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71.
72.
The Use of Laser Microdissection in Forensic Sexual Assault Casework: Pros and Cons Compared to Standard Methods 下载免费PDF全文
Sergio Costa M.Sc. Paulo Correia‐de‐Sá M.D. Ph.D. Maria J. Porto Ph.D. Laura Cainé Ph.D. 《Journal of forensic sciences》2017,62(4):998-1006
Sexual assault samples are among the most frequently analyzed in a forensic laboratory. These account for almost half of all samples processed routinely, and a large portion of these cases remain unsolved. These samples often pose problems to traditional analytic methods of identification because they consist most frequently of cell mixtures from at least two contributors: the victim (usually female) and the perpetrator (usually male). In this study, we propose the use of current preliminary testing for sperm detection in order to determine the chances of success when faced with samples which can be good candidates to undergo analysis with the laser microdissection technology. Also, we used laser microdissection technology to capture fluorescently stained cells of interest differentiated by gender. Collected materials were then used for DNA genotyping with commercially available amplification kits such as Minifiler, Identifiler Plus, NGM, and Y‐Filer. Both the methodology and the quality of the results were evaluated to assess the pros and cons of laser microdissection compared with standard methods. Overall, the combination of fluorescent staining combined with the Minifiler amplification kit provided the best results for autosomal markers, whereas the Y‐Filer kit returned the expected results regardless of the used method. 相似文献
73.
The first 150 words of the full text of this article appear below. Key points
1. Introduction
Scholarship describes professionals who participate in securitiesofferings, and who represent public companies in . . . [Full Text of this Article]
2. Background
3. Modelling law firm impact in IPOs
Theories of IPO pricing Relationship between pre-IPO price adjustment and diligence in legal services Extension of Hanley's model Conservative modelonly a portion of the impact is identified Issuer's counsel v underwriters counsel Confirming proper model specification Increased risk of an investment in the issuer affecting probability of engagement of quality law firm Different signs between issuer's lawyer and underwriters lawyer
4. Data
Summary statistics Measure of law firm prestige
- The article investigates the relationship betweenpricing in an initial public offering (IPO) and the prestigeof the participating underwriters law firm.
- The hypothesisof the article is that law firm quality affects how law firmsperform their obligations in IPOsmore prestigious lawfirms acting more independently. Consistent with this hypothesis,the authors find a negative relationship between pre-IPO priceadjustment and the participation of prestigious underwriterscounsel, and a negative relationship between the participationof prestigious underwriters counsel and initial return,which is consistent with market trading reflecting the decreasedrisk associated with offerings involving prestigious underwriterscounsel.
- Finally, it is found that certain observable characteristicsindicating diminished likelihood of undisclosed negative information(venture backing and quality of the issuer's counsel) are associatedwith an increased likelihood that prestigious underwriterscounsel is used.