TGF-β1在SCN5A基因变异所致心源性猝死中调控作用

SCN5A基因变异所致心源性猝死发生机制尚不清楚。目前研究显示TGF-β1介导心肌纤维化以及离子通道重构调节机制的异常可能是SCN5A基因变异导致SUNDS发生的主要原因。本文就转化生长因子β1对SCN5A基因变异所致心源性猝死调控的影响机制研究进展进行综述,以期为心源性猝死法医学研究和实践提供参考。     

HPLC-MS/MS法快速检测人体血液中的夹竹桃毒素

目的采用高效液相色谱-串联质谱法(HPLC-MS/MS)检测人体血液中夹竹桃苷、夹竹桃苷乙。方法采用乙腈沉淀蛋白法处理血液,HPLC-MS/MS法检测,采用MRM记录方式,保留时间和定性离子对定性,标准曲线法定量。结果夹竹桃苷、夹竹桃苷乙的检测限均在0.5ng/m L,线性范围在1ng/m L~1mg/m L,回收率为75.2%~95.7%。结论本方法操作简便,灵敏度高,可应用于中毒案件中人体血液中两种夹竹桃毒素(夹竹桃苷和夹竹桃苷乙)的快速检测。     

Measuring the Spatial and Temporal Patterns of Police Proactivity

Objectives

To measure where officers engage in proactive, self-initiated activities, how much time they spend being proactive, and whether their proactive activities coincide with crime patterns.

Methods

This study uses Andresen’s Spatial Point Pattern Test to compare the spatial similarity between police proactivity and crime, as well as regression modeling to explore the relationship between proactivity and crime and the time spent on proactivity and crime.

Results

In the jurisdiction examined, high levels of proactivity are noted. This proactive activity is more likely to occur in places where crime is most concentrated. Additionally, the number of proactive calls and the proactive time spent per crime-and-disorder call remain high and stable across spatial scales. For each crime call received at a street block, police initiated 0.7 proactive activities and spent approximately 28 min carrying out proactive works.

Conclusions

This study develops a way of measuring proactive activity by patrol officers using calls for service data. We find that not only do officers in this jurisdiction exhibit higher levels of proactivity to prevent crime (compared to reacting to crime), but they also do so in targeted, micro-place ways. Agencies may consider using similar techniques to gauge the levels of proactivity in their agencies if proactive activity is a goal.

     

以协调与融合为核心的环境法学方法论初探

环境法学者以后现代主义哲学思想为基础,提出了以“主客一体化”“生态化”为核心的整体主义环境法学方法论,但是这一环境法学方法论显然具有忽略人的因素的生态中心主义倾向,削弱和冲淡了其对实际环境问题的应对功能.由于整体主义环境法学方法论在很大程度上是从生态学原理直接推导而来的,以其为指导的环境法学与各传统部门法学的交流出现了障碍.我们有必要反思整体主义环境法学方法论的基础和逻辑,依据可持续发展理念,融汇自然科学和人文科学的思维方法,联系事实判断和价值判断,协调与融合环境、社会和经济因素,以此为基本出发点,建立以协调与融合为核心的环境法学方法论.     

Perceived risk of crime: A tale of two immigrant groups in Metro Detroit

A particular source of anxiety for many immigrants is personal safety. This study examines the levels and correlates of perceived risk of crime among two understudied immigrant groups, Arab and Chinese immigrants, who resided in an understudied geographic area, the Detroit metropolitan area. Results suggested several universal and immigrants-specific correlates that are significant predictors of Arab and/or Chinese immigrants' perceptions of crime, including self-defense ability, police effectiveness, neighborhood collective efficacy, language proficiency, expectation of U.S. crime condition prior to arrival, and perception of home society crime. Implications for future research are discussed.     

公安院校实验教学管理体制及教学内容研究

公安院校专业特殊,实验室建设起步较晚,传统的管理模式严重制约了公安高等教育的发展。公安院校实验室管理体制应是在主管校长的领导下,成立实验室专门管理机构,建立以校级中心实验室为龙头,系级综合实验室为主体,教研室研究应用型实验室为补充;以实验教学为主,融实验教学、科研、实际办案于一体的多功能综合性实验室管理体制。     

树立落实科学发展观推动高等教育健康发展

很高兴能有这样跟大家进行交流沟通的机会。国家教育行政学院举办的这两个培训项目很重要,高校领导干部进修班的同志都在学校从事重要的领导工作,高校中青年干部培训班的同志也是各高校中层干部队伍的骨干,随着学校事业的发展,将逐步承担起更为重要的领导工作职责。今天,我想利用这个机会,就当前高等教育面临的形势和发展的趋势与大家沟通一些信息,介绍有关情况,同时也和大家交流一些认识。一、我国高等教育所取得的主要成绩和经验1、坚持以发展为主题,推动我国高等教育事业不断跨上新的台阶。党的十五大以来,我国高等教育改革与发展实现了…     

试论政府在城镇化进程中的作用

城镇化在我国方兴未艾,政府在推进城镇化进程中如何发挥作用,关系到我国城镇化能否健康、可持续的发展．具体说,政府在推进城镇化发展中应在如下几个方面发挥重要作用：加强城市基础设施建设、消除阻碍城镇化进程的体制障碍、灵活运用市场力量等方面．     

对我国社区工作的本土化探讨

在现代化、国际化的社会条件下,人和人的关系出现一些新的特点;生活方式有很多的不同,呈现一种多元化趋势;社区机构在不断适应变化做出新的调整;家庭、邻里、同事等等关系也都在变化;这是一个动态的系统。为此,我们必须学习国外社区工作的经验,同时要根据我国的国情,建立起具有本土化特色的新型社区。