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181.
A case is presented of a 54-year-old white female found dead in a secured apartment. Postmortem toxicologic analysis of the heart blood identified acetaminophen (97 mg/L), citalopram (0.4 mg/L), gabapentin (24 mg/L) and metaxalone (21 mg/L). The metaxalone concentration is within the range of previously reported fatalities involving metaxalone. The medical examiner ruled that the cause of death was metaxalone and gabapentin intoxication and the manner of death was suicide. 相似文献
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“Institutionalized science ethics” refers to the statutory, professional and institution-based ethical standards that guide
and constrain scientists' research work. The primary institution responsible for implementing institutionalized science ethics
is the Institutional Review Board. We examine the limitations of IRBs and institutionalized science ethics, using bureaucratic
theory and, especially, theory related to the development and enactment of rules. We suggest that due to the very character
of rules-based systems, improvements in IRB outcomes are unlikely to be achieved through either more or better rules or even
by bureaucratic reform. Instead, we suggest that improvements in human subject protection can best be advanced through increased
participation. Ours is not a call for more participation by the general public but participation, via “Participant Review
Boards” of persons who are eligible, by the protocols of the research in question, to serve as subjects. This provides a level
of legitimacy and face validity that cannot be obtained by IRB affiliates, even by “external representatives.” In making these
points, we review a recent science ethics controversy, the KKI/Johns Hopkins lead paint study. In spite of being approved
by IRBs, the study resulted in a civil lawsuit that reached the Maryland Court of Appeals. The case illustrates the limits
of institutionalized science ethics and the bureaucracies created for their enactment. The case also underscores the complex
and equivocal nature of the ethical guidelines established under the National Research Act.
We are grateful to – for providing helpful comments on an earlier draft. 相似文献
185.
In order to increase the understanding regarding the oral abuse and potential toxicity of fentanyl patches seven cases were identified over a 3-year period where fentanyl, either alone or in combination with other factors, contributed to death following the oral abuse of Duragesic patches. The decedents comprised three females and four males with ages ranging from 20 to 51 years. Postmortem blood fentanyl concentrations were determined in all cases and ranged from 7 to 97 ng/mL. Two deaths were classified as a fentanyl overdose, three deaths were classified as a fentanyl and ethanol overdose, one death was considered a mixed drug intoxication and the remaining death was determined to be a combination of fentanyl and medical causes. These cases represent the largest reported series of deaths following the oral administration of transdermal fentanyl patches and provide detailed information on the potential for the abuse of transdermal Duragesic patches via this route. The postmortem blood fentanyl concentrations detected for each of the decedents demonstrate the potentially fatal blood concentrations that can arise after this relatively rare route of administration. 相似文献
186.
The aims of this study were to verify if frontal sinuses can uniquely identify individuals belonging to family groups using Cameriere methods and to test if kinship can affect the proportion of erroneous identifications. For this purpose, we compared the proportion of false-positive identifications in a sample of 99 individuals within 20 families with a control sample of 98 other individuals without kinship. The results show that the combined use of SOR and the Yoshino code number allows personal identification with a small probability of false positives (p < 10(-6)), even when kinship is taken into account. The present research confirms the importance of studying anthropological frameworks for identification, which leads to reliable methods and allows for both quick and economic procedures. 相似文献
187.
This study examined the effectiveness of an abbreviated version of the Structured Interview of Reported Symptoms (SIRS-A)
in identifying malingered mental illness. The SIRS-A is comprised of 69 items drawn from the SIRS (R. Rogers et al. 1992,
SIRS: Structured Interview of Reported Symptoms: Professional Manual. Odessa, FL: Psychological Assessment Resources, Inc.), substantially reducing the administration time. A simulation design
was used with three samples; 87 psychiatric outpatients who responded honestly were compared to 29 community-dwelling adults
and 24 psychiatric patients instructed to malinger psychopathology. The SIRS-A generated sensitivity comparable to or exceeding
that of the SIRS normative data, but specificity was poorer; many genuinely impaired patients were misclassified as malingering.
Although these findings suggest the SIRS-A may be an effective means to assess malingering in psychiatric populations, further
research assessing the reasons for the elevated false positive rates is necessary. 相似文献
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Barry Markovsky 《Social Justice Research》1988,2(3):223-233
Central to equity and distributive justice theories is the assumption that reward inequities produce feelings of distress and that such feelings motivate efforts to reduce the perceived injustice. Physiological arousal under such conditions would provide direct evidence of injustice distress. To date, no such evidence exists. In the present study, a skin conductance measure was obtained for subjects receiving either just or unjust allocations in a pay-forwork setting. As expected, heightened arousal occurred (relative to baseline levels) in underpay and overpay conditions, with no such effect in a just-pay condition. It was also predicted and found that heart rate—more an index of somatic activity than distress—did not discriminate among experimental conditions. The implications of these results for theoretical development and applied research are discussed. 相似文献