Diverse morphological lesions and serious arrhythmias with hemodynamic insults occur in the early myocardial contusion due to blunt impact in dogs

To investigate the morphology and hemodynamics of the early myocardial contusion, an animal model of cardiac contusion was established by impact to the precordial region at sternum at velocity of 10.0m/s with a mechanical elastic-cord propelled impactor in 19 dogs. The electrocardiogram and both the left and right intra-ventricular pressures were recorded continuously throughout the experiment. Histological and immunohistochemical examinations of myoglobin, creatine kinase-MB and fibrinogen were conducted. At the moment of impact, abrupt over-pressures within the left and right ventricles occurred with concomitant serious arrhythmias followed by variety of cardiac conduction disorders and depressed left and right ventricular systolic pressures during the observation times. Histologically, lesions of myocardial contusions were identified at subepicardial, myocardial or subendocardial layer as interstitial hemorrhage, disruption or coagulative necrosis as well as contraction band necrosis of the muscle fibers, which might be categorized into the hemorrhagic, necrotized and mixed forms. The three forms of lesions were found to exist independently, or co-existed in a heart. However, severity of the lesions varied greatly with different parts even within a heart. Intravascular thromboses were occasionally discovered post-impact. Immunohistochemically, loss of myoglobin and creatine kinase-MB from cardiac cells, and accumulation of fibrinogen at the cell membranes were detected 5min post-impact. The intracellular accumulation of fibrinogen increased with extension of post-impact intervals. Our results indicate that diverse morphological lesions concomitant with hemodynamic compromise and serious, even fatal arrhythmias occur in the early myocardial contusion, and intravascular thromboses are occasionally produced, suggesting that traumatic myocardial ischemic lesion may be induced due to blunt impact to the precordial region.     

德法共治的理论可能、现实必然与实践路径

德法共治是新时代法治中国建设的重要维度。德治和法治具有可互补的差异性和可共存的一致性,使德法共治具有了理论层面的可能性。社会主义市场经济的双重规定、社会主义民主政治的双重内涵、社会主义文化建设的双重来源等因素使德法共治具有了现实层面的必然性。道德信仰与法律信仰的互通、道德功能与法律功能的互补、道德规范与法律规范的互化等共同构成了德法共治的实践路径。     

落实“两个普遍”深化“集中行动”在服务大局中彰显工会作为

推进“两个普遍”,发展和谐稳定新型劳动关系,是扩大覆盖面、增强凝聚力的现实需要.要争取更多资源和手段,构建联动工作格局,健全完善激励奖惩机制.坚持党建带工建、工建服务党建,以党工共建创先争优活动为综合载体.加强分类指导和培训,确保针对性和实效性.     

新型证券、期货犯罪若干问题

证券、期货犯罪案件具有数量不多、危害严重、以单位犯罪为主、手段多样、隐蔽性强和被害人具有无意识性和不特定性等特点。应当从本质上判断新型操纵证券、期货市场行为是否符合刑法规定。内幕交易、泄露内幕信息罪中内幕信息以及内幕信息敏感期的判断应当客观和准确。办理证券、期货犯罪案件是否需要作出违法行为行政认定的问题不可一概而论。证券、期货犯罪行为的证据标准应当结合相关司法解释进行把握。违规批露、不批露重要信息罪中损害结果应当以股票市值下跌量为依据。