwanda’s Developmental State

The role of formal education in the reproduction of inequalities is well documented. Less clear is how this lens can be applied to a study of post-conflict state-building. The present study pairs policy analysis with student-centred ethnographic fieldwork to examine education policy in Rwanda. Since the end of the genocide, the government has staked its claim to legitimacy in delivering inclusive development. Its basic education policy is an entitlement programme with broad public support and designed to allow all children to attend primary and secondary school. Students found themselves caught up in a web of contradictions with important symbolic and material dimensions. They went to schools designed to improve access for the poor. But they were also poor schools, lacking in quality and associated with failure. The country’s switch from French to English was bound up in alliances of domestic power that further undermined effective teaching and learning. The basic education policy intended to highlight the government’s commitment to deliver development to all. But in absence of a sustained and effective strategy to improve quality, young people felt excluded from meaningful engagement in the education system. Whether the basic education policy constitutes inclusive development is therefore debatable.