超高效液相色谱-串联质谱法同时测定尿液中16种抗生素

目的 建立同时分析尿液中16种抗生素的超高效液相色谱-串联质谱(UPLC-MS、MS)方法.方法 以哌拉西林为内标.尿样中的目标化合物经Oasis HLB固相萃取柱富集、纯化,利用ZORBAX SB-C18色谱柱,以0.1%的甲酸溶液-乙腈为流动相经梯度洗脱分离,采用多反应监测(MRM)模式进行分析.结果各化合物的最低...     

道德教育中的四个"交往"层次

要摆脱道德教育的实效低靡,必须打破对"交往"问题的纯粹、完美的抽象论述,从理论与现实相结合的角度来区分出交往的四个层次.进而明确正确处理道德教育中的四种交往关系,肯定四个层次的相对稳定性及差异性是前提,     

“Flashburning” — Interpreting the presence of heat damage to a suspect's clothing and footwear in the investigation of fires

When volatile flammable vapours are released, they can mix with surrounding air and form a vapour cloud. Ignition of this fuel/air mixture will produce a flame front that will flash through the vapour. Items exposed to the flame front, including a suspect's clothing and footwear, may sustain superficial heat damage. At The Forensic Science Service Ltd this is referred to as flashburning. This paper describes the concept of flashburning, the laboratory methodology used to identify it and how an assessment on the overall distribution of that damage may allow a scientist to evaluate its evidential significance. Two anonymised casework examples are used to demonstrate how this information has been interpreted and used in evidence in United Kingdom courts of law.     

Expressions of IL -1α, IL -1β and IL -13 mRNA in Lung Tissue and Serum of Rats Drown in Fresh WaterCSCD

Objective: To detect the changes of (interleukin, IL)-1α, IL-1βand IL-13 mRNA in lung tissue and serum of drown rats, and to explore the potential value for the diagnosis of drowning in forensic practice. Methods: Eighteen SD rats were randomly divided into drowning group, blank control group and myocardial infarction group (as control group). The serum of right ventricular, the inferior lobe of right lung and the myocardium were taken from the rats in different groups. The expressions of IL- 1α, IL-1βand IL-13 mRNA in the lung tissue and the serum of right ventricular were detected by TaqMan probe method. Results: The expression differences of IL-1α, IL-1βand IL-13 mRNA in lung tissue between drowning group and blank control group, myocardial infarction group were not statistically significant (P>0.05). The expression of IL-1βand IL-13 mRNA in serum of right ventricular increased (P<0.05). The expression differences of IL-1α, IL-1βand IL-13 mRNA in serum between blank control group and myocardial infarction group were not statistically significant (P>0.05). Conclusion: The changes of cytokines IL-1βand IL-13 mRNA in the serum of right ventricular of drown rats are statistical significance, which are highly correlated with drowning. © 2018 by the Editorial Department of Journal of Forensic Medicine.     

新世纪西方国家绩效审计的创新机制

本文以西方主要国家审计署网站最新资料为研究样本,利用文本分析方法对西方国家绩效审计的创新机制进行理论识别与系统分析。西方国家绩效审计的机制创新在理念上有一种否定之否定的发展趋势,在范围方面积极寻求自我突破;西方国家审计部门在指标设计方面导入自我评估主体,由此引发的困境需要进行风险降维,同时,着力通过评估保障、评估类型、评估流程和评估主体等组织实施过程提升质量,显现创新追求。     

马克思的教育哲学及其当代意义

马克思的理论旨趣似乎集中于政治经济学批判,但其最终目的乃是为了人的自由全面发展,教育是实现这一目的的重要途径之一.马克思在现代资本主义语境中对教育进行了考察,并在充分揭示现代性弊端和现代社会“人的问题”的基础上,提出了以综合技术教育为主要内容的教育哲学.这种教育思想的目的是促进社会进步,强调人与社会的和谐发展和共同进步,强调教育面向大众,与生产劳动相结合.因此,它在现代教育的问题域、教育目的以及教育中人与社会关系等内容上均超越了传统的教育思想,是一种教育革命,其对当代中国特色社会主义宏观实践以及微观的教育教学都具有重要的指导意义.马克思的“教育革命”是建立在其哲学革命——实践唯物主义和唯物史观基础之上的.     

What Difference Do Polarisation Measures Make? An Application to China

In recent years there has been much discussion of the difference between inequality and polarisation. The vast literature on inequality is held to miss out key features of distributional change, which are better described as changes in polarisation. Axioms have been proposed which capture some of these differences, and measures of polarisation, as distinct from inequality, have been suggested. The theoretical distinctions proposed in this literature are indeed interesting. But do the newly proposed measures of polarisation give different results in comparing societies over time? We address these questions for China, where dramatic increases in inequality and polarisation have been much discussed in the literature. We find that, contrary to theoretical expectation, the new measures of polarisation do not generate very different results from the standard measures of inequality. The paper ends by considering a different approach to polarisation which might better conform to the policy concerns expressed in the specific context of China.     

Information Exchange,Headquarters Economy and Financial Centers Development: Shanghai,Beijing and Hong Kong

Over the past several years, China has consistently maintained economic growth and at the same time emerged as a new global giant in the international arena, despite the distractions caused by the global financial crisis, which was triggered by the US Sub-prime Mortgage Crisis of 2007 and the recent bond crisis that emerged in the European Union in 2011. Concurrent with China's growing interaction with the global economy and robust growth of its domestic economy, competition for the status of national and even international financial centers in the region has become fierce. This study focuses on a ‘local’ examination of internal conditions for the emergence and growth of Chinese financial centers over the next 10–20 years. Cities contending for the top slot in the roster of Chinese cities, like Beijing, Shanghai and Shenzhen, are striving to become international financial centers and are trying to compete with Hong Kong. This study investigates the development potentials, future prospects and division of functions between different financial centers within China regarding Hong Kong, Beijing and Shanghai, with special reference to the role of information and locations of MNCs' regional headquarters.     

近代日本医护队伍的发展

明治维新以后,日本大力发展医疗事业,创立了以西方医学为基础的近代医学教育和行政体系,培养了大批职业的医生、助产士和护士等医学人才。近代日本医护队伍的发展,提高了医护人员的社会地位和职业水平,推动了医学知识和卫生意识的传播和普及,为日本人口数量和质量的提高做出了卓越贡献。     

Primary study of vascular endothelial growth factor immunohistochemical staining in the diagnosis of early acute myocardial ischemia

The expression of vascular endothelial growth factor (VEGF) in the model of rat early acute myocardial ischemia was studied by Strept-Avidin-Biotin-Peroxidase Complex (SABC) immunohistochemical staining. After ligating the anterior descending branch of the left coronary artery, an initial rapid (30min) positive expression of VEGF in myocardial ischemic areas was observed, the intensity of positive expression of VEGF increased with the continuation of myocardial ischemia. After 5h infarction, the strongly positive myocytes of SABC-VEGF staining were predominantly limited to perimyocardial infarction areas. No positive expression of VEGF was found in the control group. These findings suggested that SABC-VEGF method could give a sensitive, specific, simple and objective morphologic evidence to the diagnosis of sudden cardiac death caused by acute early myocardial ischemia.